Available Positions

Johns Hopkins Analytical Pharmacology Core: Research Laboratory Technician (3/3/21)

Georgetown University: Post-Doc Fellow/PhD-level Research Specialist I in Proteomics (3/1/21)

US Pharmacopeia: Scientist II/III, Analytical Development Laboratory (2/5/21)

Univ. Maryland: Postdoctoral Associate (Ultrasensitive Proteomics) (2/4/21)

Univ. Maryland: Postdoctoral Associate (Ultrasensitive Metabolomics) (2/4/21)

Interfolio: Post-doctoral Research Associate (Microbiology) (1/27/21)

EMAST: Instrument Technician (1/19/21)

EMAST: Research Scientist (1/8/21)

Johns Hopkins: Core Research Laboratory Technologist (12/7/20)

NIH: Postdoctoral Fellow (12/4/20)

FDA CBER: Postdoctoral Fellow (10/21/20)

USDA: Postdoctoral Associate (10/20/20)

Bruker: Field Sales Representative (10/6/20)

Medical Science & Computing: Proteomics Scientist (9/18/20)

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Johns Hopkins Analytical Pharmacology Core: Research Laboratory Technician

Posted: March 3, 2021
Location: Baltimore, MD

This technical position of Research Lab Technician is located in the Analytical Pharmacology Core Laboratory, which is part of the Johns Hopkins School of Medicine Oncology Department. The Core’s main focus is to determine drug/metabolite concentrations in blood and tissue from preclinical experiments or clinical trials. The Research Lab Technician will be responsible for performing analytical methods for drug analysis, among other duties. These additional duties include operation of basic equipment (e.g., centrifuge, pH meter, balance). The technician will also operate the UPLC/MS/MS to complete sample analysis in various matrices and species, and will develop methods depending on his/her level of experience. Sample preparation will be an important part of this position, with the most commonly used techniques being protein precipitation, liquid-liquid extraction, and SPE. Along with sample preparation, the technician will be responsible for preparing reagents for experiments. The candidate will need to abide by GLP guidelines and lab SOPs, comply with extensive documentation in lab notebooks. The technician will be expected to adhere to biohazard/radiation safety standards and must follow universal safety precautions for blood-borne pathogens. Further duties include assisting with the evaluation of incoming study samples, utilization of the lab database, attending regular safety trainings, monitoring inventory levels, creating SOPs, and contributing to peer-reviewed manuscripts and grants. This position will also allow the technician to perform entry-level pharmacokinetic analysis under supervision. Bachelor’s degree in biology, chemistry or related field required.

To apply to this position, please email Ms. Nicole Anders at nander16@jhmi.edu.
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Georgetown University: Post-Doc Fellow/PhD-level Research Specialist I in Proteomics

Posted: March 1, 2021
Location: Washington, DC

Georgetown University School of Medicine is seeking a Post-Doc Fellow or PhD level Research Specialist I to perform proteomics services and apply cutting-edge proteomic techniques for basic and translational biomedical research. The candidate will work in a proteomics core lab, Georgetown University Medical Center. The candidate is expected to help maintain the state-of-the-art mass spectrometry instruments and play a key role in strengthening the method development for protein/peptide analysis, especially on PTM-omics (including glycoproteomics). The candidate will have plenty of opportunities to collaborate with scientists of very diverse background (including physicians) on campus, neighbor institutions (including NIH/FDA) and pharmaceutical companies in the Washington DC metropolitan area.

Key Responsibilities:
1. Operate, maintain, and troubleshoot advanced nanoUHPLC-MS/MS platforms
2. Develop analytical methods for the qualitative and quantitative proteomics/peptidomics

Requirements:
1. Strong hands-on skills handling high resolution mass spectrometers from Thermo (e.g., Orbitrap Lumos) and Sciex (e.g., TripleTOF 5600/6600, Q-TRAP 6500)
2. Extensive hands-on experience in proteomic workflows (including sample prep., data acquisition, and
data analysis), especially for PTM-omics
3. Enriched experience with isotopic labeling and label-free proteomic quantification methods
4. Familiar with software and bioinformatic tools for proteomic data analysis
5. Good communication and English-writing skills
6. Highly motivated and self-driven with the flexibility to quickly adapt to different projects
7. Willing to supervise and train students and fellows

