Posted: September 13, 2021
Location: Baltimore, MD
Research technologist positions are currently available in the Applied Imaging Mass Spectrometry (AIMS)
Core directed by Professor Kristine Glunde at The Johns Hopkins Medical Institutions in Baltimore,
Maryland. The technologist will help develop and run innovative mass spectrometry imaging applications
in diverse biomedical research projects in the fields of oncology, pharmacology, infectious disease,
neurology, radiology, pathology, and plastic surgery. The daily hands-on work of the technologist includes
cryo-sectioning, sample preparation, matrix-assisted laser desorption/ionization (MALDI) imaging, data
analysis, preparation of data reports, as well as maintenance and upkeep of AIMS Core instrumentation
and laboratory facilities. Together with the AIMS Core Team, the technologist will closely work with and
support the users of the AIMS Core, and work with industry partners and instrument vendors in maintaining
and improving the cutting-edge instrumentation in the AIMS Core.
The ideal candidate should hold a Bachelor’s or Master’s degree in Chemistry or a closely related field,
have research experience in analytical chemistry, mass spectrometry, liquid chromatography mass
spectrometry (LC-MS), high performance liquid chromatography (HPLC), and/or MALDI imaging, and a
strong interest in mass spectrometry imaging technology applied to biomedical research. Excellent oral
and written communication skills are required. The successful applicant will work as part of a collaborative
team and use a wide range of cutting-edge instrumentation, equipment, and laboratory facilities in the
AIMS Core on the Johns Hopkins Medical Campus. Opportunities are available to attend and present at
scientific meetings if desired.
If interested, please email your application to Dr. Kristine Glunde at email@example.com.
Posted: September 13, 2021
Location: Baltimore, MD
A postdoctoral position is currently available at the Johns Hopkins University School of Medicine in
Baltimore, Maryland working with Professor Kristine Glunde to develop novel applications for mass
spectrometry imaging. Research in the Glunde Lab focuses on cancer detection, diagnosis, and assessing
treatment response. Mass spectrometry imaging is frequently combined with in vivo imaging approaches
and complementary molecular and biochemical approaches to investigate, test, and develop emerging
biomedical imaging technologies. This position provides plenty of opportunities to develop research skills,
attend meetings, present research projects, and develop skills in grant writing, presenting, and networking.
The ideal candidate should have a strong background in mass spectrometry imaging including sample
preparation, experience in cell and in vivo studies, tissue harvesting and preparation, familiarity with
microscopic and histological techniques, and a strong interest in developing mass spectrometry imaging
technology and applications. We are looking for innovative, motivated, and creative scientists to join our
thriving research team. The successful applicant will work as part of a collaborative team and have access
to a wide range of cutting-edge instrumentation, equipment, facilities, including fully equipped cell and
molecular biology laboratory, as well as the Johns Hopkins Applied Imaging Mass Spectrometry (AIMS)
Core facility on the Johns Hopkins Medical Campus.
Research in the Glunde Lab focuses on cancer metabolism, novel metabolic cancer treatment targets, and
molecular and metabolic imaging of cancer. The Glunde lab is well funded, including several National
Institutes of Health grants. Dr. Glunde has mentored over 45 students, post-doctoral fellows, and junior
faculty and published over 100 publications in the field of cancer metabolism and molecular imaging of
cancer. Dr. Glunde is also the founding director of the Applied Imaging Mass Spectrometry (AIMS) Core
at the Johns Hopkins Medical Institutions (JHMI), making available this highly multiplexed, high throughput
tissue imaging technology to faculty at Johns Hopkins and outside institutions.
The Glunde Lab is a diverse, international, and inclusive team of faculty, postdoctoral fellows, graduate
students, undergraduate researchers, and staff members who engage in open, respectful, and critical
discussions of innovative scientific concepts and evolving research projects. Previous postdoctoral
scholars from the Glunde Lab now hold faculty positions, positions in biomedical government agencies, or
pharmaceutical or biotechnology industry.
If you are interested, please email your application to Dr. Kristine Glunde at firstname.lastname@example.org.
