NIH National Institute of Diabetes and Digestive and Kidney Diseases – Mass Spectrometrist (12/17/24)

U.S. Pharmacopeia – Scientist IV, Analytical Development Lab (11/11/24)

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NIH National Institute of Diabetes and Digestive and Kidney Diseases – Mass Spectrometrist

Posted: December 17, 2024
Location: Bethesda, MD

The Laboratory of Bioorganic Chemistry (LBC) in NIDDK seeks an experienced mass spectrometrist to support research in the discovery and development of new classes of pharmacological agents. An integral part of this research involves the development and application of modern techniques in organic, medicinal and analytical chemistry. The successful candidate will be responsible for operating and maintaining an advanced research grade LC/MS/MS mass spectrometry resource. The LC/MS/MS data provided by this instrumentation is critical for a wide variety of research areas and supports chemists and chemical biologists engaged in cutting edge biomedical research. The most important role of this position is to be able to operate and maintain the sophisticated and complex HRMS instrumentation in a way that maximizes the quality of the MS data generated and to also make the instrument available to as many scientists as possible.

The following qualifications are required:
PhD in organic chemistry, analytical chemistry, or a mass spectrometry-related field.
Demonstrated ability to work independently as substantiated by scientific publications in mass spectrometry related areas.
Postdoctoral or industry experience in operating and maintaining HRMS and HPLC or UPLC instrumentation.
Knowledge of organic chemistry and the ability to use MS or MS/MS data to help determine structures and yield and/or success of reactions or enzymatic transformations.

Preferred experience or qualifications include the following:
Experience with performing accurate mass measurements on molecules ranging from small, synthetic, organic, drug-like compounds; peptides and natural products in the 1-5 kDa molecular weight range; synthetic oligomers such as nucleic acids and peptide nucleic acids (PNAs); nanobodies and antibodies and their chemical conjugates with mwt ranges up to 80 kDa; and glycosylated molecules with a large mwt range.
Demonstrated ability to work as part of a team and to provide rapid turnaround of HRMS data Experience with leading a MS facility or resource and tracking users, sample types, and methods used

Contact Carole Bewley at caroleb@nih.gov with a CV, bibliography, statement of interest and experience relative to the job, and a list of 3 references.
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U.S. Pharmacopeia – Scientist IV, Analytical Development Lab

Posted: November 11, 2024
Location: Rockville, MD

Brief Job Overview
The Scientist IV is a non-supervisory, technical position in USP’s Analytical Development Laboratory directly reporting to a team lead or a lab manager. The scientist is responsible for working on projects related to the research, evaluation, development, and validation of procedures that directly support creation/revisions of monographs, general chapters, or other USP products and solutions related to small molecule and biologic drug substances/drug products, dietary supplements, food ingredients and excipients. The Scientist IV has experience in various analytical techniques, more specifically in chromatography and spectroscopy. The incumbent can troubleshoot, possibly guide, and provide input on difficult projects, while drawing independent conclusions about the results. This is an onsite hands-on position, which requires most of the work in the laboratory.

How will YOU create impact here at USP?
In this role at USP, you contribute to USP’s public health mission of increasing equitable access to high-quality, safe medicine and improving global health through public standards and related programs. In addition, as part of our commitment to our employees, Global, People, and Culture, in partnership with the Equity Office, regularly invests in the professional development of all people managers. This includes training in inclusive management styles and other competencies necessary to ensure engaged and productive work environments.

The Scientist IV has the following responsibilities:
Laboratory work [80%]
Work independently, or with little guidance, to evaluate, develop, and validate analytical procedures for the identification, assay and organic impurities analysis for small molecule and biologic drug substances/drug products, dietary supplements/botanicals, food ingredients and excipients.
Strong understanding of LC-MS technical principles, hands-on experience operating LC-MS equipment and other chromatographic (HPLC, UPLC) techniques.
Plan and implement experiments, provide input on/draw conclusions, and clearly communicate the results with the project team.
Assess submitted procedures based on the method verification work and support the review of the final draft of the procedure.
Routinely apply personal experience, academic training, and insights to address technical problems.
Collaborate in a team setting to achieve goals.

Training, Cross-Collaboration and Continuous Learning [20%]
Demonstrate a strong desire to continue learning, and proactively seek opportunities to grow personal capability.
May participate and/or present at internal and external scientific meetings.
May train staff in processes, techniques, and instrumentation.
May recommend and implement creative approaches or processes to improve laboratory operations.

Who is USP Looking For?
The successful candidate will have a demonstrated understanding of our mission, commitment to excellence through inclusive and equitable behaviors and practices, ability to quickly build credibility with stakeholders, along with the following competencies and experience:

Scientist IV:
Bachelor’s degree in a scientific field with ten (10) years of confirmed experience, or
Master’s degree in a scientific field with seven (7) years of confirmed experience, or
Ph.D. degree in a scientific field with two (2) years of confirmed experience.
Working knowledge, understanding, and hands-on experience with mass spectrometry methods (LC-MS and LC-MS/MS). Relevant experience with chromatography as well as other general analytical chemistry principles and techniques.
In limited circumstances, an equivalent combination of training or special scientific accomplishments is acceptable in lieu of the years of relevant experience.

Additional Desired Preferences
Knowledge and hands-on experience performing “omics” (such as proteomics) analysis using advanced LC-MS instruments and software.
Experience with quantitative LC-MS/MS is a plus.
Experience working in a fast-paced environment with multi-layered priorities.
Flexible and concurrent management of multiple tasks.
Experience working in the compendial, pharmaceutical and/or biotechnology industry is a plus.
Experience working in GLP or ISO-17025 regulated laboratories are a plus.
Experience working with Sciex LC/MSx, Agilent Openlab, Waters Empower software and Electronic Laboratory Notebook Software is a plus.

Supervisory Responsibilities
None.

Benefits
USP provides the benefits to protect yourself and your family today and tomorrow. From company-paid time off and comprehensive healthcare options to retirement savings, you can have peace of mind that your personal and financial well-being is protected.

Compensation
Base Salary Range: USD $98,375 – $124,125 annually.
Target Annual Bonus: 13%; Varies based on level of role
Individual compensation packages are based on various factors unique to each candidate’s skill set, experience, qualifications, equity, and other job-related reasons.

Apply online here
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