NIST – NRC Post Doctoral Fellow (6/1/23)
NIH – Postdoctoral fellow (4/25/23)
Stanford University – Postdoctoral position in proteomics/signaling (3/25/23)
Georgetown University – Research Specialist in Proteomics (3/20/23)
Johns Hopkins University – Research Specialist (2/27/23)
Johns Hopkins University – Research Analyst (2/27/23)
NIST – Postdoctoral Fellow (2/24/23)
Univ. Maryland School of Pharmacy – Hydrogen-Deuterium Exchange Mass Spectrometry Specialist, Lead Specialist (2/15/23)
Mount Sinai Hospital – Assay Development and Validation Scientist (1/20/23)
FDA CFSAN – Researcher – Chemist (1/5/23)
FDA CFSAN – Support Scientist – Chemist (1/5/23)
FDA CFSAN – Post-Doctoral Fellow – Chemist (1/5/23)
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NIST – NRC Post Doctoral Fellow
Posted: June 1, 2023
Location: Gaithersburg, MD
Improving Peptide Identification By Making Use of All Levels of Liquid Chromatography-Tandem Mass Spectrometry Analysis
Location: Material Measurement Laboratory, Biomolecular Measurement Division
Please note: This Agency only participates in the February and August reviews.
Adviser: Meghan Catherine Burke Harris, meghan.burkeharris@nist.gov, 301-975-5631
Description
This project aims to leverage sample preparation methods, state-of-the-art instrumentation, and custom software algorithms to improve methods for peptide identification from raw mass spectral data. The use of orthogonal information such as multi-enzyme digestions, to verify the presence of a peptide using different proteases, and ion mobility adds layers of confidence to a given identification. Individuals with a background in mass spectrometry or software development are encouraged to apply.
Keywords:
mass spectrometry; liquid chromatography; mass spectral library; proteomics; peptide identification
Open to U.S. citizens
Base Stipend $74,950.00; Travel Allotment $3,000.00
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NIH – Postdoctoral fellow
Posted: April 25, 2023
Location: Bethesda, MD
NIH Intramural Center for Alzheimer’s Disease and Related Dementias (CARD, https://card.nih.gov/) is a newly established collaborative initiative of the National Institute on Aging (NIA) and National Institute of Neurological Disorders and Stroke (NINDS) that supports basic, translational, and clinical research on Alzheimer’s disease and related dementias. CARD has its own brand-new building in the heart of NIH main campus located in Bethesda, MD, allowing the access to NIH’s unparalleled resources and niche scientific initiatives. CARD’s central mission is to initiate, stimulate, accelerate, and support research that will lead to the development of improved treatments and preventions for these diseases. The Mass Spectrometry Expert (MSE) group, led by Dr. Andy Y. Qi, within CARD is to facilitate the ongoing and future multi-omics projects in the Alzheimer’s Disease related neurodegeneration research. The MSE group combines both wet and dry labs, with strong informatics team supporting large-scale integrated projects involved in genetics, transcriptome, proteome, and PTM-proteome. The MSE group is looking for an experienced, self-motivated postdoctoral researcher who will primarily work on integrated single-cell and spatial proteomics with spatial transcriptome (10X genomics) in human brain tissue to understand the pathology and pathogenesis of AD/ADRD. The MSE group currently has two high-resolution Orbitrap Eclipse, one triple quadrupole TSQ Altis Plus, and Agilent Bravo and KingFisher liquid handlers enabling automated sample preparation. We have cellenONE and laser dissection microscope (Leica) for single-cell and spatial proteomics. We have full-time data scientists for data homogenization and integration in large-scale multi-omics study. This position will include opportunities to access the resources for genetics, single-cell transcriptomics, high-resolution microscope, and publish high impact research in collaboration with NIH initiatives we support.
Responsibilities:
Generate datasets for mass spectrometry-based single-cell and spatial proteomics
study.
Prepare and process biospecimen and cell lines for proteomic analyses using automated
sample prep pipeline.
Analyze proteomic datasets using our in-house developed informatic pipeline.
Run and basic troubleshooting of LC-MS/MS instruments.
Conduct independent research relating to the functional genomics and proteomics of
neurodegenerative diseases.
Provide scientific and technical expertise to other group members and collaborators.
Prepare oral presentations and posters for internal and external conferences.
