Posted: June 3, 2020
Location: Silver Spring, MD
The Food and Drug Administration Center for Biologics Evaluation and Research is seeking a motivated post-doctoral individual to join The Division of Bacterial, Parasitic & Allergenic Products Laboratory of Bacterial Polysaccharides Vaccine Structure Group. The successful candidate will work with an experienced research team to investigate the structural aspects of glycoconjugate based vaccines.
The position will focus on mass spectrometry-based approaches for analysis of glycoproteins and other glycoconjugates particularly in the area of vaccine antigens. Glycan array technologies will also be implemented to study viral pathogen interactions with host glycoconjugate receptors. These studies will facilitate a better understanding of how glycosylation can impact on vaccine performance and how glycosylation impacts the host-pathogen interface.
This position requires a Ph. D. in chemistry, biochemistry, structural biology or a related science. New graduates are welcome to apply. A background in mass spectrometry is required. Experience in glycobiology, carbohydrate chemistry, proteomics mass spectrometry and/or glycan array is a plus. The laboratory’s research crosses the boundaries between analytical chemistry, structural biology, biochemistry and microbiology. The laboratory develops state of the art mass spectrometric and glycan array platforms for use in FDA mission critical projects centered in issues surrounding glycosylation of key vaccine antigens. Excellent communication skills (oral and written) and the ability to work in a team environment are required.
Salary will be commensurate with qualifications and experience. To be considered for this position, please write or email your Curriculum vitae to:
John F. Cipollo, Ph. D.
Center for Biologics Evaluation and Research
Division of Bacterial, Parasitic and Allergenic Products
Food and Drug Administration
10903 New Hampshire Avenue
Building # 52/72 and Room # G310
Silver Spring, MD 20993-0002
Posted: May 12, 2020
Location: Silver Spring, MD
A research opportunity is currently available in the Office of Vaccines Research and Review (OVRR), at the Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA) in Silver Spring, Maryland. This research opportunity will be within the Laboratory of Bacterial Polysaccharides with the goal of using recombinant technologies, metabolic engineering and/ synthetic biology as tools to improve the understanding of glycoconjugate vaccine synthesis and immunology. The selected participant will receive mentoring on fulfilling the project, which will also include collaboration with investigators within and external to the FDA. The participant will be studying Glycoengineered Outer Membrane Vesicles (geOMV) as an alternative platform to generate glycoconjugate vaccines that target encapsulated pathogens. The participant will generate a prototype expression system to reconstitute bacterial polysaccharides (e.g. capsule, O-antigen) in Escherichia coli, and test and evaluate the immune response of the purified geOMV. The position is available for a start date of September 1, 2020.
The qualified candidate should have received a Doctoral degree in biochemistry, molecular biology or related field. Degree must have been received within five years of the appointment start date. Applicants must have resided in the USA for 3 of the last 5 years.
• Biochemistry and molecular biology, such as designing and cloning plasmid constructs, bacterial and tissue cultural techniques, recombinant protein expression and purification, PAGE/Western blot protein analysis and performing respective functional / binding assays
• Knowledge of glycobiology and mass spectrometry
The following papers provide examples of the research project:
1. Haurat MF et al. Biol Chem. 2015. doi: 10.1515/hsz-2014-0183
2. Elhenawy, W. et al. MBio. 2016. 10.1128/mBio.00940-16
3. Price, N. L. et al. Sci Rep. 2016. doi: 10.1038/srep24931
How to apply: Interested applicants should send their curriculum vitae, statement of research interests, along with contact information for three references to Dr. M. Florencia Haurat, firstname.lastname@example.org
Posted: April 30, 2020
Location: Silver Spring, MD
The National Institute on Aging (NIA), a major research component of the National Institutes of Health (NIH) and Department of Health and Human Services (DHHS), is recruiting for a Staff Scientist/Facility Head in the Laboratory of Clinical Investigation (LCI) to oversee proteomic requirements within the NIA Intramural Research Program (IRP), located in Baltimore, MD. The Laboratory/Branches within the NIA IRP carry out basic and clinical biological research with an emphasis on aging phenotypes. The incumbent will report directly to the Laboratory Chief.