To those who are interested, please send a cover letter and your CV with contact information of 3 references to Dr. Junfeng Ma (jm3004@georgetown.edu). In the cover letter, please briefly describe your research experience, career plan, earliest starting date, and etc. The position is open immediately and we anticipate filling the position as soon as possible. Competitive salary and benefits can be provided to the candidate depends on experience level. Georgetown University offers an impressive benefits package (including an annual 403b retirement contribution and comprehensive individual/family healthcare plans).
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US Pharmacopeia: Scientist II/III, Analytical Development Laboratory

Posted: February 5, 2021
Location: Rockville, MD

This is a non-supervisory, technical position in USP’s Compendial Development Laboratory (CDL). In this role, the Scientist II/III is responsible for working on technical problems in analytical chemistry related to the development and validation of specific methods that directly support monograph creation/revisions to the various USP compendia. This work includes development and/or validation of analytical procedures supporting the identity, strength, and purity of drug substances, drug products, dietary supplements, or excipients. The Scientist II/III has a broad range of experience in various analytical techniques in the laboratory and can troubleshoot, possibly lead, and provide input on difficult projects, while drawing independent conclusions about the results. He or she will make advances in science, processes, and internal capability that result in new or improved scientific expertise in the laboratory. The Scientist II/III may execute 75%-100% of their work at the bench level.

Roles and Responsibilities
Works independently to develop and validate methodologies for the analysis of drug substances, drug products, dietary substances, and excipients;
Demonstrates solid scientific approach to analysis in the laboratory;
Routinely applies personal experience, academic training, and technical insights to solve technical problems;
Conducts method development and validation of analytical procedures according to USP and international standards;
Perform all experimental activities and provide input on / draw conclusions required to evaluate proposed compendial procedures and reference materials;
Records experimental data, ensuring clear and accurate transcription of results and calculations;
Assists and / or conducts planning of experiments required for all projects, as well as interprets and evaluates data;
Energetically participates and coordinates activities with laboratory teams and internal customers to execute technical tasks and communicate results of work;
Executes all testing and analysis of data with excellence and essentially no errors;
May decide on the utilization of results or changes in project direction;
Demonstrates a strong desire to continue learning and grow personal capability;
Participates and / or presents at internal and external scientific meetings;
May train less experienced staff in various aspects of ADL work/processes/instrumentation;
Pursues, recommends, and implements new approaches or processes to improve laboratory operations;
Troubleshoots lab problems independently or with minimal assistance
Positively influences project direction by ensuring work is congruent with overall direction of the customer and laboratory team

Basic Qualifications
Scientist II
Bachelor’s degree in a scientific discipline with four years of relevant experience. In limited circumstances, an equivalent combination of training or special scientific accomplishments is acceptable in lieu of the years of relevant experience.
OR
Master’s degree in a scientific discipline with two years of relevant experience. In limited circumstances, an equivalent combination of training or special scientific accomplishments is acceptable in lieu of the years of relevant experience.
AND
Working knowledge, understanding, and hands-on experience with separation analyses such as liquid (HPLC, UPLC) and gas chromatography (GC), as well as other general analytical chemistry principles and techniques.

Scientist III
Bachelor’s degree in a scientific discipline with seven years of relevant experience. In limited circumstances, an equivalent combination of training or special scientific accomplishments is acceptable in lieu of the years of relevant experience.
OR
Master’s degree in a scientific discipline with five years of relevant experience. In limited circumstances, an equivalent combination of training or special scientific accomplishments is acceptable in lieu of the years of relevant experience.
OR
PhD. degree in a scientific discipline.
AND
Working knowledge, understanding, and hands-on experience with separation analyses such as liquid (HPLC, UPLC) and gas chromatography (GC), as well as other general analytical chemistry principles and techniques.