Work with top-notch intramural and extramural collaborators.
Conduct bioinformatics data analyses and statistical analyses; prepare data for abstracts
and manuscripts.
Write, edit, revise scientific publications in peer-reviewed journals.
Requirements:
Scientist level requires a PhD in neurobiology, biology, biochemistry related field with a
0–3-year post-degree experience.
Experience in single-cell (and/or bulk) proteomics, transcriptomics-related big data
analysis.
Experience in large dataset analysis algorithms on Linux and Google cloud and familiar
with R and python.
Understanding of basics of state-of-the-art methods for mass spectrometry-based and
microarray-based proteomics.
Experience in the development of computational methods for biological data analysis.
Preferred experience in LC-MS instrument, such as Thermo Scientific Orbitrap and TSQ
mass spectrometers.
Preferred experience in basic cell culture, microscopy, biochemistry, and molecular
biology.
Benefits:
Competitive compensation aligned with NIH Stipend guideline.
Comprehensive benefit package including health, vision, and dental plans.
Professional training and attending national/international scientific conferences.
How to apply:
Interested candidates please submit your CV and a short cover letter to Dr. Andy Qi andy.qi@nih.gov. The position is currently available and review of applications will begin immediately.
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Stanford University – Postdoctoral position in proteomics/signaling
Posted: March 25, 2023
Location: Stanford, CA
Summary of the position:
The Huttenhain Lab in the Department of Molecular & Cellular Physiology at Stanford is looking for postdoctoral fellows to study mechanisms of intracellular signal integration through G protein-coupled receptors (GPCRs) using cutting edge mass spectrometry-based proteomics, functional genomics, and molecular biology techniques. Applicants with expertise and interest in either (1) mass spectrometry-based proteomics, (2) molecular and cell biology including neuroscience, GPCRs, functional genomics or related techniques, or (3) computational biology are encouraged to apply.
Lab overview:
The communication between cells and their environment depends on decoding of extracellular cues into intracellular signaling cascades that are integrated through dynamic and context-specific networks driving the cellular responses. Given the complexity and dynamic state of signaling networks, the current understanding of their constituents and how they are spatiotemporally regulated in the cell as a result of a specific input is incomplete.
The Huttenhain lab, which will launch in April 2023 in the Molecular & Cellular Physiology Department (https://med.stanford.edu/mcp.html) at Stanford Medicine, studies mechanisms of intracellular signal integration through G protein-coupled receptors (GPCRs), the largest family of membrane receptors mediating most of our physiological responses to hormones, neurotransmitters and environmental stimulants. We employ an interdisciplinary approach to probe, model, and predict how signaling network dynamics translate extracellular cues sensed by GPCRs into specific phenotypic outputs. Developing quantitative proteomics approaches to capture the spatiotemporal organization of signaling networks and combining these with functional genomics and molecular biology techniques to study their impact on physiology, we aim to better understand GPCR signaling and to provide a solid foundation for the design and testing of novel therapeutics targeting GPCRs with higher specificity and efficacy.
Relevant publications:
Lobingier B, Hüttenhain R, Eichel K, Ting AY, Miller KB, von Zastrow M, Krogan NJ. (2017) An approach to spatiotemporally resolve protein interaction networks in living cells. Cell 169, 350-360. PMC5616215.
Polacco BJ, Lobingier BT, Blythe EE, Abreu N, Xu J, Li Q, Naing ZZC, Shoichet BK, Levitz J, Krogan NJ, Von Zastrow M, Hüttenhain R. (2022) Profiling the diversity of agonist-selective effects on the proximal proteome environment of G protein-coupled receptors. bioRxiv 2022.03.28.486115
Specific postdoctoral projects may include:
• Develop quantitative proteomics approaches to map spatiotemporally resolved interaction and signaling networks of GPCRs.
• Mapping signaling network dynamics of GPCRs in neuronal systems to uncover novel regulators and mechanisms of neuromodulation.
• Discover mechanisms how diverse ligands targeting GPCRs elicit diverse phenotypic responses.
• Develop computational approaches to model spatiotemporally resolved signaling networks.
