AstraZeneca – Associate Director/Director Mass Spectrometry Proteomics BioPharma Dynamic Omics/CGR (8/24/23)
AstraZeneca – Senior or Associate Principal Data Scientist – Mass Spectrometry Proteomics/Metabolomics (8/24/23)
Posted: January 15, 2024
Location: Silver Spring, MD
An ORISE postdoc research fellow position is immediately available at Division of Product Quality Research, Office of testing Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration in Silver Spring, MD. The candidate will work with staff scientists on projects characterizing therapeutic peptides and proteins using high resolution mass spectrometry. Hands-on experience with Orbitrap and/or Q-TOF mass spectrometer is preferred, and research expertise on hydrogen-deuterium exchanging mass spectrometry will be a plus. The qualified fellow will receive competing stipend (salary) and benefits. Please submit a resume to Mack Shih (Mack.firstname.lastname@example.org) and/or Jinhui Zhang (Jinhui.email@example.com). Feel free to contact us for any questions related to this opportunity and we look forward to discussing with you.
Posted: December 15, 2023
Location: Washington, DC
Open & Closing Date: 12/15/2023 to 12/29/2023
Pay scale & grade: GS 12
Salary: $94,199 to $122,459 per year
This position is in the Scientific Research (CL-SR) department of the National Gallery of Art. The primary purpose of the Conservation Scientist position is to support the mission of the CL-SR department by applying scientific expertise to analyze and investigate art-related materials, contribute to the development of conservation strategies, and push the boundaries of scientific knowledge in the context of art preservation. As the Physical Scientist, you will:
• Evaluate requests for analysis from conservators, conservation scientists and curators and recommend appropriate chromatographic/separation techniques and may also include microscopy, imaging, or spectroscopic methods.
• Act as lead scientist to undertake analyses, using a variety of skills in chromatographic methods, and as required, microscopy, spectroscopy, or other types of analysis.
• Advise staff, contract employees, fellows, and interns in the best practices of use of conservation science equipment and instructs and assist them in the interpretation of resulting data.
• Conduct research related to the understanding and preservation of tangible cultural heritage with a focus on the National Gallery’s collections and on conservation and treatment methods.
• Initiate and collaborate on research projects to develop and improve analytical methods for the identification of artists’ materials and to improve the quality of materials and procedures for treating and preserving works of art.
• Author technical reports and publishable papers for scientific and humanities audiences, prepare and deliver public lectures and demonstrations.
To apply, please visit:
https://www.usajobs.gov/job/765834700 (Job Announcement NGA-23-037-DE) for United States citizens, Nationals, or those who owe allegiance to the U.S.
https://www.usajobs.gov/job/765836600 (Job Announcement NGA-23-037-MP) for United States citizens, who are individuals with disabilities, current or former federal employees, career transition (CTAP, ICTAP, RPL), and others as defined in federal hiring regulations.
This is a Federal position; candidates must be U.S. citizens, Nationals, or those who owe allegiance to the U.S. Applications must be submitted on-line through USAJOBS.gov and will be accepted December 15, 2023 to December 29, 2023.
Posted: October 24, 2023
Location: Gaithursburg, MD
Do you have expertise in, and passion for mass spectrometry-based proteomics and biomarker discovery in cardiovascular diseases? Would you like to apply your expertise to impact the biomarker discovery in a company that follows the science and turns ideas into life changing medicines? Then join the Dynamic Omics team at AstraZeneca and unlock the power of what science can do.
About our Postdoc Programme
Bring your expertise, apply your knowledge, follow the science, and make a difference. AstraZeneca’s Postdoc Programme is for self-motivated individuals looking to deliver exciting projects in an encouraging, engaging, and innovative environment. You’ll work with multidisciplinary scientific teams from a diverse set of backgrounds and a world-class academic mentor specifically aligned to your project. Our postdocs are respected as specialists, encouraged to speak up, and supported to share their research at conferences, publish papers, achieve their goals.
Make a more meaningful impact in your career, with greater ownership and accountability to make a contribution whilst making a difference to the lives of our patients!
This is a 3-year programme.