Preferred Qualifications
Knowledge of small molecule/natural product analysis by NMR (especially qNMR), LC/MS and/or GC/MS a plus.
Experience with quantitative LC/MS/MS and/or GC/MS/MS a plus.
Must have excellent project organization skills and the capability to plan and conduct research independently.
Possesses the skills to anticipate, troubleshoot, and solve technical problems.
Highly motivated individual with excellent technical writing and excellent oral communication skills.
Well-developed interpersonal, negotiation, and listening skills.
Must possess the ability to multi-task and to work effectively with a team
Takes personal responsibility to ensure work is delivered on time and is of the highest possible quality.
Experience working in the compendial, pharmaceutical and/or biotechnology industry strongly preferred.
Experience working with Empower chromatography software is a plus.

USP offers an impressive benefits package, including:
Generous paid time off – 15 paid holidays, 10 sick days and 15 vacation days per year to start
An annual 401(k) contribution, beginning after 1 year of service, of 10% of pay (base and bonus) every pay period that vests immediately
Comprehensive individual and family healthcare plans with affordable premiums and low annual deductibles.

Apply online at https://usp.jobs/rockville-md/scientist-iiiii-analytical-development-laboratory/D78D832891A64B788D49AF02D0D2019C/job/
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Univ. Maryland: Postdoctoral Associate (Ultrasensitive Proteomics)

Posted: February 4, 2021
Location: College Park, MD

The Nemes Research Laboratory (NRG) has pioneered ultrasensitive proteomics for cell and developmental biology and neuroscience and has discovered molecules capable of altering normal cell fate decisions (see group website: http://blog.umd.edu/nemes/). The NRG is hereby seeking a talented and motivated postdoctoral researcher with existing experience in bottom-up proteomic workflows of sample preparation, nano-flow liquid chromatography, orbitrap mass spectrometry, multiplexing quantification (e.g., TMT, iTRAQ), and bioinformatics (e.g., SEQUEST, MaxQuant, etc.). The applicant will work with and help lead an interdisciplinary team of scientists consisting of faculty, postdocs, and graduate students to establish (ultra)sensitive quantitative workflows to enable the interrogation of molecular mechanisms that are critical for cell differentiation and embryonic development but have been unavailable for investigation due to limitations in analytical sensitivity. The ideal candidate is already experienced in routinely operating and maintaining the Ultimate 3000 RSLCnano Orbitrap Fusion Lumos system. Experience in tools of molecular biology is a bonus. Prior experience in working with the AB Sciex CESI capillary electrophoresis instrument is a bonus but is not required. Experience working with custom-built instrumentation or custom-building instrumentation is welcome but is not required. The proactive and self-motivated candidate will have the opportunity to learn new skills in ultrasensitive proteomics, mass spectrometry instrumentation, and cell/developmental biology. The NRG owns a comprehensive suite of mass spectrometers, LC and CE systems, bioinformatics software packages, a live animal colony, and all the infrastructure to provide a productive experience for the motivated post-doctoral scientist. The position is open until filled.

Requirements
MINIMUM QUALIFICATIONS. Candidates should have a Ph.D. in Chemistry, Biochemistry, Biology or a related field, and have a demonstrated record of excellence in research, publications, and strong communication skills. Candidates must have already existing experience in bottom-up proteomic workflows of sample preparation, nano-flow liquid chromatography, orbitrap mass spectrometry, multiplexing quantification (e.g., TMT, iTRAQ). The candidates must possess sufficient experience in bioinformatics to be able to process proteomic MS data for statistical analyses (e.g., using SEQUEST, MaxQuant. The candidate should have good communication skills and work effectively in an interdisciplinary team of chemists, biologists, and engineers. The candidate must have the ability to work independently to achieve project objectives, meet project deadlines and reporting requirements, and help mentor other group members, including undergraduates.

Apply online at https://asms-jobs.careerwebsite.com/job/postdoctoral-associate-in-ultrasensitive-proteomics-mass-spectrometry/55473164/
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Univ. Maryland: Postdoctoral Associate (Ultrasensitive Metabolomics)