Academic environment:
Stanford University provides a highly stimulating scientific environment that fosters collaborations and the exchange of ideas within and across disciplines. The Molecular & Cellular Physiology Department (https://med.stanford.edu/mcp.html) offers a world-class scientific environment and supports postdoctoral scholars throughout their postdoc with mentoring and training programs, seminar series, and annual retreats. The Huttenhain lab is committed to foster an inclusive, respectful, and collaborative environment with passion for science and mentorship. Trainees will have access to an outstanding infrastructure and resources including dedicated state-of-the-art mass spectrometers.
Required Qualifications:
• Ph.D. in life sciences, biomedical sciences, computer science, or a related discipline.
• Experience and publication record in neuroscience, proteomics, genetics, molecular biology, and/or computational biology.
• Ability to work well in a multidisciplinary, diverse, and collaborative research environment.
• A genuine passion for science, and creative thinking.
• Being self-motivated.
• Strong oral and written communication skills.
Required Application Materials:
• Cover letter that includes a description of relevant research experience and research interests.
• Curriculum vitae (including a complete publication list).
• Names and contact information for 2-3 references.
More information:
https://postdocs.stanford.edu/prospective/opportunities/open-postdoctoral-position-faculty-mentor-ruth-huttenhain
Ruth Huttenhain, Assistant Professor, ruthh@stanford.edu
Twitter: @rhuttenhain
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Georgetown University – Research Specialist in Proteomicst
Posted: March 20, 2023
Location: Washington, DC
Georgetown University School of Medicine is seeking a Research Specialist to perform proteomics services and apply cutting-edge proteomic techniques for basic and translational biomedical research. The candidate will work in a proteomics core lab, Georgetown University Medical Center. The candidate is expected to help maintain the state-of-the-art mass spectrometry instruments and play a key role in strengthening the method development for protein/peptide analysis, especially on PTM-omics (including glycoproteomics). The candidate will have plenty of opportunities to collaborate with scientists of very diverse background (including physicians) on campus, neighbor institutions (including NIH/FDA) and pharmaceutical companies in the Washington DC metropolitan area.
Key Responsibilities:
1. Operate, maintain, and troubleshoot advanced nanoUHPLC-MS/MS platforms
2. Develop analytical methods for the qualitative and quantitative proteomics/peptidomics
Requirements:
1. Master degree in Analytical Chemistry or related filed, PhD will be preferred.
2. Strong hands-on skills handling high resolution mass spectrometers from Thermo (e.g., Orbitrap Lumos) and Sciex (e.g., TripleTOF 5600/6600, Q-TRAP 6500)
3. Extensive hands-on experience in proteomic workflows (including sample prep., data acquisition, and
data analysis), especially for PTM-omics
4. Enriched experience with isotopic labeling and label-free proteomic quantification methods
5. Familiar with software and bioinformatic tools for proteomic data analysis
6. Good communication and English-writing skills
7. Highly motivated and self-driven with the flexibility to quickly adapt to different projects
8. Willing to supervise and train students and interns
To those who are interested, please send a cover letter and your CV to Dr. Junfeng Ma (jm3004@georgetown.edu). In the cover letter, please briefly describe your research experience, career plan, earliest starting date, and etc. The position is open immediately and we anticipate filling the position as soon as possible. Competitive salary and benefits can be provided to the candidate depends on experience level. Georgetown University offers an impressive benefits package (including an annual 403b retirement contribution and comprehensive individual/family healthcare plans).
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Johns Hopkins University – Research Specialist
Posted: February 27, 2023
Location: Baltimore, MD
The Pathology Department is seeking a Research Specialist who is proficient research and/or clinical laboratory specialist with a firm understanding of techniques and a solid foundation in the underlying science, gained from some professional experience.
Under minimal supervision, performs clinical and/or research laboratory experiments by following established procedures and protocols. Participates in the design of experiments and analyzes data. Works independently and manages daily research projects. The research specialist will assist the principal investigator in the development and coordination of projects, experimentation, data collection/maintenance, and organization of the laboratory. Runs lab tests and completes measurements as assigned. Identifies and resolves problems and uses analytical and decision making skills to implement assigned projects.
Specific Duties & Responsibilities
Responsible for routine operational activities such as: ordering supplies and materials, reviewing inventory, maintaining up to date records of tests, etc. Preventative maintenance of equipment and laboratory operation procedures. Perform miscellaneous related duties as assigned.
Interfaces with outside contacts, including presenting at meetings, leading multi-institution work groups, representing Johns Hopkins among research colleagues.