About the Opportunity
The purpose of this position is to provide early-career researchers with an opportunity to further develop their expertise and skills in the field of proteomics, specifically in the context of cardiovascular diseases. Postdocs play a crucial role in advancing scientific knowledge and driving innovation in the pharmaceutical industries.
The successful postdoc will join AstraZeneca’s Dynamic Omics team, a part of the Centre for Genomics Research (CGR) and Discovery Sciences within AstraZeneca. Discovery Sciences provides high quality hits, leads and drug candidates to AstraZeneca project teams. Our use of advanced omics capabilities continues to drive target validation and identification efforts as we continue to evolve the way that we create new leads for the next generation of medicines. As a member of the Dynamic Omics team under Discovery Sciences, the postdoc will be actively involved in preclinical and clinical studies using high-throughput proteomics workflows and advanced bioinformatics.
This project will conduct pioneering research in heart failure diseases by applying pioneering mass spectrometry-based proteomics tools. Our postdoc will collaborate with experienced AstraZeneca’s interdisciplinary scientists in different areas including and mass spectrometry, bioinformatics, molecular biology, cardiology and animal physiology, and an extraordinary academic mentor specifically aligned to the project. The postdoc will have opportunities to develop career aspirations in an extremely supportive and collaborative environment and make a significant scientific contribution to the field of cardiovascular proteomics research.
Supported by Sophia Chung, Senior Scientist, Clinical Omics at AstraZeneca, you’ll also receive academic mentorship and guidance from David A Kass, Johns Hopkins University School of Medicine, Cardiology. The position is located at our R&D site in Gaithersburg, United States.
What You’ll Do
We are looking for scientists with the essential skills and qualifications, track records of academic achievements, easy-to-communicate, approachable personnel, and great collaborators.
This role will primarily lead proteomics projects within Dynamic Omics, CGR, and will be supported by CVRM (Cardiovascular, Renal and Metabolism). The successful postdoc will have the opportunity to work and grow in a fast-paced environment.
Key Duties & Responsibilities:
Operating, maintaining, and troubleshooting liquid chromatography-mass spectrometry instrumentation (LC-MS/MS) (e.g. Astral, Ascend, timsTOF)
Developing and applying all aspects of bottom-up proteomics and PTM proteomics workflows including experimental design, sample preparation, data analysis, and summarizing data for presentations and publications with accountability for accuracy
Leading the development and optimization of PTM enrichment methods
Optimizing and applying new technological and data analysis platforms
Designing and performing cell- or animal-based assays in lab and process various types of samples (e.g. cells, tissues or human samples)
Leading manuscript publication, demonstrating creative and independent scientific thinking to solve complex technical and scientific problems.
Qualifications, Skills & Experience
PhD, or equivalent in biochemistry, analytical chemistry, chemistry, medicine, pharmacology or biology/chemistry-related fields
Extensive experience in mass spectrometry-based proteomics applications
Strong theoretical understanding of analytical chemistry and practical knowledge of instrument interfaces
Experience with a variety of omics data analysis and bioinformatic tools, including commercial software and programming languages
Hands-on experience in basic biochemistry or biology assays/experiments.
Hands-on experience on Orbitrap or timsTOF platforms
Experience in PTM analyses, such as sample processing, MS acquisition, and data analysis for PTM site localization
Expertise in DIA workflow or multi-omics integrated analysis
Experience in molecular biology experiments (e.g. IP, co-IP, tissue cultures, gene editing, KO/OE, PCR, imaging), and familiarity with software tools to design the experiments
Strong background in heart failure or related diseases
Reasons to Apply
This is a fantastic opportunity to collaborate with experts in proteomics, genomics (CGR), and cardiovascular disease area, grow as a scientist, develop your career in a broad scientific community, and publish high-impact publications. You will lead projects and have access to the latest version of instruments, precious and valuable cohorts and develop pioneering techniques.
We will empower you to take appropriate risks and lead the project whilst providing you with the support you need from the multi omics groups, CVRM and the academic supervisor; a leading clinician-researcher in the heart failure field, with a distinguished career spanning over two decades.