Posted: September 7, 2021
Location: College Park, MD
The Office of Regulatory Science (ORS) of the U.S. Food and Drug Administration’s Center for Food Safety and Applied Nutrition is seeking an outstanding chemist with analytical or bioanalytical expertise to participate in our food safety/food defense research program. An opening for a food safety/chemistry fellow is available in the Bioanalytical Methods Branch. The position will involve the development and validation of methods for the quantification of unapproved compounds, plant toxins, and botanical constituents in dietary supplements using mass spectrometry (MS)-based techniques (i.e. LC-MS and/or GC-MS). A B.S., M.S. or Ph.D. degree in Chemistry, Bioanalytical Chemistry, or related fields, with a strong background and interest in instrumental analysis, is required. Candidates should be experienced with the latest liquid chromatographic and mass spectrometric techniques and application of those techniques to quantitative analysis. Training or experience in analytical method development for complex matrices such as food, cosmetics or environmental analysis is also highly desirable.
Interested candidates should submit a curriculum vitae, a list of references and a cover letter that includes a short statement of experience and research interests via email to: Christine Parker, Chief, Bioanalytical Methods Branch (Christine.Parker@fda.hhs.gov). Please use “Research Fellow 2021” in the subject line.
Posted: September 2, 2021
Location: College Park, MD
The Department of Chemistry and Biochemistry of the University of Maryland, College Park invites applicants for an open-rank tenure-track faculty position, starting August 2022. Candidates with innovative research programs centered in synthetic organic chemistry or bioanalytical chemistry, who will synergize with current faculty in areas that include supramolecular chemistry, chemical biology, proteomics/metabolomics, structural biology and nanotechnology are particularly sought. The criteria for selection will be proven excellence and/or potential for scientific impact through original research, scholarship, and teaching.
Successful candidates will be expected to develop or enhance vigorous externally funded research programs and have a demonstrated commitment to teaching and mentorship at the undergraduate and graduate levels, including working with students and groups from diverse backgrounds. As members of a key department in the College of Computer, Mathematical, and Natural Sciences, Chemistry and Biochemistry faculty participate in major University and federally-funded Centers and Institutes, including the NanoCenter, the Institute for Bioscience & Biotechnology Research (IBBR), the Earth System Science Interdisciplinary Center (ESSIC), the Institute for Physical Science & Technology (IPST).
Scholars with highly acclaimed research programs and demonstrated excellence in education. Candidates must have a Ph.D. degree in Chemistry, Biochemistry or closely related discipline, significant research accomplishments, and experience in teaching/mentoring in the chemical sciences, broadly defined.
Research (examples: research statement, research programs)
Teaching (examples: teaching philosophy, student evaluations)
Apply online at https://ejobs.umd.edu/postings/86776.
Posted: August 3, 2021
Location: Baltimore, MD
The University of Maryland, Baltimore County (UMBC) is seeking a Manager for its Molecular Characterization & Analysis Complex (MCAC), a core facility within the College of Natural & Mathematical Sciences. The MCAC is dedicated to developing cutting edge analytical techniques in order to solve modern problems while providing a stimulating learning environment and exposure to research for both undergraduate and graduate students. Open to universities and all other facilities in need of analytical techniques, the lab strives to be an environment of peer mentoring, professional team building, and a place to develop critical thinking skills by fusing academic research with both teaching and industry.
Reporting to the Assistant Dean of Financial Management, the incumbent will be responsible for overseeing the daily operations of the facility. Specific duties include:
– Leading and working alongside a team of research assistants and student staff to prepare samples and perform laboratory work, including creating dilutions and calibration curves, instrument method development, running analyses on facility instrumentation, interpreting results, and writing reports
– Performing quality control and preventative maintenance on facility equipment, including troubleshooting and performing simple instrument repairs and working with service engineers to diagnose and fix more complex issues
– Supervising and mentoring two staff members, including performance management and professional development
– Performing administrative duties such as reviewing and approving monthly billing for equipment usage and special projects, maintaining electronic notebooks
– Performing other duties as assigned
Requires a Bachelor’s Degree in Biology, Chemistry, or a field of study related to the research of the facility; a minimum of three years of supervisory experience; and strong written and verbal communication skills to effectively communicate to a broad audience. Consideration may be given for a unique combination of education and Biology or Chemistry experience, such as a Bachelor’s Degree in an unrelated field with at least 18 credits in a field related to research in a laboratory, or a Bachelor’s Degree in an unrelated field with at least three years of laboratory experience.
