Available Positions

FDA CFSAN – Postdoctoral Research Fellow (3/21/24)

FDA – Postdoctoral Research Fellow (1/15/24)

National Gallery of Art – Physical Scientist (Chromatographer) (12/15/23)

AstraZeneca – Postdoctoral Fellow – Biomarker Discovery Proteomics (10/24/23)

Frederick National Laboratory – Associate Scientist – Mass Spectrometry Proteomics (9/12/23)


FDA CFSAN – Postdoctoral Research Fellow

Posted: March 21, 2024
Location: College Park, MD

The Office of Regulatory Science in the U.S. Food and Drug Administration’s Center for Food Safety and Applied Nutrition (US FDA/CFSAN) is seeking a post-doctoral fellow to conduct research in our food safety research program. This is a one-year position with possibility of renewal. The primary research goal for this position is to utilize established methods to quantify PFAS in non-stick cookware coatings and food processing equipment in collaboration with the Office of Food Additive Safety for the determination of potential exposure to PFAS from food contact articles (FCAs).
A Ph.D. in Analytical Chemistry, Biochemistry, or related fields is required and must have been obtained within the past 5 years. Applicants to this position should have a strong background and interest in learning and gaining experience with targeted liquid chromatography/tandem mass spectrometry (LC-MS/MS) techniques. Knowledge or experience with Shimadzu Nexera UPLC and Sciex QTRAP 6500+ systems, food science, and food analysis method development is highly desirable. The ability to effectively communicate both verbally and in writing is essential.

The primary responsibilities of this position will include planning and conducting laboratory experiments, analyzing, and managing data, and preparing manuscripts and presenting research findings at scientific conferences.

U.S. citizenship, permanent resident status, or a valid J1 Visa is required. Applicants must have resided in the United States for at least 36 of the previous 60 months to be eligible. The position is located at FDA’s Center for Food Safety and Applied Nutrition in College Park, MD. Applicants should submit a curriculum vitae, names of references, and a statement describing how their experience, skills and interests are suited to this position to katherine.l.fiedler@fda.hhs.gov.

FDA – Postdoctoral Research Fellow

Posted: January 15, 2024
Location: Silver Spring, MD

An ORISE postdoc research fellow position is immediately available at Division of Product Quality Research, Office of testing Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration in Silver Spring, MD. The candidate will work with staff scientists on projects characterizing therapeutic peptides and proteins using high resolution mass spectrometry. Hands-on experience with Orbitrap and/or Q-TOF mass spectrometer is preferred, and research expertise on hydrogen-deuterium exchanging mass spectrometry will be a plus. The qualified fellow will receive competing stipend (salary) and benefits. Please submit a resume to Mack Shih (Mack.shih@fda.hhs.gov) and/or Jinhui Zhang (Jinhui.zhang@fda.hhs.gov). Feel free to contact us for any questions related to this opportunity and we look forward to discussing with you.

National Gallery of Art – Physical Scientist (Chromatographer)

Posted: December 15, 2023
Location: Washington, DC

Open & Closing Date: 12/15/2023 to 12/29/2023
Pay scale & grade: GS 12
Salary: $94,199 to $122,459 per year

This position is in the Scientific Research (CL-SR) department of the National Gallery of Art. The primary purpose of the Conservation Scientist position is to support the mission of the CL-SR department by applying scientific expertise to analyze and investigate art-related materials, contribute to the development of conservation strategies, and push the boundaries of scientific knowledge in the context of art preservation. As the Physical Scientist, you will:

• Evaluate requests for analysis from conservators, conservation scientists and curators and recommend appropriate chromatographic/separation techniques and may also include microscopy, imaging, or spectroscopic methods.
• Act as lead scientist to undertake analyses, using a variety of skills in chromatographic methods, and as required, microscopy, spectroscopy, or other types of analysis.
• Advise staff, contract employees, fellows, and interns in the best practices of use of conservation science equipment and instructs and assist them in the interpretation of resulting data.
• Conduct research related to the understanding and preservation of tangible cultural heritage with a focus on the National Gallery’s collections and on conservation and treatment methods.
• Initiate and collaborate on research projects to develop and improve analytical methods for the identification of artists’ materials and to improve the quality of materials and procedures for treating and preserving works of art.
• Author technical reports and publishable papers for scientific and humanities audiences, prepare and deliver public lectures and demonstrations.

