Speaker: Nathan Basisty, National Institute on Aging, NIH

Topic: Uncovering Aging Mechanisms Through a Proteomic Lens: From Protein Turnover to Surfaceomes

Date: Monday, November 14, 2022

Time: 6:15 pm Dinner, 7:15 pm Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)
This will be an in-person meeting. Attendees are required to show a vaccine card (either at the door or in advance using the web form) . If you have submitted your vaccine card before, your status is already recorded.

Dinner: Please RSVP to Andy Qi (andy.yue.qi@gmail.com) by Friday, November 11 if you will be attending the dinner.

Abstract: Mass spectrometry-based proteomics is a uniquely powerful tool to study basic mechanisms of aging. This talk will focus on how the Translational Geroproteomics Unit (NIA) leverages ‘geroproteomic’ approaches to develop biomarkers and therapeutic strategies against age related diseases stemming two major hallmarks of aging: loss of proteostasis and cellular senescence. Metabolic labeling studies have demonstrated that proteome turnover provides important insights into the biology of aging, however, measurement of whole animal turnover remains technically and computationally challenging. I will introduce a new freely available Skyline external tool, TurnoveR, that seamlessly integrates the computational pipeline analysis of protein turnover from metabolic labeling studies into the Skyline software environment. We hope this tool will facilitate the incorporation of protein turnover studies in the context of disease biology. Secondly, this talk will discuss how the Translational Geroproteomics Unit is leveraging secretome and surfaceome pipelines to develop strategies for quantifying and targeting pathogenic (senescent) cells that accumulate during aging to aid in the development of therapeutic against age-related diseases.