Posted: February 4, 2021
Location: College Park, MD

The Nemes Research Laboratory (NRG) has pioneered ultrasensitive metabolomics, peptidomics, and proteomics methodologies/technology for cell and developmental biology and neuroscience and has discovered molecules capable of altering normal cell fate decisions (see group website: http://blog.umd.edu/nemes/). The NRG is hereby seeking a talented and motivated postdoctoral researcher with existing experience in metabolomics/peptidomics, including steps of sample preparation for cells/tissues, micro/nano-flow liquid chromatography, orbitrap/time-of-flight/ion mobility mass spectrometry, and bioinformatics to process quantitative mass spectrometry data. The applicant will work with an interdisciplinary team of scientists consisting of faculty, postdocs, and graduate students to establish (ultra)sensitive quantitative workflows to enable the interrogation of molecular mechanisms that are critical for development but have been unavailable for investigation due to limitations in analytical sensitivity. The ideal candidate is already experienced in: Ultimate 3000 RSLCnano, Thermo Orbitrap Fusion Lumos, Waters NanoAcquity UPLC, Bruker Impact HD, Bruker TimsTOF PASEF, or AB Sciex CESI capillary electrophoresis system. Experience working with custom-built instrumentation or custom-building instrumentation is welcome but is not required. The proactive and self-motivated candidate will have the opportunity to learn new skills in ultrasensitive metabolomics-peptidomics-proteomics, mass spectrometry instrumentation, cell/developmental biology, and neuroscience. The NRG owns a comprehensive suite of mass spectrometers, LC and CE systems, bioinformatics software packages, a live animal colony, and all the infrastructure to provide a productive experience for the motivated post-doctoral scientist. The position is open until filled.

Requirements
MINIMUM QUALIFICATIONS. Candidates should have a Ph.D. in Chemistry, Biochemistry, Biology or a related field, and have a demonstrated record of excellence in research, publications, and strong communication skills. Candidates must have already existing experience in metabolomic and/or peptidomics workflows of sample preparation, nano-flow liquid chromatography, orbitrap/time-of-flight/ion mobility mass spectrometry, and relative/absolute quantification by mass spectrometry. The candidates must possess sufficient experience in bioinformatics to be able to process metabolomics/peptidomics mass spectrometry data for statistical analyses (e.g., using Skyline, MetaboAnalyst). The candidate should have good communication skills and work effectively in an interdisciplinary team of chemists and biologists. The candidate must have the ability to work independently to achieve project objectives, meet project deadlines and reporting requirements, and help mentor other group members, including undergraduates.

Apply online at https://asms-jobs.careerwebsite.com/job/postdoctoral-associate-in-ultrasensitive-metabolomics-mass-spectrometry/55473171/
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Interfolio: Post-doctoral Research Associate (Microbiology)

Posted: January 27, 2021
Location: Glendale, AZ

This opportunity is located in the School of Mathematical and Natural Sciences at ASU’s West campus (see School info at https://newcollege.asu.edu/mns). Given the multidisciplinary nature of the research, a highly self-directed, creative and self-motivated individual is sought. The laboratory is currently engaged in funded projects examining the role of the human microbiome, vitamin D, and neurotransmitters in gastrointestinal illnesses, including Irritable Bowel Syndrome (IBS) and pediatric Inflammatory Bowel Disorder (IBD). The research team also continues to pioneer new, very rapid mass spectrometry-enabled techniques to characterize individual microorganisms and microbial mixtures/communities. The position is a fulltime appointment with an anticipated start date between 6/1/2021 and 9/1/2021. The appointment will be made initially for one year with possibility of extension for additional years. Salary range is dependent on experience, with associated University benefits.

The individual in this position will provide microbiology and molecular biology support for research programs utilizing technical and problem-solving skills of biotechnology to fit the needs of research projects. Specifically, this individual will:

Supervise research personnel, including undergraduate researchers
Conduct microbiology and molecular biology-based experiments as required to meet the goals of existing projects and as identified by PI
Contribute and analyze data for research publications, grants, and grant reports
Draft manuscripts for publication reporting results of original research
Collaborate on grant applications for external funding to augment existing projects, and to advance projects in new directions
Operate and maintain specialized laboratory equipment such as a MALDI-TOF mass spectrometer, a microarray scanner, thermal cyclers, agarose gel equipment, spectrophotometers, power supplies, cryogenic freezers, and computer workstations.
Analyze complex datasets, including MALDI-TOF spectra, genomic and metagenomics data, phylogenetic data, using appropriate computer software and statistics
Prioritize and coordinate the use of laboratory space and equipment
Maintain and preserve bacterial freezer stock cultures
Maintain detailed records of research operations in a laboratory notebook
Order supplies as required to support microbiology, molecular biology and biochemistry experiments
Work as part of research team to preserve the organization, cleanliness, and biosafety of a BSL-2 laboratory, and associated common laboratory space
Maintain a dynamic, engaging laboratory webpage highlighting current research projects, researchers, products, opportunities, and publications

DAYS AND SCHEDULE: Varies. Normally 40 hours M-F; some evenings and weekends.