The individual must have a Ph.D. (or equivalent doctoral degree) in Analytical Chemistry or related fields, with significant experience in analytical chemistry. Applicants must have strong documentation of prior research experience and skills. The incumbent will be expected to work independently, but also form collaborations with multiple NIA laboratories. The individual will have the opportunity for significant interactions and collaborations with Investigators, Staff Scientists, and Staff Clinicians at the NIA to provide guidance for projects including providing input to clinical scientists/physicians working in human subjects. In the laboratory, the incumbent will carry out mass spectrometry-based analysis of cell culture and in vivo-derived protein samples to quantify known peptides and identify novel proteins and biomarkers. Candidates must have experience with all aspects of mass spectrometry analysis including sample preparation, peptide separation methods, AQUA peptide-based quantification, and data analysis and interpretation. Specific experience with Thermo Scientific Orbitrap-based mass spectrometry systems and analysis is essential. Additional experience with discovery-based proteomics will be considered favorably.
Salary is commensurate with research experience and accomplishments. A full Civil Service package of benefits (including retirement, health, life, and long-term care insurance, Thrift Savings Plan participation, etc.) is available. All employees of the Federal Government are subject to the conflict of interest statutes and regulations, including the Standards of Ethical Conduct. Additional information regarding the NIA IRP is available at the following website: www.irp.nia.nih.gov.
To apply: Please send a cover letter, curriculum vitae, bibliography, statement of research interests, and three letters of recommendation to: Angela Prazak, Intramural Program Specialist; Office of the Scientific Director; Vacancy #NIA-IRP-20-14; National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Room 04C230, Baltimore, MD 21224 or email: email@example.com. Applications, including letters of recommendation, must reference Vacancy #NIA-IRP-20-14 for consideration. The first round of reviews is expected to occur on or about May 29, 2020; however, applications will be accepted until the position is filled.
Posted: April 27-May 22, 2020
Location: Greenbelt, MD
The Planetary Environments Lab (PEL) at NASA’s Goddard Space Flight Center in Greenbelt, MD is seeking an instrument scientist, with an emphasis on mass spectrometry, for a civil servant position opening. The candidate must have expertise in a variety of mass spectrometry techniques, with experience in the development, testing, and implementation of current and next generation mass spectrometer techniques. The PEL has developed mass spectrometers and sampling systems for a variety of planetary missions, including: Sample Analysis at Mars (SAM) on the Curiosity rover, MOMA on the ExoMars rover, MAVEN NGIMS, Cassini-Huygens GCMS, Cassini INMS, LADEE NMS, and is presently developing mass spectrometers for lunar missions and the mass spectrometer on the Dragonfly mission to Titan.
For more information on the NASA Goddard Space Flight Center’s Planetary Environment Lab, please visit:
NASA recognizes that candidates with non-traditional career paths, or individuals who are at earlier stages of their careers may have demonstrated experience in different ways. NASA encourages applications from such individuals.
Please note that this is a fair and open competition that all U.S. Citizens and Status candidates can apply to.
A full vacancy announcement, which contains further information including qualification requirements and application instructions, will be posted to https://www.usajobs.gov/ on May 18, and remain open for Five (5) days. The short period that the announcement is open is due to the type of hiring authority, which streamlines the hiring process and assists with rapidly filling competitive positions. It is not a reflection of the openness of the position. Advance notice of the vacancy is being provided to allow interested scientists to prepare. In order to apply for this position, you will only need to submit your resume and answer the screening questions and supplemental information through USAJOBS.