Preferred qualifications: Master’s Degree in a related field; minimum of five years of experience with two or more types of analytical instrumentation, such as NMR, mass spectrometry, spectroscopy, chromatography, thermal, or proteomics; previous experience managing or working in a core facility at a university; strong interpersonal and organizational skills; a commitment to exemplary customer service; and an entrepreneurial spirit to continue and expand the services of the facility.
Starting salary is commensurate with qualifications and experience. This is a full-time position and includes full university benefits.
For best consideration, submit a cover letter, resume, and contact information for three professional references by August 20, 2021, (applications will be accepted until the position is filled) to: http://listings.umbc.edu/cw/en-us/job/493428?lApplicationSubSourceID=11482
Posted: July 19, 2021
Location: Baltimore, MD
The Translational Geroproteomics Unit (TGU) is seeking diverse, highly motivated, and enthusiastic postdoctoral fellows to tackle important questions in aging biology using proteomic approaches. This is a full-time and fully funded primary research fellowship for individuals interested in leveraging mass spectrometry-based proteomics to have a translational impact on age-related diseases linked to hallmarks of aging such as cellular senescence and loss of proteostasis. Postdoctoral fellows will be mentored by Dr. Nathan Basisty, and will have access to a highly interactive, resourceful, and dynamic scientific environment with state-of-the-art instrumentation and ample opportunities for training and career development.
Potential projects: We are looking for postdocs interested in working on various projects, including but not limited to:
– Discovery and validation of ‘proteoform’ (modified proteins and protein isoforms) biomarkers of aging and their relationship with the rate of aging, the development of age-related diseases as well as physical and cognitive disability in human cohort studies such as the BLSA, GESTALT, and InCHIANTI.
– Targeting and quantifying senescent cells and dissecting the functions of heterogeneous senescent cell populations via their surfaceomes (cell surface proteomes)
– Mass spectrometry method development, particularly the development and application of workflows involving data independent acquisition (DIA/SWATH), PTM identification/quantification, and/or protein turnover analysis.
Postdocs are encouraged to independently develop and drive the direction of research projects, as well as establish new research directions.
Training and career development: Fellows will have access to hands-on training in multiple technologies and scientific techniques including mass spectrometry-based proteomics on several high-end instruments, analytical chemistry, cell culture, and mouse work. The NIA offers multiple career development opportunities for postdocs, including opportunities to apply for internal funding through the FARE (Fellows Award for Research Excellence) program, Nathan Shock travel awards, Interlaboratory Funding Proposals, Postdoctoral Fellowship Funding Awards, and the Independent Research Scholar (IRS) Program.
Postdocs are highly encouraged to attend conferences and scientific workshops for career development. Training also includes active participation in weekly multidisciplinary lab meetings, weekly Longitudinal Studies Section (LSS) Meetings, and professional development and research methods courses offered through the NIH Office of Intramural Training and Education (OITE). Fellows are also encouraged to take advantage of the NIH interest groups, particularly the Proteomics Interest Group and the NIA Molecular Biology Interest Group.
Postdocs will also have the opportunity to collaborate on projects with the Baltimore Longitudinal Study of Aging (BLSA), the longest running human aging study in the U.S., as well as other human cohorts (GESTALT, InCHIANTI).
Qualifications: The successful candidate must have a PhD, MD, or equivalent doctoral degree. We are looking for candidates with background and/or a strong interest in one or more of the following areas: mass spectrometry-based proteomics, characterization of PTMs, cell culture, or related fields who are passionate and self-motivated in research. Candidates with prior experience developing and performing mass spectrometry workflows, coding with R or Python, and experience with human or mouse aging models are especially encouraged to apply.
