Meetings

Notices

1. June 24, 2013 MSDG Meeting at Shimadzu Training Center in Columbia

Post-ASMS Poster Session and Dinner with Presentations by Travel Award Recipients

2. 2013 MSDG Young Investigator Award Recipients

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June MSDG Meeting

Topic: Post-ASMS Poster Session and Dinner with Presentations by Travel Award Recipients

Date: Monday, June 24, 2013

Time: 6:00 pm Dinner and Poster viewing; 7:30 pm: Presentations by Award Recipients

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner and Poster: Please RSVP to Peter Nemes (Peter.Nemes@fda.hhs.gov) by June 19 if you will be attending the dinner or presenting your ASMS poster.

2013 WBMSDG Young Investigator Travel Award Recipients

Lissa C. Anderson, University of Virginia:
Advisor: Professor Donald F. Hunt. Abstract title: Covalent Labeling Strategies for the Improvement of Whole Protein and Large Peptide Sequence Determination by Electron Transfer Dissociation.

Waeowalee Choksawangkarn, University of Maryland:
Advisor: Professor Catherine Fenselau. Abstract title: Use of Iron Oxide Nanoparticle Pellicles for Enrichment of Plasma Membrane Proteins from Suspended Cells.

Hang Li, George Washington University:
Advisor: Professor Akos Vertes. Abstract title: Ambient Molecular Imaging and Quantitative Analysis by Laser Ablation Electrospray Ionization Mass Spectrometry with Ion Mobility Separation.

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May Meeting

Speaker: Tom Phillips, Ph.D., Maryland Department of Agriculture, Annapolis, MD

Date: Monday, May 20, 2013

Time: 7:30 pm

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please join the speaker and the co-chairs for dinner at the Ram’s Head Tavern at Savage Mill, 8600 Foundry Street, Savage, MD 20763 at 5:30 pm. Contact Peter Nemes (Peter.Nemes@fda.hhs.gov) to let him know you will be there for dinner.

Abstract: Since the acquisition of our first hyphenated instrument in 2004, we have had several problematic matrices.  These matrices have made quantitation of known compounds and identity confirmation very difficult.  Matrix-dependent signal suppression or enhancement, or matrix effects (ME), represents a major problematic area in hyphenated techniques and are dependent upon the ionization technique used.  Whether electrospray ionization (ESI), atmospheric pressure ionization (API) or a combination of the two, ESCI, matrix effects occur and are difficult to resolve.  ME can heavily affect the reproducibility, linearity and accuracy of a quantitative method and lead to incorrect quantitation.  The exact mechanism for ME is still unknown, it is commonly assumed that the co-eluted matrix can influence signal intensity in a possible competition for available charges and for access to the droplet surface for gas-phase emission.  Several case studies will be presented that show both enhancement and suppression, and what was done to reduce and in some cases alleviate the ME.

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