Speaker: Douglas P. Ridge, Ph.D., University of Delaware
Topic: Fourier transform ion cyclotron resonance studies: Examples including Infra-red multiphoton dissociation studies of cadmium sulfide metal clusters
Date: Monday, October 17, 2016
Time: 6:15 pm Dinner, 7:15 pm Presentation
Location: Gerstel/Agilent Office, 701 Digital Drive #J, Linthicum Heights, MD 21090 (Directions)
Dinner: Please RSVP to Katherine Fiedler (Katherine.L.Fiedler@fda.hhs.gov) before October 17 if you will be attending the dinner.
Abstract: Fourier transform ion cyclotron resonance mass spectrometry involves injecting ions into an electromagnetic trap where they can be detected and mass analyzed on the basis of their cyclotron frequency. The method facilitates manipulating the trapped ions in various informative ways. The reactivity of trapped ions can be examined by exposing the trapped ions to reactive gases. Structure and spectroscopic properties can be examined by subjecting the trapped ions to collisional or photon induced decomposition. Examples of the applications of these techniques will be described. In particular the application of these techniques to the study of Cadmium sulfide metal clusters will be described. These metal clusters are important in marine environments both as potentially toxic pollutants and in relation to the exotic biology found around hydrothermal vents in the ocean floor. Although cadmium sulfide is insoluble in water metal sulfide clusters can be prepared by electrospraying soluble metal salts such as cadmium acetate and allowing the resulting cadmium acetate clusters to react with H2S in the ion trap. This results in clusters containing multiple Cd atoms and bisulfide and sulfide counter ions. The structure of these clusters have been probed by subjecting them to collision induced decomposition, IR multiphoton dissociation, and density functional theory calculations. Among the conclusions is that when excited the clusters tend to lose preferentially metal atoms forming a series of clusters containing hypervalent polysulfides.Read more of this article
Date: October 1, 2016
The 37th East Coast Ion Chemistry Conference, ECICC, will be held on Saturday, October 1 in 219 Brown Lab at the University of Delaware. You and your co-workers are invited to attend. There will be light refreshments and opportunities for discussion and conversations.
Talks have been given at past meetings on instrumentation (MALDI, TOF, ICR, ESI, GC/MS, API, PIAMS), ion molecule reactions, calculations, and chemical analyses. Attendance in recent years has been 30 – 40 and the presentations have lasted from ~ 9 am until shortly after noon.
Please let us know if you want to give a TEN (10) minute talk on one aspect of your research – not a survey of work done in the last year. We encourage presentations by graduate and undergraduate students. There is no charge to attend the meeting or to give presentations.
We would appreciate a response by the middle of September. All we need is your name, affiliation, and (if you are giving a presentation) the title of your talk. No abstract is required. Titles will be accepted through noon on Thursday, September 28. The meeting is informal, but the program looks better if there are titles for the talks.
We hope that you will be able to attend and present some of your work. The mailing list is much-reduced from previous years. Please forward this invitation to others at your institution whose names are not on our email list.
Please respond to email@example.com.
Murray Johnston, Burnaby Munson, Doug Ridge, Papa-Nii Asari-Okai
Speaker: David Muddiman, North Carolina State University
Topic: Innovative Chemistries and Technologies to Read the Complex Language of Biology (following vendor show)
Date: Monday, September 12, 2016
Time: 6:00 pm Vendor Show and Dinner
7:15 pm: Presentation from David Muddiman
Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)
Dinner: Please RSVP to Katherine Fiedler (Katherine.L.Fiedler@fda.hhs.gov) before September 12 if you will be attending the dinner or are a presenting as a vendor.
Abstract: Mass spectrometry offers the most robust platform to discover and characterize new diagnostic, prognostic, and therapeutic biomarkers for ovarian cancer across all molecular classes. Moreover, a systems biology approach will allow the underlying biology and origin of ovarian cancer to be understood. This presentation will discuss the challenges specific to the study of epithelial ovarian cancer (EOC) in humans and how these challenges have directed our thinking in terms of the development of model organisms and mass spectrometry-based bioanalytical strategies. First, to augment the human model, we developed the domestic hen model of spontaneous EOC, which allowed us to longitudinally sample the rapid onset and progression of the disease in a controlled environment. Second, we developed bioanalytical tools to characterize structurally challenging analytes that are critical to a systems-level analysis. To increase the electrospray response of N-linked glycans, we synthesized novel hydrophobic tagging reagents which have the added benefit of being able to incorporate a stable-isotope label for relative quantification experiments (INLIGHTTM). Furthermore, we developed a novel ionization technique for tissue imaging of lipids and metabolites. This unique model organism has and continues to provide new insights into the biology of ovarian cancer; combined with other –OMICS data obtained through these novel bioanalytical approaches, we will understand the origin of ovarian cancer and ultimately translate that knowledge to humans.
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