Given the short period the announcement will be open, it is a good idea to log into USAJOBS before and update your username, password, resume, etc., to facilitate the timely submission of an application. Candidates interested in being notified when this job opportunity is posted on USAJOBS and opened for five days are encouraged to sign up for a notification using the features of the USAJOBS website.
Candidates interested in this opportunity are encouraged to contact NASA well in advance so they can make a well informed decision on submitting an application during the very short (5 day) window when the job opportunity will be open for applications. Questions about this anticipated opening may be directed to the Chief of the Planetary Environments Lab: Charles Malespin, firstname.lastname@example.org.
Posted: April 21, 2020
Location: College Park, MD
A research opportunity is currently available at the U.S. Food and Drug Administration (FDA), Center for Food Safety and Applied Nutrition (CFSAN), Office of Regulatory Science (ORS) located in College Park, Maryland.
This project will be to help develop methods to screen for contaminants in food and packaging. Under the guidance of a mentor, the selected participant will receive training in and will focus on: the mass spectrometry of food packaging and contaminants, in particular ambient ionization, non-targeted analysis, suspect screening, database development, and metal ionization and gas phase chemistry. Research activities will include: sample preparation, mass spectrometric method development and analysis, database creation/curation, method comparison, method validation, and experimental mechanism investigation. The goal is to develop rapid food packaging material identification and contaminant screening methods.
Anticipated Appointment Start Date: as soon as a qualified candidate is identified
This program, administered by ORAU through its contract with the U.S. Department of Energy to manage the Oak Ridge Institute for Science and Education, was established through an interagency agreement between DOE and FDA. The initial appointment is for one year, but may be renewed upon recommendation of FDA contingent on the availability of funds. The participant will receive a monthly stipend commensurate with educational level and experience. Proof of health insurance is required for participation in this program. The appointment is full-time at FDA in the College Park, Maryland, area. Participants do not become employees of FDA, DOE or the program administrator, and there are no employment-related benefits.
Completion of a successful background investigation by the Office of Personnel Management is required for an applicant to be on-boarded at FDA. OPM can complete a background investigation only for individuals, including non-US Citizens, who have resided in the US for a total of three of the past five years.
FDA requires ORISE participants to read and sign their FDA Education and Training Agreement within 30 days of his/her start date, setting forth the conditions and expectations for his/her educational appointment at the agency. This agreement covers such topics as the following:
Non-employee nature of the ORISE appointment;
Prohibition on ORISE Fellows performing inherently governmental functions;
Obligation of ORISE Fellows to convey all necessary rights to the FDA regarding intellectual property conceived or first reduced to practice during their fellowship;
The fact that research materials and laboratory notebooks are the property of the FDA;
ORISE fellow’s obligation to protect and not to further disclose or use non-public information.
The qualified candidate should be currently pursuing or have received a master’s or doctoral degree in one of the relevant fields. Degree must have been received within five years of the appointment start date.
Experience performing non/semi-targeted analysis
Experience developing analytical methods
Experience in planning and executing statistically complex studies utilizing ambient ionization and/or mass spectrometry
Ability to effectively communicate both verbally and in writing
Degree: Master’s Degree or Doctoral Degree received within the last 60 months or currently pursuing.
Earth and Geosciences
Life Health and Medical Sciences
Mathematics and Statistics
Other Physical Sciences
Apply at https://www.zintellect.com/Opportunity/Details/FDA-CFSAN-2020-0008
Posted: March 2, 2020
Location: Gaithursburg, MD
The territory account manager is responsible for selling chromatography and laboratory consumable products for the Chromatography Consumables business within the Analytical Instruments Group. This person will focus on exceeding sales quotas for the full product portfolio within the assigned territory by selling and negotiating contracts to close orders with end user customers, key decision makers and procurement. Must be able to collaborate with tele-sales reps, channel distribution partners, product & application specialists, chromatography & mass spectrometry instrument teams, customer experience and business development teams as well as other inter-company synergistic individuals.
Territory: This field based position covers the MD, DE, DC and the northern Virginia area and will require overnight travel at times up to 30%
What will you do?
