Speaker: Stephen Valentine, West Virginia University

Topic: Developing Next-Generation Tools for Native Mass Spectrometry

Date: Monday, December 12, 2022

Time: 6:15 pm Dinner, 7:15 pm Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)
This will be an in-person meeting. Attendees are required to show a vaccine card (either at the door or in advance using the web form) . If you have submitted your vaccine card before, your status is already recorded.

Dinner: Please RSVP to Andy Qi (andy.yue.qi@gmail.com) by Friday, December 9 if you will be attending the dinner.

Abstract: Native mass spectrometry (MS) is a powerful approach for structuralelucidation of large biomolecules. A number of technical and instrumental advances have enabled studies of diverse species ranging from protein machines to whole virus particles. However, biomolecules such as partially structured/unstructured proteins present a particular challenge to native MS. This presentation describes the development of new ionization technology with advantages in sensitivity and functionality for the study of these challenging molecules. The methods offer the best opportunity to study biomolecule conformer formation with broad implications for the study of disease processes and the development of therapeutics.

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