Speaker: Alan G. Marshall, Florida State University

Topic: Ultrahigh Resolution Mass Spectrometry: Extending the Size and Detail of Biomolecule Structure Analysis

Date: Monday, September 18, 2017

Time: 6:00 pm Dinner and Vendor Show, 7:15 pm: Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Confirmed Vendors for Show: Advion, Agilent, Bruker, Cambridge Isotope Labs, Gerstel, JEOL, LECO, MassTech, Peak Scientific, Phenomenex, Restek, Sciex, Shimadzu, Thermo Fisher Scientific chromatography, Thermo Fisher Scientific mass spectrometry, and Waters

Dinner: Please RSVP to Stefani Thomas (sthoma92@jhmi.edu) before Friday, September 15, if you will be attending the dinner or are presenting as a vendor.

Abstract: Most mass analysis relies on “nominal” mass accuracy (i.e., to within 1 Da). However, more and more applications are based on much more accurate mass measurement. High mass resolving power (m/Δm50% > 500,000 over a wide mass range) offers two major advantages. First, it becomes possible to separate complex mixtures without prior chromatographic or gel separation. Second, elemental composition may be determined from accurate (to ~100 ppb) mass measurement alone for unknown molecules up to ~1,000 Da. Examples include protein post-translational modifications and site-specific redox potentials, lipidomics, metabolomics, and mapping contact surfaces in protein assemblies for drug targets. Fourier transform ion cyclotron resonance mass spectrometry offers 10-100x higher mass resolution than other mass analyzers. [Supported by NSF DMR-11-57490 and the State of Florida.]