To apply, please visit:
https://www.usajobs.gov/job/765834700 (Job Announcement NGA-23-037-DE) for United States citizens, Nationals, or those who owe allegiance to the U.S.
https://www.usajobs.gov/job/765836600 (Job Announcement NGA-23-037-MP) for United States citizens, who are individuals with disabilities, current or former federal employees, career transition (CTAP, ICTAP, RPL), and others as defined in federal hiring regulations.

This is a Federal position; candidates must be U.S. citizens, Nationals, or those who owe allegiance to the U.S. Applications must be submitted on-line through USAJOBS.gov and will be accepted December 15, 2023 to December 29, 2023.

AstraZeneca – Postdoctoral Fellow – Biomarker Discovery Proteomics

Posted: October 24, 2023
Location: Gaithursburg, MD

Do you have expertise in, and passion for mass spectrometry-based proteomics and biomarker discovery in cardiovascular diseases? Would you like to apply your expertise to impact the biomarker discovery in a company that follows the science and turns ideas into life changing medicines? Then join the Dynamic Omics team at AstraZeneca and unlock the power of what science can do.

About our Postdoc Programme
Bring your expertise, apply your knowledge, follow the science, and make a difference. AstraZeneca’s Postdoc Programme is for self-motivated individuals looking to deliver exciting projects in an encouraging, engaging, and innovative environment. You’ll work with multidisciplinary scientific teams from a diverse set of backgrounds and a world-class academic mentor specifically aligned to your project. Our postdocs are respected as specialists, encouraged to speak up, and supported to share their research at conferences, publish papers, achieve their goals.
Make a more meaningful impact in your career, with greater ownership and accountability to make a contribution whilst making a difference to the lives of our patients!
This is a 3-year programme.

About the Opportunity
The purpose of this position is to provide early-career researchers with an opportunity to further develop their expertise and skills in the field of proteomics, specifically in the context of cardiovascular diseases. Postdocs play a crucial role in advancing scientific knowledge and driving innovation in the pharmaceutical industries.
The successful postdoc will join AstraZeneca’s Dynamic Omics team, a part of the Centre for Genomics Research (CGR) and Discovery Sciences within AstraZeneca. Discovery Sciences provides high quality hits, leads and drug candidates to AstraZeneca project teams. Our use of advanced omics capabilities continues to drive target validation and identification efforts as we continue to evolve the way that we create new leads for the next generation of medicines. As a member of the Dynamic Omics team under Discovery Sciences, the postdoc will be actively involved in preclinical and clinical studies using high-throughput proteomics workflows and advanced bioinformatics.

Project Focus
This project will conduct pioneering research in heart failure diseases by applying pioneering mass spectrometry-based proteomics tools. Our postdoc will collaborate with experienced AstraZeneca’s interdisciplinary scientists in different areas including and mass spectrometry, bioinformatics, molecular biology, cardiology and animal physiology, and an extraordinary academic mentor specifically aligned to the project. The postdoc will have opportunities to develop career aspirations in an extremely supportive and collaborative environment and make a significant scientific contribution to the field of cardiovascular proteomics research.

Supported by Sophia Chung, Senior Scientist, Clinical Omics at AstraZeneca, you’ll also receive academic mentorship and guidance from David A Kass, Johns Hopkins University School of Medicine, Cardiology. The position is located at our R&D site in Gaithersburg, United States.

What You’ll Do
We are looking for scientists with the essential skills and qualifications, track records of academic achievements, easy-to-communicate, approachable personnel, and great collaborators.
This role will primarily lead proteomics projects within Dynamic Omics, CGR, and will be supported by CVRM (Cardiovascular, Renal and Metabolism). The successful postdoc will have the opportunity to work and grow in a fast-paced environment.

Key Duties & Responsibilities:
Operating, maintaining, and troubleshooting liquid chromatography-mass spectrometry instrumentation (LC-MS/MS) (e.g. Astral, Ascend, timsTOF)
Developing and applying all aspects of bottom-up proteomics and PTM proteomics workflows including experimental design, sample preparation, data analysis, and summarizing data for presentations and publications with accountability for accuracy
Leading the development and optimization of PTM enrichment methods
Optimizing and applying new technological and data analysis platforms
Designing and performing cell- or animal-based assays in lab and process various types of samples (e.g. cells, tissues or human samples)
Leading manuscript publication, demonstrating creative and independent scientific thinking to solve complex technical and scientific problems.

Qualifications, Skills & Experience
Essential Requirements
PhD, or equivalent in biochemistry, analytical chemistry, chemistry, medicine, pharmacology or biology/chemistry-related fields
Extensive experience in mass spectrometry-based proteomics applications
Strong theoretical understanding of analytical chemistry and practical knowledge of instrument interfaces
Experience with a variety of omics data analysis and bioinformatic tools, including commercial software and programming languages
Hands-on experience in basic biochemistry or biology assays/experiments.