As a key member of a research group and taking a leading role on a Postdoctoral project, we expect regular attendance – a minimum of 3 days per week on the AstraZeneca campus. For laboratory-based scientists, this may be higher.
Given the unique positioning of our Postdoctoral researchers, you may have an additional opportunity to spend some time with an external academic mentor. In this instance, you may be required to spend some of your time working alongside them at their facility as driven by the research project. Your flexibility to meet the needs of the research and the scope of the project is required, and we also look to support you with flexibility in accordance with our standard work policies.
This advert will be running from Monday, 23rd October 2023 and, we welcome your application as soon as possible, but ahead of the scheduled closing date of Sunday, 14th January 2024. In the event, that we identify suitable applicants ahead of the scheduled closing date, we reserve the right to withdraw the vacancy earlier than published.
Find Out More
AZ’s Postdoc Programme: https://careers.astrazeneca.com/postdocs-astrazeneca
Life at AstraZeneca: https://careers.astrazeneca.com/life-at-astrazeneca
This is what we’re made of: https://www.youtube.com/watch?v=pmFx_jr2eFo&t=2s
Posted: September 12, 2023
Location: Frederick, MD
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.
Work independently and collaboratively with scientists to perform liquid chromatography-mass spectrometry (LC-MS)-based proteomics experiments, including: protein extraction/digestion, immunoprecipitation, solid-phase extraction (SPE), buffer preparation, enrichment, etc. following established SOPs
Help operate and maintain state-of-the-art LC-MS instrumentation (SCIEX 7500 and Thermo TSQ Altis) and ensure high quality data generation for targeted proteomics
Perform comprehensive data analysis using a variety of methods and software, such as Skyline, Excel, R, Python, etc.
Establish (design, test, and write) new or modify/optimize existing detailed technical SOPs
Document experimental results in a reproducible manner
Analyze, interpret, and effectively present data to team members and collaborators
Comply with all safety procedures and policies
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
Possession of a Bachelor’s degree in biochemistry, analytical chemistry or other related discipline from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Additional qualifying experience may be substituted for the required education. Foreign degrees must be evaluated for U.S. equivalency
In addition to educational requirement, a minimum of eight (8) years of related laboratory experience is required
Both theoretical and hands-on experience in MS-based targeted (MRM and/or PRM) proteomics, including but not limited to: separation chemistry, sample preparation, LC-MS operation and troubleshooting, and data analysis
Detail-oriented, highly-collaborative, self-motivated, and team-oriented
Excellent verbal communication skills
Ability to obtain and maintain a security clearance
Candidates with these desired skills will be given preferential consideration:
Master’s degree in biochemistry, analytical chemistry or other related discipline from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Additional qualifying experience may be substituted for the required education. Foreign degrees must be evaluated for U.S. equivalency
6 years of related post graduate MS-based proteomic experience
Experience operating a SCIEX 7500 and/or Thermo TSQ Altis
Experience operating a Waters M-Class UPLC, and/or Thermo UltiMate nanoLC (i.e., microflow or nanoflow LC, respectively)
Experience with Skyline software
Experience with Covaris ultrasonicators and/or liquid handlers
Experience performing global proteomics experiments
Familiarity with CLIA requirements
Apply online at https://leidosbiomed.csod.com/ux/ats/careersite/4/home/requisition/3693?c=leidosbiomed
Posted: August 24, 2023
Location: Gaithursburg, MD
Summary of the Group
We are part of the Centre for Genomics Research (CGR) and Discovery Sciences within AstraZeneca, and work across all therapeutic areas: Oncology, Cardiovascular, Renal and Metabolism (CVRM), Respiratory and Immunology (R&I), Vaccines and Immunotherapies (V&I), Neurosciences, and Rare Diseases.