How to Apply: Please email a (i) CV, (ii) cover letter detailing research interest, experience, and career goals, and (iii) three references to Nathan Basisty, PhD at email@example.com.
Compensation: Salary is consistent with NIH guidelines and benefits include health, dental and vision insurances, paid time-off, and conference time.
Posted: July 8, 2021
Location: Baltimore, MD
This technical position of Research Lab Technician is to perform sample preparation, matrix-assisted laser desorption/ionization (MALDI) imaging, and data analysis in the Applied Imaging Mass Spectrometry (AIMS) Core at The Johns Hopkins Medical Institutions (https://johnshopkins.corefacilities.org/service_center/show_external/3815). The candidate will closely work with and support the users of the AIMS Core under the supervision of the AIMS Core director. He/She is expected to section frozen or formalin-fixed paraffin-embedded (FFPE) tissues obtained from users onto conductive slides, use a robotic sprayer to spray enzymes/matrix onto tissue sections, set up MALDI imaging experiments, perform histology stains, and perform imaging data analysis under guidance. The candidate is expected to be knowledgeable about MALDI imaging analysis, SCiLS lab, iLAB, MATLAB, and statistical analysis methods. The candidate is expected to prepare reports about the obtained results in powerpoint and excel to be sent to users. The candidate is expected to frequently interact with AIMS Core users, requiring good people skills. The candidate is also expected to keep the AIMS Core facility clean, monitor inventory levels, order materials and supplies as needed, and keep records of all experiments performed in accordance with established policies and procedures.
Good people skills and good communication skills required. Exchanges information in an appropriate manner requiring good oral and written communication skills.
Education / Experience:
Required: B.Sc in chemistry or related field required. M.Sc. in chemistry or related field preferred. Preferred science courses with lab & research lab experience in analytical chemistry. Mass spectrometry, liquid chromatography mass spectrometry (LC-MS), high performance liquid chromatography (HPLC), MALDI mass spectrometry or MALDI imaging experience strongly preferred.
Background in analytical chemistry and mass spectrometry and HPLC required. Some related work experience preferred in a comparable lab performing MALDI mass spectrometry imaging, MALDI mass spectrometry, or other mass spectrometry imaging techniques, coupled with a general knowledge of biochemical/biological sciences or related field. Must be detail oriented, keep clear experimental records, have effective organizational skills, and be able to prioritize workload appropriately. Must be able to perform multiple tasks efficiently and correctly, often operating more than one instrument at a time. Experience in laboratory procedures and good computer skills required.
Any specific physical requirements for the job: Must be able to lift 25 lbs., must be able to sit for long period of time, and must be able to climb at least 4 flights of stairs.
Budget authority (indicate dollar amount of budget managed and type/level of authority): Will work in iLAB to approve billing of users. Will order supplies based on need in SAP.
Please email your application to Dr. Kristine Glunde at firstname.lastname@example.org
Posted: June 8, 2021
Location: College Park, MD
The Spectroscopy and Mass Spectrometry Branch of the U.S. Food and Drug Administration’s (FDA) Center for Food Safety and Applied Nutrition (CFSAN) in College Park, Maryland seeks a temporary researcher with a Doctoral degree to participate in our food safety research program. To support its mission, the FDA is developing and implementing non-targeted screening approaches using liquid chromatography/high-resolution mass spectrometry (LC/HR-MS) for food safety purposes. The selected candidate will assist in the development and evaluation of these methods to evaluate the chemical content of complex sample types. Candidates should have a Ph.D. degree in Chemistry, Food Science, Computer Science, or a related field. Desired experience includes LC/HR-MS data acquisition and processing, metabolomics, molecular networking, database/library curation, LC retention time prediction, semi-quantitation of unknowns, artificial intelligence/machine learning, and/or Compound Discoverer node development/programming ability. U.S. citizenship, permanent resident status, or a valid J1 Visa is required (F1 with OPT is acceptable until a J1 is obtained). Applicants must have been living in the United States for at least a total of 3 out of the past 5 years and pass a background check. The start date is negotiable. Salary is dependent upon experience. Duration: 1 year with possibility of renewal. Please email your CV to: Dr. Ann Knolhoff, email@example.com
Posted: June 3, 2021
Location: Rockville, MD
Within the Analytical Development US, Expert Scientist, Mass Spec and Spectrophotometry (Biophysical Characterization) will serve as Subject Matter Expert (SME) in LC-MS and biophysical analysis of vaccine antigens. The scientist will be responsible for characterizing antigens and their interactions using Mass Spec and an array of biophysical and traditional protein chemistry tools. The role is focused on providing a structure-function understanding to support assays development activities for all stages of vaccine development.