Achieve/ exceed assigned monthly & yearly sales goals/quotas within assigned territory
Identify, develop and close large sales opportunities
Develop and implement strategic account specific strategies to develop new customers and opportunities and secure territorial annual sales growth consistent with corporate/divisional AOP goals
Ability to use sales tools, develop detailed business plans, organize, accurately forecast territory results, provide market intelligence, implement value selling and meet sales objections while operating within expense budgets and control costs
Sells new products by establishing key customers relationships and understanding customer application needs
Aligns with applicable channel/distribution partners, tele-sales reps, channel distribution partners, product & application specialists, chromatography & mass spectrometry instruments, customer experience and business development teams
Lead Key Account activities for high value accounts. Possibly cross-territories
Maintain and continue to develop a superior knowledge of our products and their applications.
Train and motivate channel/distribution/rep organizations to optimize achievement of sales goals via their supplementary efforts.
Monitor competitive activity and industry trends, fosters competitive solutions to meet sales goals
Timely submit forecasts, weekly reports, monthly highlights, marketing intelligence, and other related reports for defined territory to supervisor
Maintain accurate and current records of proposals, opportunities, accounts, contacts, leads and actions through SalesForce.com CRM within defined territory
Keep manager abreast of any new developments in the marketplace (competitive, product, customer, wins/losses, etc…)
Present the company’s products in a positive manner and maintain/build our reputation in the marketplace
Maintain intensity persistence and continually strive to increase market share
Education and Required Experience:
BS degree in Chemistry or related field required
Minimum two years of selling experience strongly preferred.
Must have working knowledge of Chromatography (GC and HPLC) and should have knowledge of Mass Spectrometry (GC/MS and LC/MS).
Must also have a broad familiarity with the following industries: pharmaceutical, academia research, medical research, environmental, food/flavors, clinical/toxicology, forensics, biotech and petrochemical/petroleum.
Experience developing and executing sales and/or field marketing plans as well as time/territory management plans to develop long-term relationships, drive account expansion and penetration.
Knowledgeable with respect to competitive landscape for chromatography products and services.
Ability to identify new target accounts each year and be able to develop and execute territory plans.
Prior experience forecasting and use of a CRM (SFDC) for reporting.
Experience in managing independent selling or distribution channels a definite plus.
This position has not been approved for relocation assistance.
Apply online at https://jobs.thermofisher.com/global/en/job/114458BR/Account-Manager-Chromatography-Consumables
Posted: February 27, 2020
Location: Silver Spring, MD
The Office of Science and Engineering Laboratories (OSEL) is the laboratory at the Center for Devices and Radiological Health (CDRH) of the Food and Drug Administration. OSEL performs product testing; develops reliable standardized test methods for CDRH and industry use; performs anticipatory scientific investigations on emerging technologies; contributes laboratory data to national and international standards used in CDRH decision making; provides scientific and technical training for CDRH staff members; and maintains laboratory collaborations and relationships with scientific researchers in academia and other Federal laboratories. OSEL also coordinates and oversees CDRH’s activities that support the development of national and international standards.
Position Information: This appointment is offered through the CDRH Postgraduate Research Participation Program and is administered by the Oak Ridge Institute for Science and Education (ORISE). The program is open to all qualified U.S. and non-U.S citizens (EAD, OPT or CPT is required. An H1 or J1 visa cannot be sponsored for this position) without regard to race, color, age religion, sex, national origin, physical or mental disability, or status as a Vietnam-era veteran or disabled veteran. The individual selected for appointments will not become employees of ORISE, ORAU, DOE, FDA, CDRH, or any other office or agency. Program participants will be paid a monthly stipend. Note this is not a GS position. This is an educational program and candidates should be within 5 years after Ph.D. completion.