We deliver key data to projects across all phases of drug discovery and development, and works with all modalities from small molecules to biologics. The Associate Director/Director of the Proteomics team provides leadership, mentorship, and technical guidance to mass spectrometry-based proteomics scientists to advance the team’s data delivery to AstraZeneca’s robust drug portfolio. This is a partial lab-based role with a leadership role for a minimum of four scientists (Associate Director) or eight scientists (Director). Establish efficient proteomics workflows together with other leaders and provide guidance on fit-for-purpose proteomics experiments. Work closely with muti-disciplinary teams to support projects from idea conception through proof-of-concept and delivery of drug candidates. Lead efforts developing new proteomics techniques to stay at the for front of the industry. Seek opportunities to improve the efficiency and success of proteomics workflows and collaborate with other teams in CGR using the power of automation, ML and AI. Provide expertise to different therapeutic area partners driving the understanding of the biology of the disease through proteomics analyses. Update proteomics lab infrastructure continuously, streamline lab workflows, and work with scientists to improve data capture and management.
This role will primarily lead scientists in collaborations with our therapeutic areas. The successful candidate will have the opportunity to work and grow in a fast-paced environment under the supervision of senior staff members.
Responsible for oversight of mass spectrometrists/proteomics experts.
Responsible for proteomics workflows from experimental design, mass spectrometry techniques, and data analysis of pre-clinical and clinical studies.
Provide mentorship to other team members.
Modernize instrumentation continuously.
Summarize data for presentations, reports, and publications with accountability for accuracy. Review and approve proteomics data and reports to ensure quality and integrity.
Lead collaborations and communicate effectively with authorities from various technical backgrounds.
Operate effectively in a multidisciplinary matrix research environment, providing leadership and insight.
Influence through initiatives, presentations, publications, governing bodies and consortium activities,
Ensure that work is conducted in a safe and compliant manner; maintain lab documentation, establish SOPs and/or practice in accordance with established SOPs, GLP requirements.
Education and Experience Requirements:
PhD or equivalent in bioanalytical chemistry, proteomics, or relevant subject area, with extensive relevant scientific experience.
Experience leading PhD level scientists in mass spectrometry/proteomics with significant hands-on experience to operate, maintain, and troubleshoot nano liquid chromatography-mass spectrometry instrumentation (timsTOF Pro2, timTOF SCP, Orbitrap Ascend, and/or Exploris 480), following best industry practices.
Lead collaborations and advance projects by standardizing the design of experiments, analysis and interpretation of data from of our preclinical and clinical studies, and summary of experimental results for presentations, review for accuracy and write reports and high-quality/high impact scientific publications.
Experience with a variety of proteomic data analyses and bioinformatic tools, including commercial software and/or programming such as R or Python.
Strong multi-tasking, time management, organizational skills and excellent communication skills, both verbal and written.
Proven ability to lead by example with honesty, integrity, flexibility, creativity, and collaborative spirit thereby building successful teams.
Ability to handle multiple projects and/or tasks in a fast-paced environment.
Experience with establishing automated lab processes.
Experience with Genedata Profiler
Experience with multiomic integration and working with data scientists creating data analysis platforms
Extensive experience with setting goals and objectives, motivating and developing scientists and influencing recruitment of successful teams
Education and Experience Requirements:
PhD or equivalent in bioanalytical chemistry, proteomics, or relevant subject area, with extensive relevant scientific and 5-year industry or center of excellence experience in a similar role.
Essential required skills: (all criteria listed for Associate Director role plus the following):
Lead the proteomics strategy to develop and optimize new proteomic technologies in line with industry practices.
Consistent track record establishing new capabilities by working with data scientists to assist creating data analysis platforms harnessing the power of automation, ML and AI.
Recognized authority in the field with internal and external influence through initiatives, presentations, publications, governing bodies, and consortium activities.
Effective stakeholder leadership skills.
Successfully leading high-impact publications.
Apply online at https://careers.astrazeneca.com/job/gaithersburg/associate-director-director-mass-spectrometry-proteomics-biopharma-dynamic-omics-cgr/7684/53403250608
AstraZeneca – Senior or Associate Principal Data Scientist – Mass Spectrometry Proteomics/Metabolomics
Posted: August 24, 2023
Location: Gaithursburg, MD
This role is within the Center for Genomics Research (CGR). We are looking for a computational proteomics scientist to support the growing bioinformatics needs of the Dynamic Omics team in the Centre. You will join the CGR Informatics Team and contribute with your bioinformatics and statistical expertise to the CGR’s multidisciplinary research environment comprised of computational biologists, genomics, proteomics and metabolomics/lipidomics scientists, software engineers, statistical geneticists, disease area specialists and clinician experts.