Create and maintain cell cultures and maintain tissue culture or animal experiments and perform analysis of cells and animal models.
Assist the principal investigator to coordinate the responsibilities for different projects and manage the laboratory operation.
Train students, staff members, and postdoctoral fellows with established SOPs for sample preparation and instrument operation.
Exchange routine information in an appropriate manner. Regular interaction with students, vendors, post-doctoral fellows, and faculty members.
Maintain database and organize specimens and resources.
Report experimental procedures, results, and problems to PI through planned communication verbal and written/reports and logs.
Record outcomes/results of all experiments by writing.
Follows established procedures and protocols, utilize appropriate technique to develop, perform and analyze laboratory tests and/or experiments which may include making protocol modification within the parameters set by investigator.
Performs clinical and/or research lab tests and experiments. Plans and runs set of experiments after discussion with investigator.
Equipment, Machine, or Tool Requirements
Computer and Laboratory equipment maintaining and operation lab such as: HPLC, mass spectrometers, cell culture systems, spectrophotometer, centrifuges, freezers, vacuum, etc.
Special Knowledge, Skills, & Abilities
Have strong communication skills. Uses various software applications, such as spreadsheets, relational databases, statistical packages, and graphics packages to assemble, manipulate and/or format data and/or test reports.
Knowledge of good lab practices required. Individual must be able to work independently, under minimal supervision with strong decision-making skills and good judgment.
Physical Requirements
While performing the duties of this job, the employee may remain in a stationary position (sitting or standing) up to 70% of the time. Occasionally required to traverse throughout the laboratory or to retrieve equipment, supplies, or specimens from other locations on campus. The employee is required to operate computer keyboard, laboratory instruments, and small laboratory tools such as pipettes, cutting instruments, glass tubes, dishes, and/or slides. Constantly repositions self to perform duties at laboratory workstations, gathering specimens, and loading equipment.
Prolonged vision requirements including viewing computer screen, paper reports/documents, charts and results. Visual acuity is required to distinguish fine gradation of color or structure and closely examine specimens (including via a microscope).
Laboratory environment – Exposure to toxins and infectious agents exist, but potential for personal injury or harm is minimized if established safety and health precautions are followed. Must refer to and are expected to comply with procedure manuals, follow proper laboratory protocols and safety policy/procedures, and be familiar with material data safety sheets in assigned work areas. Able to read and understand all Health, Safety and Environment (HSE) guidelines applicable to assigned work area. Working in laboratory where there may be discomforts due to odors, noise, temperature fluctuations, and working around lab equipment. Research areas may include animal, human, human products, DNA, radiation protocols, and other bio-hazardous materials. Use of personal protective equipment may be advised or required.
May transport equipment and supplies usually less than 40 pounds from one area to another (in the laboratory or on campus (specify)). May be required to lift and/or move up to 50 pounds with proper training, or precautions/lifting aides (example: supply boxes or Formalin cubes). In some areas workspace is limited.
Staff may be required to complete annual competency review, and must ensure compliance with Johns Hopkins Policy, Laboratory Policy & Procedure, Health, Safety & Environment regulations, and all applicable privacy & confidentiality laws/practices. Rotating on-call, weekend, or pager duties are required. Many department laboratories operate 24/7 with schedules on day, evening, or night shift. Rotating schedules which may include weekend work and holiday assignment. (Overtime possible when authorized/needed to meet business and patient needs). In the event of unexpected university closings including inclement weather or declared emergency, the employee in this position is required to report to work and/or remain at work.
Minimum Qualifications
Bachelor’s Degree in Biology, Chemistry or related field.
One year laboratory experience performing relevant techniques.
Master’s degree, with related graduate research, may substitute for experience to the extent permitted by the JHU equivalency formula.
Preferred Qualifications
Course work in related areas like biomedical science, genetics, immunology.
Masters Degree preferred.
Classified Title: Research Specialist
Role/Level/Range: ACRP/03/MA
Starting Salary Range: $16.61-$22.83-$29.04 HRLY (Commensurate with experience)
Employee group: Full Time
Schedule: M-F 9:00am-5:00pm
Exempt Status: Non-Exempt
Location: School of Medicine Campus
Department name: SOM Pat Clinical Chemistry
Personnel area: School of Medicine
Apply online
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Johns Hopkins University – Research Analyst
Posted: February 27, 2023
Location: Baltimore, MD
The Pathology Department is seeking a Research Analyst who will provide day-to-day leadership and coordination for the projects involved in the Mass Spectrometry Core Facility.