Duties: The fellow will perform studies related to analysis of extractable and leachable chemicals from materials used in medical devices. Tasks will include method development and validation for extraction, identification, quantification of substances contained in polymeric and other materials to support CDRH’s regulatory mission.
• Applicant must have received a PhD in analytical chemistry or a related field such as chemistry or chemical engineering within last five years
• Hands-on experience in following techniques including but not limited to: liquid chromatography mass spectrometry (LC/MS- preferably Q exactive, Q TOF and/or QQQ), gas chromatography mass spectrometry (GC/MS), and inductively coupled plasma mass spectrometry (ICP/MS)
• Experience in quantification of small molecules and polymers
• Experience in data analysis software packages, spectral library matching, database generation and statistical evaluation
• An understanding of extractables and leachables studies
• Good writing and communication skills
How to Apply: Qualified applicants may send their cover letter, resume or CV, and contact information of three professional references to Samanthi.Wickramasekara@fda.hhs.gov. This is not a career-conditional competitive position.
Posted: February 18, 2020
Location: Chapel Hill, NC
Position Type Permanent Staff: (EHRA NF)
Department: Envir Sciences and Engineering-463001
Appointment Type: EHRA Non-Faculty Research
Position Posting Category: Research Professionals
Salary Range: Dependent on Qualifications
Full Time/Part Time?: Full-Time Permanent
Hours per Week: 40
Posting Open Date: 02/11/2020
Application Deadline: 03/12/2020
Open Until Filled: No
Proposed Start Date: 05/01/2020
The Biomarker Mass Spectrometry Facility provides critical analytical support to UNC researchers for qualitative and quantitative assessment of environmental contaminants and biomarkers using mass spectrometry. The Facility houses an AB Sciex 6500 mass spectrometer, Thermo TSQ mass spectrometers, Agilent Q-TOF, Agilent 7500 ICP-MS, and UPLC/nano-LC systems. Areas of focus for the Facility include characterization of chemical reaction products, identification and quantitation of metabolites, quantitation of environmental chemicals, measurement of DNA adducts, multi-element analysis and arsenic speciation in numerous environmental and biological matrices. The Biomarker Mass Spectrometry (MS) Research Scientist provides leadership and direction in the management of research and experiential learning activities that involve the MS laboratory. He/she supports the instructional and research mission of the Department through faculty and student engagement by providing support, consultation and expertise in analytical chemistry involving mass spectrometry. This includes method development, quality assurance, data analysis, student training, and instrument maintenance. Major responsibilities will include managing the operation of the Biomarker Mass Spectrometry Recharge Facility; developing analytical methods to support research, maintaining and upgrading the mass spectrometry and other instrument, training the users on instrumentation and sample analysis; providing expertise in method development and sample analysis; collaborating with researchers within and outside of ESE to support grant applications and research projects. The successful candidate will have strong background and demonstrated expertise in mass spectrometry and method development to support research activities of the Department. The incumbent will also contribute to the department’s educational goals by providing practical training in research skills and will have the opportunity to assist in developing laboratory courses.
Required: Relevant post-Baccalaureate degree required; for candidates demonstrating comparable independent research productivity, will accept a relevant undergraduate degree and 3 or more years of relevant experience in substitution.
Preferred: Ph.D. in analytical Chemistry, or MS with 5 years of experience or related field from appropriately accredited institutions.
Three or more years’ experience in mass spectrometry or relevant research experience.
Demonstrated experience in operating and maintaining modern mass spectrometers, preparing and loading samples, software and data analysis.
Expertise in operating and maintaining a range of mass spectrometry platforms, such as LC-MS and ICP-MS.
Demonstrated expertise in method development for the detection and quantitation of compounds in diverse environmental and biological samples.
Experience in training students and other users in method development and sample analysis.
Excellent written and oral communication skills are needed.
Experience with mass spectrometry of AB Sciex, Agilent and Thermo.
Capacity and strong motivation for learning new technical skills independently
Outstanding communication skills.
