Saturday, September 22nd, 2018

Meetings

Thermo Users Meeting

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39th East Coast Ion Chemistry Conference

The 39th East Coast Ion Chemistry Conference, ECICC, will be held on Saturday, October 13 in 219 Brown Lab at the University of Delaware. You and your co-workers are invited to attend. There will be refreshments and opportunities for discussion and conversations.

Talks have been given at past meetings on instrumentation (MALDI, TOF, ICR, ESI, GC/MS, API, PIAMS), ion molecule reactions, calculations, and chemical analyses. Attendance in recent years has been 30 – 40 and the presentations have lasted from ~9 am until shortly after noon.

Please let us know if you want to give a TEN (10) minute talk on one aspect of your research – not a survey of work done in the last year. We encourage presentations by graduate and undergraduate students. There is no charge to attend the meeting or to give presentations.

We would appreciate a response by the first week in October. All we need is your name, affiliation and (if you are giving a presentation) the title of your talk. No abstract is required. Titles will be accepted through noon on Thursday, October 11. The meeting is informal, but we do need a schedule. Please respond to bmunson@udel.edu.

A parking map for the University of Delaware is here. There is a large (pay, unfortunately) parking garage on Academy Street, near Brown Lab.

We hope that you will be able to attend and present some of your work.
Murray Johnston, Burnaby Munson, Doug Ridge

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September 2018 Meeting and Vendor Night

Speaker: Richard van Breemen, Oregon State University

Topic: Advances in Affinity Selection Mass Spectrometry for Characterizing Active Compounds in Natural Product Mixtures – Late-breaking update on anticoagulant contamination of synthetic cannabinoid products in Illinois

Date: Monday, September 17, 2018

Time: 6:00 pm Dinner and Vendor Night, 7:15 pm Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Yan Wang (yanwang@umd.edu) by Friday, September 14th if you will be attending the dinner.

Abstract: As faster alternatives to bioassay-guided fractionation, various affinity selection-mass spectrometry (AS-MS) methods have been developed and used for the isolation, characterization and identification of pharmacologically active compounds in complex natural product mixtures such as botanical and microbial extracts. The most successful of these approaches include size exclusion chromatography LCMS (SEC MS), pulsed ultrafiltration (PUF-MS), and magnetic microbead affinity selection screening (MagMASS). The throughput of these MS-based methods was enhanced over 100-fold by incorporating multititer well plate format, automated sample preparation, UHPLC, and automating data analysis using metabolomics software.
Our on-going collaboration with Douglas Feinstein at the University of Illinois at Chicago concerning rescue therapy for superwarfarin overdoses will be updated in view of the >200 poisonings and 7 deaths reported thus far in Illinois, Wisconsin and Maryland. In preclinical studies, UHPLC-MS/MS was used to investigate the metabolism and elimination of the superwarfarin rodenticide brodifacoum. In support of the 2018 poisonings caused by adulteration of illicit synthetic cannabinoids sold in multiple states as “K2” and “Spice”, we modified our UHPLC-MS/MS method to detect, identify and quantify multiple superwarfarins in serum from hospitalized victims.

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