This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:
Independently select the design and execute of experiments based on interpretation of results
Implement and maintain a scientifically current, state-of-the-art laboratory environment
Take a leadership role for safety, regulatory and compliance within their department
Provide attention to data quality, integrity and archiving for own work and of others
Peer-review of others work
PhD or Master’s with specialization in Mass Spectrometry
6+ experience in industry/academic (pharmaceutical or biotech) setting working on characterizing diverse molecules (proteins, carbohydrates, nucleotides) by mass spectroscopy and spectrophotometry
Experience with analytical development for vaccine/ biotherapeutic
Experience in protein chemistry
Experience with qualitative and quantitative characterization of proteins and nucleotides using MS platform (Glycan profiling, peptide mapping, intact mass).
Strong laboratory skills
Familiarity with HDX for higher order structure determination, epitope / paratope mapping.
Knowledge and experience with Quality by Design, Process Analytical Technology, CMC, regulatory filling, and managing CMC program
Experience with, liquid handling systems, and robotic automation
Apply online: https://gsk.wd5.myworkdayjobs.com/GSKCareers/job/USA—Maryland—Rockville/Expert-Scientist_291158-1
Posted: June 3, 2021
Location: Rockville, MD
Within the Analytical Development US, the Scientist, PhysicoChemical Characterization will serve as Subject Matter Expert (SME) in state-of-the-art spectroscopy (Mass /Optical) and sizing technologies and its application to vaccine development. The Scientist will be responsible for the design, development of qualitative/quantitative spectroscopic methodologies and data analysis approaches. The role will support drug substance/drug product characterization, product and process development, the development and transfer of release methods for GMP testing.
This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following…
Will provide support and technical knowledge in dealing with regulatory filings specifically related to spectroscopy and product characterization.
Collaborates with other development functions (locally and globally) to meet project deliverable and timelines.
Lead the in evaluation and developability of Mass spectroscopy, Fluorescence, FTIR, Raman, CD, MALS, AUC, Calorimetry based assay development.
Serve as subject matter expert on new and existing mass spectroscopy and spectroscopy platforms.
Explore new materials, methods, instrumentation, and equipment
Plans, designs and execute the studies when assigned to the project.
Present results internally and externally at industry and scientific conferences.
Publish in top tier journals.
Follow GSK procedures and core values
MS (6+ years) experience in mass spectrometry, bio/analytical, biochemistry, pharmaceutical chemistry.
Experience with high resolution analysis of protein, carbohydrates, lipids, polynucleotides (DNA/RNA) and nanoparticle characterization.
Operating and maintaining state-of- the-art MS instruments including, but not limited to Thermo Orbitrap, Waters Xevo QTOF, AB
Experience in operating and maintain biophysical characterization instrumentation.
Ph.D. (0-3+ years) experience in mass spectrometry, bio/analytical, biochemistry, pharmaceutical chemistry.
A detail-oriented self-starter and be able to work independently under minimum supervision
Experience with, liquid handling systems, and robotic automation.
Hands-on experience with applying MS- based methodologies such as H/D exchange, chemical crosslinking, SILAC, MRM, top down/Bottom up, peptide mapping, PTM characterization, HCP profiling, glycan analysis, disulfide bond mapping.
