Speaker: Stephanie Cologna, University of Illinois Chicago

Topic: Mass Spectrometry Enabled Proteomics, Lipidomics and Imaging in Niemann-Pick Type C Disease

Date: Monday, October 17, 2022

Time: 6:15 pm Dinner, 7:15 pm Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)
This will be an in-person meeting. Attendees are required to show a vaccine card (either at the door or in advance using the web form) . If you have submitted your vaccine card before, your status is already recorded.

Dinner: Please RSVP to Andy Qi (andy.yue.qi@gmail.com) by Friday, October 14 if you will be attending the dinner.

Abstract: Mass spectrometry-based proteomics and lipidomics are powerful strategies to understand molecular mechanisms associated with human disease. Our laboratory studies Niemann-Pick Type C (NPC), a fatal, progressive neurodegenerative disorder that arises due to improper trafficking of cholesterol. As a result of the genetic defects in NPC, cholesterol storage is observed in late endosome/lysosome compartments. Subsequently, a series of downstream events occur including neuroinflammation, calcium imbalance, oxidative stress and progressive neuron loss with the disorder being ultimately fatal in the early adulthood years. In an effort to understand pathways associated with the downstream consequences of the genetic cause of NPC, we have employed mass
spectrometry imaging, quantitative proteomics and lipidomics in multiple models of NPC. In this seminar, I will share several examples of integrated ‘omics approach to reveal markers of NPC disease as well as seek insight into cell death in NPC using mass spectrometry.