With a high level of independence and minimal supervision, the incumbent will provide supervision and directions to technical staff on various aspects of research activities and utilize advanced scientific knowledge and experience. Examples of responsibilities include coordinating efforts on planning and implementing technology development for sample preparation, mass spectrometry analysis, data processing of mass spectrometry data, and the applications of the technologies to the clinical proteomics glycoproteomic. The Research Analyst will report to Principal Investigators (PIs) and study investigators to prepare manuscripts and funding applications.
Specific Duties & Responsibilities
Oversee, coordinate, and be involved with implementation of all phases of proteogenomic for biological and clinical investigations and validation.
Provide technical assistance to research studies and training.
Participate in meetings and make recommendations on operational issues.
Facilitate communication internally among members of the team, including maintaining action items, timelines, and work plans.
Make recommendations on budget and expenditures.
Preparation of technical reports, manuscripts, abstracts, presentations, and funding applications.
Maintain study record and data collection procedures.
Attend local and national meetings and conferences.
Serve as a resource for investigators and collaborators.
Write report manuscripts for NCI funded projects, independently.
Complete other duties as assigned by PI.
Special Knowledge, Skills, & Abilities
Develop, design and manage substantial research projects, coordinates own objectives and those of laboratory team members.
May oversee data collection, analysis, and verification based on specialized skill and knowledge.
Use advanced knowledge base to formulate research method, for example, construct new immunoassay and/or apply methods to automated instruments.
Co-author/author publications. Contribute original thoughts, hypotheses, and analysis to write reports, abstracts and manuscripts.
Speak at or attend conference representing issues and Hopkins research.
Write grant proposals utilizing the application of specialized knowledge with discretion and judgment.
Independently develop protocol and criteria.
Make decisions regarding research projects that may require assessment, revision of objectives, or altering scientific direction; considers resources and lab priorities when making decisions.
Physical Requirements
While performing the duties of this job, the employee is regularly required to sit, talk, see and hear. May sit or stand for prolonged periods and occasionally required to walk. The employee is frequently required to use hands to finger, touch, feel, and type. May reach with hands and arms; stoop, kneel, or crouch. Prolonged vision requirements including viewing computer screen, paper reports/documents, charts and results.
Visual acuity is required to distinguish fine gradation of color or structure and closely examine specimens microscopically. Must possess manual dexterity sufficient to work with small instruments and delicate equipment.
Clinical laboratory environment – Exposure to toxins and infectious agents exist, but potential for personal injury or harm is minimized if established safety and health precautions are followed. Working in laboratory where there may be discomforts due to odors, noise, temperature fluctuations, and working around lab equipment.
May transport equipment and supplies usually less than 40 pounds from one area to another. May be required to lift and/or move up to 50 pounds with proper training, or precautions/lifting aides.
In some areas workspace is confined; therefore, mobility may be difficult.
Staff may be required to complete annual competency review, and must ensure compliance with Hospital Policy, Laboratory Policy & Procedure, Health, Safety & Environment regulations, and all applicable privacy & confidentiality laws/practices.
Must be detail oriented, organized, and accurate.
Many department laboratories operate 24/7 with schedules on day, evening, or night shift. Rotating schedules which may include weekend work and holiday assignment. Overtime possible when authorized/needed to meet business and patient needs.
The above statements are intended to describe the general nature and level of work being performed. They are not to be construed as an exhaustive list of skills, efforts, duties, responsibilities, knowledge, or abilities required of the position.
Minimum Qualifications
Master’s Degree in a related science.
Six years related experience, with proven technical knowledge and laboratory experience.
Preferred Qualifications
Experience with managing staff.
Experience providing oversight/technical assistance for research operations, including mass spectrometry, HPLC, assay development, and previous experience coordinating, conducting, and managing studies.
