Thursday, October 23rd, 2014

Meetings

Notices

1.Wednesday, October 15, 2014 Meeting in Columbia; Professor Gary L. Glish, UNC-Chapel Hill; Topic: The New Tandem MS: Ion Mobility Spectrometry/Mass Spectrometry

2. In memoriam, Joseph Campana, Ph.D.

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October 15 (Wednesday) Meeting

Speaker: Professor Gary L. Glish, University of North Carolina-Chapel Hill

Topic: The New Tandem MS: Ion Mobility Spectrometry/Mass Spectrometry

Date: Wednesday, October 15, 2014

Time: 6:15 pm: Dinner and Social Hour; 7:15 pm: Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner and Social Hour Please RSVP to Asher Newsome (graham.newsome.ctr@nrl.navy.mil) if you will be attending dinner.

Abstract:

Tandem mass spectrometry (MS/MS) is one of the most powerful methods available to the modern analytical chemist. However, as instruments become more and more sensitive there is an increasing challenge of isomeric and isobaric ions interfering with the analysis. The conventional approach to overcoming this problem is to use chromatography to separate analytes prior to ionization. While LC is a powerful analytical technique in its own right, it has some limitations when combined with mass spectrometry. A couple of important limitations are that the time frame of a chromatography separation is much slower than mass spectrometry (minutes to hours vs. seconds or less), and the order of analyte analysis cannot be adjusted in real‐time. Perhaps more importantly, for some real‐time analyses chromatography is not even an option.
As an alternative to chromatographic separations, we are developing differential ion mobility spectrometry (DIMS) as a separation method prior to mass spectrometry. While mass spectrometry separates ions based on their mass‐to‐charge ratio, conventional drift tube ion mobility spectrometry (DTIMS) is based on the ions’ shape‐to‐charge ratio. For DIMS the separation mechanism is not totally understood and while shape‐to‐charge plays a role, other factors such as the ion interaction with the drift gas are important. This makes DIMS more orthogonal to MS than DTIMS. DIMS has other differences compared to DTIMS that make DIMS more useful as an alternative to chromatography when combined with MS. In this presentation the fundamentals of DIMS will be discussed. Examples will be shown using DIMS/MS/MS to analyze isobaric peptides, aerosols in real‐time, and targeted compounds in complex matrices.

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September 2014 Meeting

Topic: Vendor Night Poster Session and Dinner with Presentations

Date: Monday, September 15, 2014

Time: 6:00 pm Dinner and Poster viewing; 7:15 pm: Presentations

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner and Poster: Please RSVP to Asher Newsome (Graham.Newsome.ctr@nrl.navy.mil) by September 12 if you will be attending the dinner or making a presentation.

Corporate Presenters will include:

  • AB Sciex
  • Agilent
  • BioReliance
  • Bruker,
  • Gerstel
  • Ionics
  • JEOL
  • LECO
  • MassTech
  • Peak Scientific
  • Parker Hannifin
  • Phenomenex
  • Shimadzu
  • Thermo Fisher Scientific
  • Waters
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