Experience and strong interest in training and working with students and postdoctoral trainees.
Experience in writing grant proposals and manuscripts.
Please indicate in your cover letter how you might contribute to an inclusive climate at Gillings. Apply at https://unc.peopleadmin.com/postings/176985
Posted: February 10, 2020
Location: Sykesville, MD
Zeteo Tech, Inc, a venture backed company developing solution for Medical and Biodefense applications, is seeking a motivated chemist to join our team. The ideal candidate should be interested in working in an entrepreneurial environment developing game changing solutions to healthcare and national security challenges. You will use your expertise to conduct chemical and physical laboratory tests to assist scientists in development of tools to detect and identify biological organisms and materials.
Conduct chemical experiments, tests, and analyses using techniques such as MALDI-TOF mass spectrometry, gas chromatography mass spectrometry, and microscopy
Conduct chemical and physical laboratory tests to assist scientists in refining MALDI-TOF MS equipment
Compile and interpret results of tests and analyses
Provide technical support and assistance to our team of biologists, chemists, and engineers
Prepare chemical solutions for products and processes following standardized formulas, or create experimental formulas
Maintain, clean, and sterilize laboratory instruments and equipment
Write technical reports or prepare graphs and charts to document experimental results
Bachelor’s degree, chemistry preferred
1 – 5 years of working experience in the field
Knowledge of and experience with wet bench chemistry procedures
Ability to analyze data and accurately document and record results
Attention to detail and problem-solving skills
Ability to be a team player
Eligibility requirements include U.S. citizenship or permanent resident
What we can offer you in compensation:
Comprehensive medical and dental insurance, with 100% premiums paid for employees
401k plan with company match
Equity position in Zeteo Tech
Paid vacation, sick time, and holidays
Laptop for work use
Experience in a venture backed startup
Apply online at https://zeteotech.com/careers/
Posted: February 7, 2020
Location: Columbia, MD
Shimadzu Scientific Instruments is hiring a Product Specialist within our LCMS Product department to provide support to clients and field based employees for our rapidly growing LCMS product line. This is a great opportunity for someone with hands-on experience with these instruments to work in a customer facing setting who would like to advance their career! The employee will be supporting our entire United States sales territory and work in a small, closely knit team. Details are as follows:
The individual in this position is responsible for a wide variety of LCMS support related functions including, but not limited to, development of technical documents related to marketing, sales, application use, training, repair, maintenance, installation, and phone support of Shimadzu LCMS product line. Travel and customer contact to support assigned product may be required. Additional responsibilities include training customers and SSI staff, as well as, other related duties that may be assigned from time to time.
a. Providing support to sales staff for LCMS products from a marketing perspective.
b. Develop demonstration strategies and presentation of LCMS products to potential and current customers to support the sales effort.
c. Obtain and maintain competitive information for LCMS products and analyze for report to sales.
d. Assist in the creation of documentation for sales support materials including feature/benefit analysis and positioning strategies for LCMS products.
e. Evaluate and recommend market needs and then propose to develop and implement hardware and software resolutions to meet these needs.
f. Support qualification tests for large corporate customers and round robin tests with ASTM and other official organizations.
g. Support instrument quality procedures in house and in the field.
h. Perform applications work as required effectively positioning the LCMS products, and analyzing customer samples. Perform methodology adaptation work for customers as needed.
i. To produce customer support materials to further sales for the LCMS product line (such as brochures, technical notes, application notes flyers, etc…)
j. Operate as the company’s authority on the LCMS products, market position, and competitive strategy under the area of responsibility.
k. The application, operational and maintenance support of those products sold by SSI or its representatives.
l. Develop and provide technical training courses and materials for customers and SSI employees.
m. Develop a knowledge base through the accurate documentation and reporting of product failures and repairs.
n. Provide product design change and improvement recommendations.
o. Assist in the development of installation and maintenance procedures for products as required.
p. Maintain the current IQ/OQ/PT protocols and develops protocols for new products.
q. Maintain assigned instruments in application laboratories.
r. Travel as required, in order to effectively provide technical support the LCMS product line.