Classified Title: Research Analyst
Role/Level/Range: ACRP/04/MF
Starting Salary Range: $72,940-$100,380-$127,820 Annually (Commensurate with experience)
Employee group: Full Time
Schedule: M-F, 9:00am-5:30pm
Exempt Status: Exempt
Location: School of Medicine Campus
Department name: SOM Pat Clinical Chemistry
Personnel area: School of Medicine
Apply online
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NIST – Postdoctoral Fellow
Posted: February 24, 2023
Location: Gaithersburg, MD
In contribution to the NIST Circular Economy Program (https://www.nist.gov/circular-economy), the NIST Mass Spectrometry Data Center is working on a comprehensive approach to the chemical analysis of plastics-related compounds (PRC) using mass spectrometry. Due to the versatility of plastics, many manufactured products and environmental pollutants are associated with PRC. The postdoctoral candidate will be working to extend existing NIST mass spectral libraries (https://www.nist.gov/srd/nist-standard-reference-database-1a) to include all plastics-related compounds (monomers, additives, and processing aids of the plastics industry, etc.) and developing experimental methods and software tools for the identification and quantification of PRC in a variety of samples including polymer mixtures, extractables and leachables (E&L) from plastics, human biofluids, drinking water, and nanoplastics.
These analytical methods will be oriented to solve urgent problems related to the chemistry of plastics in a circular economy, e.g., sorting, recycling, repurposing, etc. Also, part of the work will be dedicated to build reliable risk assessment tools. In collaboration with the FDA and the EPA, E&L from plastics used in biomedical applications (infusion bags, drug containers, orthopedic casts, etc.) will be studied, for example, the presence of PRC in human biofluids (blood, urine, breast milk, etc.). The analytical methods, computational tools, and spectral information will be shared and disseminated through the EPA CompTox Chemical Dashboard.
Candidates should email Yamil Simon at yamil.simon@nist.gov
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Univ. Maryland School of Pharmacy – Hydrogen-Deuterium Exchange Mass Spectrometry Specialist, Lead Specialist
Posted: February 15, 2023
Location: Baltimore, MD
The University of Maryland, Baltimore (UMB) School of Pharmacy’s Department of Pharmaceutical Science is currently seeking creative, motivated, and organized candidates to fill the Hydrogen-Deuterium Exchange Mass Spectrometry HDX-MS Specialist (Lab Research Specialist) within the Deredge laboratory.
For more information on the Deredge laboratory, visit: https://deredgelab.com/
Established in 1841, the University of Maryland School of Pharmacy is the fourth oldest school of pharmacy in the United States. As a leader in pharmacy education, scientific discovery, patient care, and community engagement, the School conducts cutting edge research and engages in a wide variety of professional practice activities to improve the health and well-being of citizens in the state of Maryland and beyond.The Department of Pharmaceutical Sciences houses the School of Pharmacy’s Mass Spectrometry Center which is an Organized Research Center that hosts 20 state-of-the-art mass spectrometers and has expertise in metabolomics, lipidomics, proteomics, drug analysis, protein structure, and mass spectrometry imaging with an emphasis on collaborative research.
For more information visit: http://www.pharmacy.umaryland.edu/centers/massspec/
The position will primarily involve the use of HDX-MS to characterize the structure and dynamics of a variety of protein systems, both from therapeutic and non-therapeutic development perspective, obtained from various external investigators, industry partners and clients. The position is funded by grant or contract and will offer extensive opportunity for interactions with investigators from a leading pharmaceutical company. In particular, the successful applicant will be responsible for liaising with the industry partner to design, develop and execute various workflows focused on HDX-MS.
ESSENTIAL FUNCTIONS:
• Identify, advise, or assist investigators with sample preparation strategies.
• Design and develop appropriate reaction conditions and HDX-MS workflow to characterize the structure and dynamics of various protein systems.
• Implement the developed HDX-MS reaction and workflow.
• Perform, analyze, and interpret HDX-MS acquisitions. Prepare reports and all appropriate documentation including administrative and business-related documents.
• Abide by all requirements, regulations, laws as well as agreements pertaining to the work, including non-disclosure agreements if applicable.
• Participate in development and implementation of training materials used to train staff, students, or fellows in HDX-MS and other advanced techniques by mass spectrometry used in the Deredge laboratory and/or the Mass Spectrometry center.
• Participate in activities pertaining to the Deredge laboratory and MS Center operations including laboratory and HDX-MS platform maintenance.
• May perform independent research in technological developments in HDX-MS, intact Mass Spectrometry and Native Mass Spectrometry.