Desirable Requirements
Hands-on experience on Orbitrap or timsTOF platforms
Experience in PTM analyses, such as sample processing, MS acquisition, and data analysis for PTM site localization
Expertise in DIA workflow or multi-omics integrated analysis
Experience in molecular biology experiments (e.g. IP, co-IP, tissue cultures, gene editing, KO/OE, PCR, imaging), and familiarity with software tools to design the experiments
Strong background in heart failure or related diseases

Reasons to Apply
This is a fantastic opportunity to collaborate with experts in proteomics, genomics (CGR), and cardiovascular disease area, grow as a scientist, develop your career in a broad scientific community, and publish high-impact publications. You will lead projects and have access to the latest version of instruments, precious and valuable cohorts and develop pioneering techniques.

We will empower you to take appropriate risks and lead the project whilst providing you with the support you need from the multi omics groups, CVRM and the academic supervisor; a leading clinician-researcher in the heart failure field, with a distinguished career spanning over two decades.

As a key member of a research group and taking a leading role on a Postdoctoral project, we expect regular attendance – a minimum of 3 days per week on the AstraZeneca campus. For laboratory-based scientists, this may be higher.
Given the unique positioning of our Postdoctoral researchers, you may have an additional opportunity to spend some time with an external academic mentor. In this instance, you may be required to spend some of your time working alongside them at their facility as driven by the research project. Your flexibility to meet the needs of the research and the scope of the project is required, and we also look to support you with flexibility in accordance with our standard work policies.

This advert will be running from Monday, 23rd October 2023 and, we welcome your application as soon as possible, but ahead of the scheduled closing date of Sunday, 14th January 2024. In the event, that we identify suitable applicants ahead of the scheduled closing date, we reserve the right to withdraw the vacancy earlier than published.

Find Out More
AZ’s Postdoc Programme: https://careers.astrazeneca.com/postdocs-astrazeneca
Life at AstraZeneca: https://careers.astrazeneca.com/life-at-astrazeneca
This is what we’re made of: https://www.youtube.com/watch?v=pmFx_jr2eFo&t=2s

Apply Online

Frederick National Laboratory – Associate Scientist – Mass Spectrometry Proteomics

Posted: September 12, 2023
Location: Frederick, MD

The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.

Work independently and collaboratively with scientists to perform liquid chromatography-mass spectrometry (LC-MS)-based proteomics experiments, including: protein extraction/digestion, immunoprecipitation, solid-phase extraction (SPE), buffer preparation, enrichment, etc. following established SOPs
Help operate and maintain state-of-the-art LC-MS instrumentation (SCIEX 7500 and Thermo TSQ Altis) and ensure high quality data generation for targeted proteomics
Perform comprehensive data analysis using a variety of methods and software, such as Skyline, Excel, R, Python, etc.
Establish (design, test, and write) new or modify/optimize existing detailed technical SOPs
Document experimental results in a reproducible manner
Analyze, interpret, and effectively present data to team members and collaborators
Comply with all safety procedures and policies

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
Possession of a Bachelor’s degree in biochemistry, analytical chemistry or other related discipline from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Additional qualifying experience may be substituted for the required education. Foreign degrees must be evaluated for U.S. equivalency
In addition to educational requirement, a minimum of eight (8) years of related laboratory experience is required
Both theoretical and hands-on experience in MS-based targeted (MRM and/or PRM) proteomics, including but not limited to: separation chemistry, sample preparation, LC-MS operation and troubleshooting, and data analysis
Detail-oriented, highly-collaborative, self-motivated, and team-oriented
Excellent verbal communication skills
Ability to obtain and maintain a security clearance

Candidates with these desired skills will be given preferential consideration:
Master’s degree in biochemistry, analytical chemistry or other related discipline from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Additional qualifying experience may be substituted for the required education. Foreign degrees must be evaluated for U.S. equivalency
6 years of related post graduate MS-based proteomic experience
Experience operating a SCIEX 7500 and/or Thermo TSQ Altis
Experience operating a Waters M-Class UPLC, and/or Thermo UltiMate nanoLC (i.e., microflow or nanoflow LC, respectively)
Experience with Skyline software
Experience with Covaris ultrasonicators and/or liquid handlers
Experience performing global proteomics experiments
Familiarity with CLIA requirements

Apply online at https://leidosbiomed.csod.com/ux/ats/careersite/4/home/requisition/3693?c=leidosbiomed