This position’s primary focus is to provide technical marketing materials and education to efficiently support product positioning of the LCMS products, as well as, provide timely and efficient support, of high quality, to our customers. This will include the full scope from product design to customer satisfaction, coordinating efforts with the Marketing team, Sales, Service, and the Regional staff.
Knowledge Requirements / Education / Experience:
The incumbent must be proficient at effectively troubleshooting operational, application and other LCMS instrument problems in a methodical efficient manner. Additionally, the incumbent must be able to act independently in matters not governed by policy to ensure customer satisfaction.
Education and/or Experience:
The incumbent is required to have at least a Bachelor’s degree in the life sciences, with a higher level degree highly preferred. At least two years of technical applications/method development experience directly related to the LCMS product line is required. Experience in maintenance and/or repair of analytical instrumentation, marketing background and any sales experience is highly desirable. Attention to detail and strong customer service skills are required along with a dependable work ethic.
Yes. Overnight Travel Required
Bachelors or better in Chemistry or related field.
Masters or better in Chemistry or related field.
PHD or better in Chemistry.
2 years: LCMS
Apply online at https://recruiting.ultipro.com/SHI1000/JobBoard/2bc2a753-1232-400c-84cf-ef90d5762b76/OpportunityDetail?opportunityId=cf00f0d7-9566-4e20-aef2-2c4d099e3ef9
Posted: February 6, 2020
Location: Gaithersburg, MD
Posting still open!
About the role
You will work in the laboratory as member of the expanding Dynamic Omics group and be actively involved in developing and implementing pipelines for metabolomics and proteomics applications to support the analysis of clinical samples. This position will be primarily focused on utilizing state-of-the-art proteomics and metabolomics technologies to investigate a number of biological questions in support of our clinical research and requires comprehensive expertise and hands-on experience in these areas. You must be passionate and enthusiastic about clinical and translational research and poses an in-depth understanding and hands-on experience with modern mass spectrometry and chromatography techniques. You will be responsible for establishing standardized methods and procedures for sample handling, processing and analysis as well as troubleshooting mass spectrometry instrumentation and automated platforms. A primary responsibility will be the operation of advanced nanoflow liquid chromatography and mass spectrometry (LC-MS) instrumentation (Fusion, Q-Exactive HF-X, Orbitrap ID-X, Agilent IMS-QTOF, TIMS-TOF, QTRAP) to support innovative proteomics and metabolomics profiling and translational research across our therapeutic areas, which include cardiovascular, renal, metabolic and respiratory diseases.
In addition to developing and maintaining technological capabilities, this role will involve planning and conducting laboratory experiments and interpreting complex proteomic and metabolomic data. Additionally, this position will closely collaborate with scientists in the Proteomics and Metabolomics, Flow Cytometry and Imaging groups and support Translational Scientists to set and implement biomarker strategies. Give the scope of this dynamic role and the need to multitask, it is essential to be a fast learner, excellent communicator, well organized, innovative and able to work independently when designing and executing experiments as well as to manage and prioritize tasks. Furthermore, you should demonstrate enthusiasm, motivation, attention to detail and willingness to learn new technologies, flexibility and confidence.