• Perform other related duties as assigned.
Qualifications
MINIMUM QUALIFICATIONS:
EDUCATION: Bachelor’s degree in biology, chemistry, biochemistry, or field of study related to the research of the laboratory. Master’s degree or PhD is preferred.
EXPERIENCE: Three (3) years of experience including two (2) years in mass spectrometry. Experience in research success and working both independently and in a team environment preferred. Experience with Waters liquid chromatography and Synapt instrumentation preferred. Post-doc experience preferred.
OTHER: May require training related to occupational safety and health, environmental compliance, shipping of hazardous materials and/or ionizing radiation. May include working in biohazardous/select agents and/or in Biosafety Level-2 Laboratories (BSL-2). May consider a combination of directly related experience and education.
REQUIRED KNOWLEDGE/SKILLS/ABILITIES:
• Knowledge of position requirements.
• Knowledge of all applicable requirements, regulations, and laws.
• Skill in effective use of applicable technology/systems.
• Strong ability to effectively communicate both verbal and written thoughts, ideas, and facts.
• Ability to work cooperatively with others and independently.
• Ability to demonstrate, understand, apply, and adhere to the UMB Core Values of Respect and Integrity, Well-being and Sustainability, Equity and Justice, and Innovation and Discovery.
Additional information and application portal here: https://umb.taleo.net/careersection/umb_external_staff/jobdetail.ftl?job=220000Y1&lang=en
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Mount Sinai Hospital – Assay Development and Validation Scientist
Posted: January 20, 2023
Location: New York, NY
The Clinical Chemistry and Immunology Service at the Mount Sinai Hospital Department of Pathology is recruiting an Assay Development and Validation Scientist in clinical mass spectrometry. The successful candidate will be responsible for test development, validation, and implementation of clinical tests utilizing state-of-the-art liquid chromatography-mass spectrometry platforms with focus in the areas of clinical toxicology, therapeutic drug monitoring, high-resolution mass spectrometry, and targeted proteomics.
The successful applicant has a Ph.D. or Master’s Degree in analytical chemistry, biochemistry, toxicology, clinical chemistry, or related fields. Candidates must have previous experience with liquid chromatography, high resolution mass spectrometry (e.g. TOF and orbitrap), and triple quadrupole mass spectrometers with a minimum 3 years of experience developing assays in a clinical laboratory environment or diagnostics industry. In addition, the candidate will possess excellent troubleshooting skills as well as excellent written and spoken communication skills. Candidates with experience in immunoassay platforms and previous experience in leadership are preferred.
Duties and Responsibilities
• Daily preparation of biological or environmental samples for analysis by LC-MS/MS
• Assist with operation and maintenance of instruments
• Daily evaluation of instrument performance and QA/QC, with ability to troubleshoot if results do not satisfy pass/fail criteria
• Method development, verification, and establishing assay suitability criteria
• Perform chemical identification analysis, including MS/MS, running of standards, and creating confirmed metabolite databases
• Receipt, cataloging, and inventory of environmental and biological samples
• Contribute to preparation of grant applications, reports, and manuscripts
• Assisting with oversight of research projects and meeting project deadlines
• Assist with ordering of laboratory supplies and consumables
Interested candidates, please send correspondence by email including curriculum vitae, a statement describing experience and interest to:
Folagbayi Arowolo, PhD
Assistant Director of Clinical Chemistry
Department of Pathology, Molecular & Cell-Based Medicine
Mount Sinai Hospital
1425 Madison Avenue, Icahn Building room 8-52, New York, NY 10029
212-659-8130
Email: folagbayi.arowolo@mountsinai.org
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FDA CFSAN – Researcher – Chemist
Posted: January 5, 2023
Location: College Park, MD
The U.S. Food and Drug Administration’s (FDA) Center for Food Safety and Applied Nutrition (CFSAN) in College Park, Maryland seeks to hire scientists to participate in our food safety research program. The Office of Regulatory Science (ORS) within CFSAN conducts laboratory investigations in a variety of research areas which include, but are not limited to, food additives, allergens, protein toxins, bacterial identification, plant incorporated protectants, nanomaterials, free radical formation, seafood toxins, species identification, economic adulteration, non-targeted analysis, and industrial contaminants in CFSAN-regulated food, packaging, and cosmetic products. Candidates with expertise in any of the following areas are encouraged to apply: mass spectrometry, non-targeted analysis using HR-MS, spectroscopy, (including IR and Raman), total organic fluorine, antibody-based analyses, and elemental analysis.