Apply online: https://gsk.wd5.myworkdayjobs.com/GSKCareers/job/USA—Maryland—Rockville/Scientist–Physico-Chemical-Characterization_288128
Posted: April 7, 2021
Location: College Park, MD
The Spectroscopy and Mass Spectrometry Branch, Division of Analytical Chemistry, Office of Regulatory Science of the U.S. Food and Drug Administration’s Center for Food Safety and Applied Nutrition (CFSAN) seeks two postdoctoral fellows to participate in our food allergen research program. The primary research goals are the development and use of mass spectrometric techniques for the detection and quantification of food allergens. These research projects are components of agency-wide, on-going food safety and food defense programs, which support important FDA policy and regulatory decisions.
Candidates should have a Ph.D. degree in Analytical Chemistry, Biochemistry or a related field, and a strong background and interest in learning and gaining experience with the latest liquid chromatographic and mass spectrometric techniques, such as those for proteomics. Training or experience in food science and food analysis method development is desirable.
Please email your CV by COB 4/9/21:
Dr. Katherine Fiedler and Dr. Peter Scholl
US FDA/Center for Food Safety and Applied Nutrition
5001 Campus Drive
College Park, MD 20740
firstname.lastname@example.org and email@example.com
Posted: April 1, 2021
Location: New York, NY
GENERAL STATEMENT OF RESPONSIBILITIES & DUTIES:
This role provides scientific instrument and methodology support under the supervision of a Research Scientist.
Duties will include testing, implementing, and evaluating new sample preparation methodologies and mass
spectrometric (MS) analysis for the evaluation of protein-containing art related materials. Duties also include
the preparation and artificial ageing of replica samples; coordination of sample collection, distribution, and
analytical results from three institutions; perform and evaluate sample preparation methodologies by MS. This
9-month full time position ($24/hour plus benefits) is funded by the Richard F. Lounsbery Foundation and will
begin as soon as possible.
PRIMARY RESPONSIBILITIES & DUTIES:
• Assists in the evaluation of novel and established sample preparation methodologies for analysis of
cultural heritage using established advanced MS analytical techniques and protocols including but not
limited to proteins.
• Prepare samples according to established and/or new protocols for proteomics and other omics
• Accompany samples and either perform MS analysis or alternatively work with collaborators to perform
• Performs data analysis, optimizing protocols, statistical comparison of data sets, and exploring platforms
• Researches, plans, conducts, and documents, the creation of replica exemplar materials as well as
artificial ageing protocols, followed by characterization of the artificially aged material.
• Plans, conducts, and documents the collection and dissemination of replica and authentic samples to
• Manages and collects data from collaborating institutions.
• Performs literature reviews of scientific and conservation publications, proposing improvements to
existing protocols and procedures.
• Writes progress and summary reports, standard operating procedures, and annotated bibliographies on
related topics and activities.
• Develops platforms and activities for public engagement, as well as writes scientific articles, papers,
reports or books, as appropriate.
• Other duties as assigned
REQUIREMENTS & QUALIFICATIONS
Experience and Skills:
• Strong laboratory experience in organic, biological, or biochemical chemistry (preferred).
• Experience preparing protein or other materials for analysis by ELISA, LC/MS or MALDI (preferred).
• Experience operating and analyzing data from at least two analytical tools. Examples
include but are not limited to optical spectroscopy, Raman or IR spectroscopy, liquid or gas
chromatography, mass spectrometry, ELISA or MALDI (required).
• Familiar with statistical analysis of data (preferred).
• Previous museum experience (preferred).
• Proficient in Microsoft Word processing, Excel spreadsheet manipulation, and use of
PowerPoint for documenting, processing, and presenting information (required).
• Strong organizational skills (required).
• Strong command of both written and spoken English (required).
Knowledge and Education:
M.S. in chemistry, biochemistry, materials science, or biology, or BS with equivalent training and
Strong general chemistry and organic chemistry lab experience. (required)
Strong command of both written and spoken English. (required)
Please send cover letter, resume, and letters of two references to firstname.lastname@example.org with “Sr Research
Assistant/Scientific Research Department” in the subject line.
Location: The Met Fifth Avenue
Salary Grade: 16
Employee Classification: Full time non-exempt
End Date: 9 months from date of hire