Ph.D. in Proteomics, Mass Spectrometry, Analytical Chemistry, Biochemistry or related field
Sci I: 3-6 years of post-doctoral experience in a relevant research area; without prior supervisory responsibility
The position is a hands-on, laboratory-based position
Experience with processing and analysis of biological matrices (urine, serum, plasma, fluids, tissue)
The candidate should be familiar with the entire proteomics and metabolomics pipeline (including sample preparation, LC and MS operation, data analysis) and able to conduct independent and innovative research
Experience with specific instruments (Fusion, Q-Exactive HF-X, Orbitrap ID-X, Agilent IMS-QTOF, TIMS-TOF, QTRAP) is preferred
Proficiency with MS data analysis software (MaxQuant etc.), bioinformatics and statistics tools
Strong written and oral communication skills
Proven ability to publish in peer-reviewed journals, generate technical report summaries and SOPs
Able to work well collaboratively in a team environment
Hands-on experience with method validation and QC implementation for proteomics and metabolomics workflows
Experience with handling, processing and analysis of diverse clinical specimens
Knowledge and working experience with automation/liquid handler platforms
Ability to collaborate across multiple disciplines
Apply online at https://astrazeneca.wd3.myworkdayjobs.com/Careers/job/US—Gaithersburg—MD/Scientist-I_R-062765
Posted: January 21, 2020
Location: Newark, DE
This senior staff member is accountable for the day to day management of (1) the laboratory coordination team(staff of 5) whose primary function is to support the scientific teams in our LCMSMS bioanalytical lab, and (2) the technical specialists engaged in the preventive and corrective maintenance of laboratory equipment at QPS, as well as (3) supporting QPS sites world-wide. This position requires international travel.
• Act as scientific advisor for the company on lab equipment related topics.
• Be a thought-leader in the area of expertise
• Provide leadership, direction and guidance in technical processes and procedures. Manage staff activities and priorities to minimize equipment downtime.
• Develop goals and priorities in conjunction with employees, and assign tasks and projects. Develop staff skills and training plans. Counsel, train, and coach subordinate staff. Implement corrective actions and conduct performance evaluations
• Review recurring technical issues, and recommend solutions; provide insight and technical strategy for planning of equipment upgrades.
• Ensure that preventive and corrective maintenance program meets SOP goals and regulatory standards, including Federal Drug Administration (FDA) regulations.
• Manage special projects as required; research scope of project, assign resources, and monitor progress of assigned staff
• Oversee the installation and repair of the LC/MS/MS and other associated analytical equipment from multiple vendors at QPS-DE facilities, and QPS subsidiaries as assigned.
• Direct or assist staff in troubleshooting LC/MS/MS problems by means of sophisticated diagnostic instrumentation processes.
• Responsible for planned preventative maintenance, calibration and regular maintenance of the LC/MS/MS and other associated analytical equipment at all QPS-DE facilities, and QPS subsidiaries as assigned..
• Responsible for determining cost saving initiatives for supplies and repairs of lab equipment.
• Oversee the implementation of new technology for bioanalytical operations.
• Provide continuous training and development of scientific staff.
• Compile and analyze data. Prepare and process special and recurring reports and administrative records. Review and analyze service records
• Develop and monitor budgets and contracts. Review and evaluate equipment purchases, parts inventory and usage trends, and recommend procurement strategies.
• Limited international travel to Taiwan and China.
• Conceptual and analytical thinking
• Interpersonal awareness and concern for impact
• Concern for standards
• Results orientation
• Development orientation
Knowledge / Skills / Abilities
• Mastery of instrumentation techniques, practices and theories.
• Expertise with the electronics and optics of LC/MS/MS and other analytical equipment.
• Knowledge of LCMSMS lab equipment l electronics, equipment hardware and software systems and communications devices.
• Knowledge of LCMSMS electronic equipment functions, repair procedures, codes and standards.
• Knowledge of safety policies and procedures, and OSHA rules and regulations.
• Demonstrated ability to effectively manage staff, and delegate tasks and authority.
• Demonstrated ability to assess and prioritize multiple tasks, projects and demands.
• Demonstrated ability to establish and maintain effective working relations with co-workers, contractors, and staff.
• Proven technical troubleshooting skills
Education / Experience
• BS/MS in Electrical Engineering, Biochemistry or related science
• 5-10 years of experience in the manufacture, installation and/or maintenance of analytical equipment
FOR MORE INFORMATION PLEASE CONTACT:
• Cym Wasserman (203)255-4698