Candidates should have a Ph.D. in chemistry or a related field. Job responsibilities can include, but are not limited to, (1) developing, adapting, and validating quantitative analytical methods for the determination of a variety of compounds in foods, packaging, and cosmetics, (2) operating and maintaining highly complex and specialized scientific instrumentation, (3) writing reports, scientific papers, and scientific publications, and (4) representing the organization on scientific committees and participation at scientific conferences and meetings.
U.S. citizenship is required, and the start date is negotiable. Starting salary is dependent upon experience and ranges from $94,199-$112,015 (plus benefits). If interested, please email your CV to ORS-DAC-inquiry@fda.hhs.gov.
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FDA CFSAN – Support Scientist – Chemist
Posted: January 5, 2023
Location: College Park, MD
The U.S. Food and Drug Administration’s (FDA) Center for Food Safety and Applied Nutrition (CFSAN) in College Park, Maryland seeks to hire support scientists to participate in our food safety research program. The Office of Regulatory Science (ORS) within CFSAN conducts laboratory investigations in a variety of research areas which include, but are not limited to, food additives, allergens, protein toxins, bacterial identification, plant incorporated protectants, nanomaterials, free radical formation, seafood toxins, species identification, economic adulteration, non-targeted analysis, and industrial contaminants in CFSAN-regulated food, packaging and cosmetic products. Candidates with a background in method validation and a wide-range of sample preparation techniques including, but not limited to, solid phase extraction (SPE), liquid-liquid extraction, QuEChERS, dissolution, proteomics, etc. are encouraged to apply. Expertise in any of the following areas is also desirable: mass spectrometry, spectroscopy (IR and Raman), total organic fluorine, antibody-based analyses, and elemental analysis.
Candidates should have a bachelor’s or master’s degree in chemistry or a related field. Job responsibilities can include, but are not limited to, (1) providing support to principal investigators by conducting and/or assisting in scientific investigations or testing activities for the determination of a variety of compounds if foods, packaging, and cosmetics, (2) assisting in the operation and maintenance of highly complex and specialized scientific instrumentation, (3) contributing to the writing of reports, scientific papers, and scientific publications, (4) participation at scientific conferences and meetings, and (5) conducting tasks such as maintaining laboratory safety standards and cleanliness, QA activities, ordering of laboratory supplies, and/or other ancillary duties.
U.S. citizenship is required, and the start date is negotiable. Starting salary is dependent on experience and ranges from $78,592-$89,069 (plus benefits). If interested, please email your CV to ORS-DAC-inquiry@fda.hhs.gov.
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FDA CFSAN – Post-Doctoral Fellow – Chemist
Posted: January 5, 2023
Location: College Park, MD
The U.S. Food and Drug Administration’s (FDA) Center for Food Safety and Applied Nutrition (CFSAN) in College Park, Maryland seeks to hire post-doctoral fellows to participate in our food safety research program. The Office of Regulatory Science (ORS) within CFSAN conducts laboratory investigations in a variety of research areas which include, but are not limited to, food additives, allergens, protein toxins, bacterial identification, plant incorporated protectants, nanomaterials, free radical formation, seafood toxins, species identification, economic adulteration, non-targeted analysis, and industrial contaminants in CFSAN-regulated food, packaging and cosmetic products. Candidates with a background in any of the following areas are encouraged to apply: mass spectrometry, non-targeted analysis using HR-MS, spectroscopy (IR, Raman, and/or NMR), total organic fluorine, antibody-based analyses, and elemental analysis.
Candidates should have a Ph.D. in chemistry or a related field. Job responsibilities can include, but are not limited to, (1) adapting, developing, and/or validating quantitative analytical methods for the determination of a variety of compounds in foods, packaging, and cosmetics, (2) operating and maintaining highly complex and specialized scientific instrumentation, (3) writing reports, scientific papers, and scientific publications, and (4) participation at scientific conferences and meetings.
The start date is negotiable and the salary range is $68-95k. If interested, please email your CV to ORS-DAC-inquiry@fda.hhs.gov.
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