You will be considered for roles as a Senior Scientist or Associate Principal Scientist dependent on your skills and experience.
What you will be doing on daily basis? As a Senior or Associate Principal Scientist, you will be…
actively involved in mass-spectrometry based proteomics and metabolomics data generating, processing, analytics and visualisation to generate insight into biological questions in support of our research
providing bioinformatics support on an extensive portfolio of proteomics, metabolomics, and lipidomics projects including statistical experiment design, hypothesis testing and data analysis to colleagues and collaborators
communicating technical results and biological interpretation to colleagues and collaborators
As the Associate Principal Bioinformatics Scientist, you will additionally be comfortable with:
integration of multi-modal omics data to interpret disease biology and disease mechanisms
applying data science methods (AI, ML, knowledge graphs) to better understand complex biological data
working hands-on with industry leading technologies as our informatics capabilities are fully cloud-based and were designed to handle the analysis of large-scale mass spectrometry data aiming to reach up to 2 million genomes and 50,000 proteomes and metabolomes/lipidomes by 2026.
To help with the decision, here are some skills we will be looking for while reading your CV:
your overall experience with all aspects of mass-spectroscopy based proteomics and/or metabolomics
your demonstrable experience in one or more of the following core competency areas: multivariate and/or high dimensional data analysis across OMICs, advanced data visualization, statistical data analysis and interpretation
your familiarity with biological networks, their analysis and display.
how you communicate with team members and non-experts, both verbally and through reports and documentation
coding skills appropriate for data analysis and visualization
your motivation to work within a dynamic team in a quickly evolving research environment.
For the Associate Principal Bioinformatics Scientist, we will be additionally looking for:
your previous involvement in a large-scale public, industry or academic omics initiatives, preferably mass spectrometry-based proteomics/metabolomics experience and, importantly, placing it in a biological context
your track record of peer-reviewed publications in high-level scientific journals
And in any case, you can impress us with:
your experience with bridging the gap between the MS experimental data collection, analysis to biological interpretation usingdata science and advanceanalytics methods in genomics, proteomics, and/or metabolomics/lipidomics in an early drug discovery and validation R&D.
strong relationships with scientific communities.
Apply online at https://careers.astrazeneca.com/job/gaithersburg/senior-or-associate-principal-data-scientist-mass-spectrometry-proteomics-metabolomics/7684/53148739904
Posted: July 11, 2023
Location: College Park, MD
The Office of Regulatory Science of the U.S. Food and Drug Administration’s (FDA) Center for Food Safety and Applied Nutrition (CFSAN) is seeking an outstanding analytical or bioanalytical chemist with mass spectrometry expertise to participate in our food safety research program. An opening for a postdoctoral research fellow is available in the Bioanalytical Methods Branch. The position will involve the development and validation of methods for the identification of emerging chemical residues in foods and dietary supplement products using mass spectrometry (MS)-based techniques (i.e., LC-MS and/or GC-MS).
A Ph.D. degree in Analytical Chemistry, Bioanalytical Chemistry, or related fields, with a strong background and interest in MS instrumental analysis, is required. Candidates should be experienced with the latest liquid chromatographic and mass spectrometric techniques including data acquisition and processing, compound identification, and small molecule quantitation. Training in non-targeted analysis (NTA) including experience in NTA software tools (e.g., Compound Discoverer software, Global Natural Products Social Molecular Networking), is also highly desirable.
U.S. citizenship, permanent resident status, or a valid J1 Visa is required. Applicants must have resided in the United States for at least 36 of the previous 60 months to be eligible. A successful background investigation is also required. The position is located in College Park, Maryland.
Interested candidates should submit a curriculum vitae, a list of references, and a cover letter that includes a short statement of experience and research interests via email to: Christine Parker, Chief, Bioanalytical Methods Branch (Christine.Parker@fda.hhs.gov).