Essential Functions of the Position:
Conduct experiments in microbiology and molecular biology that advance development of novel methods to detect and characterize microbial isolates, communities, and biosignatures. Collect, analyze, evaluate, interpret organize, and synthesize data using appropriate computational, quantitative, presentation, and visualization tools. Conduct critical and highly technical components of research projects (summarized at: https://sites.google.com/a/asu.edu/sandrin-lab/research-in-the-sandrin-lab), including complex laboratory procedures carried out with materials which require constant monitoring for difficult to observe changes. This involves the assay, measurement and manipulation of very small samples, as well as modification of standard procedures to meet the needs of the project. Incumbent will also perform the day-to-day supervision and coordination of members of the research group, taking charge of the execution of the research project. Additional duties will involve planning, designing and implementing research projects utilizing microbiology, molecular biology, and metagenomics techniques, as well as assistance in writing research proposals and the co-authoring of research manuscripts for publication. The incumbent will also order and restock supplies and equipment, as well as maintain lab equipment in operating order. Work with potentially hazardous materials including toxic chemicals and pathogenic microorganisms. Ensure strict adherence to biosafety procedures. Excellent oral and written communication skills required. Lift up to 40 pounds.

Required Qualifications:
Ph.D. in a field appropriate to the area of assignment

Desired Qualifications:
Demonstrated commitment to working successfully with and mentoring a diverse student population, including first-generation college students
Experience mentoring undergraduate and graduate students in the research laboratory setting
Experience with molecular approaches to microbial biosignature characterization, including techniques in microbial community fingerprinting (e.g., 16S rDNA PCR, qPCR, genomics, metagenomics, and/or mass spectrometry-enabled (particularly MALDI-TOF) approaches)
Fluency in computational tools to facilitate rigorous, quantitative microbiome analysis (such as QIIME2, R, and/or other appropriate microbiome data analysis software packages)
Experience and/or interest in development of undergraduate laboratory course exercises that introduce students to state-of-the-art research tools

Application Instructions
The initial application deadline is March 1, 2021 at 11:59 p.m., Eastern Standard Time. Applications will continue to be accepted on a rolling basis for a reserve pool. Applications in the reserve pool may then be reviewed in the order in which they were received until the position is filled. A background check and official transcripts are required prior to employment.

Application Procedure:

Only electronic submissions via Interfolio will be reviewed. Incomplete applications will not be considered.

Applications must contain:
Cover letter that addresses the required and desired qualifications
Curriculum vitae with contact information, including telephone number and e-mail address
Unofficial graduate transcripts
Information for three professional references (their position, title, e-mail, phone number)
A statement with specific examples and indication of impact that describes how your teaching and/or research interests and experience have intersected with and/or will contribute to matters of justice, equity, diversity and inclusion

Apply online at https://apply.interfolio.com/83365
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EMAST: Instrument Technician

Posted: January 19, 2021
Location: Auburn, CA

Electrophoretic Mass Spectrometry Technology Corporation (EMAST) has an immediate opening for an Instrument Technician (permanent, full time with salary based on experience) with mass spectrometry instrumentation experience to join our growing R&D team in Auburn, CA (a small community 30 miles east of Sacramento in the Sierra foothills with a lower cost of living and a wider range of outdoor activities than larger metropolitan areas). EMAST is a well-funded US research and development company that is designing a fully integrated capillary electrophoresis – time of flight mass spectrometry system for initial introduction in China, and has accomplished the first milestone of this project by producing an alpha prototype to achieve the required proof of principle.

The successful candidate will be involved in the beta prototype and pre-production phases of this project to carry out experiments and various tasks related to CE-MS instrumentation under the guidance of Dr. Josh Wiley, the Project Manager for this unique instrument. A BS or MS in science or engineering with 2-5 years of related experience is required, although specific experience with CE and/or MS instrument development, vacuum technology, PCB troubleshooting, digital logic and electrical schematics would be a plus.

For additional information or to submit a resume, please email kerry.nugent@warplcms.com.
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EMAST: Research Scientist

Posted: January 8, 2021
Location: Auburn, CA

Electrophoretic Mass Spectrometry Technology Corporation (EMAST) has an immediate opening for a research scientist (permanent, full time with salary based on experience) with mass spectrometry experience to join our growing R&D team in Auburn, CA (a small community 30 miles east of Sacramento in the Sierra foothills with a lower cost of living and a wider range of outdoor activities than larger metropolitan areas). EMAST is a well funded US company that is developing a fully integrated capillary electrophoresis – mass spectrometry system and has accomplished the first milestone of this project by producing an alpha prototype to achieve the required proof of principle.

The successful candidate will be involved in the beta prototype and pre-production phases of this project to carry out experiments and various tasks related to CE-MS instrumentation and methods development. A BS or MS in science or engineering with 2-5 years of related experience is required, although specific experience with CE and/or MS instrument development, vacuum technology, PCB troubleshooting, digital logic and electrical schematics would be a plus.

For additional information or to submit a resume, please email kerry.nugent@warplcms.com.
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Johns Hopkins: Core Research Laboratory Technologist

Posted: December 7, 2020
Location: Baltimore, MD

Duties and responsibilities:
This technical position of Research Lab Technician is to perform sample preparation, matrix-assisted laser desorption/ionization (MALDI) imaging, and data analysis in the Applied Imaging Mass Spectrometry (AIMS) Core at The Johns Hopkins Medical Institutions. The candidate will closely work with and support the users of the AIMS Core under the supervision of the AIMS Core director. He/She is expected to section frozen or formalin-fixed paraffin-embedded (FFPE) tissues obtained from users onto conductive slides, use a robotic sprayer to spray enzymes/matrix onto tissue sections, set up MALDI imaging experiments, perform histology stains, and perform imaging data analysis under guidance. The candidate is expected to be knowledgeable about MALDI imaging analysis, SCiLS lab, iLAB, MATLAB, and statistical analysis methods. The candidate is expected to prepare reports about the obtained results in powerpoint and excel to be sent to users. The candidate is expected to frequently interact with AIMS Core users, requiring good people skills. The candidate is also expected to keep the AIMS Core facility clean, monitor inventory levels, order materials and supplies as needed, and keep records of all experiments performed in accordance with established policies and procedures.

Communication:
Good people skills and good communication skills required. Exchanges information in an appropriate manner requiring good oral and written communication skills.

Education / Experience:
Required: B.Sc in chemistry or related field required. M.Sc. in chemistry or related field preferred. Preferred science courses with lab & research lab experience in analytical chemistry. Mass spectrometry, liquid chromatography mass spectrometry (LC-MS), high performance liquid chromatography (HPLC), MALDI mass spectrometry or MALDI imaging experience strongly preferred.

Experience:
Background in analytical chemistry and mass spectrometry and HPLC required. Some related work experience preferred in a comparable lab performing MALDI mass spectrometry imaging, MALDI mass spectrometry, or other mass spectrometry imaging techniques, coupled with a general knowledge of biochemical/biological sciences or related field. Must be detail oriented, keep clear experimental records, have effective organizational skills, and be able to prioritize workload appropriately. Must be able to perform multiple tasks efficiently and correctly, often operating more than one instrument at a time. Experience in laboratory procedures and good computer skills required.

Any specific physical requirements for the job: Must be able to lift 25 lbs., must be able to sit for long period of time, and must be able to climb at least 4 flights of stairs.

Supervisory responsibility (indicate the number and type of persons supervised by incumbent): 0

Budget authority (indicate dollar amount of budget managed and type/level of authority): Will work in iLAB to approve billing of users. Will order supplies based on need in SAP.

To apply to this position, please email Dr. Kristine Glunde at kglunde1@jhmi.edu
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NIH: Postdoctoral Fellow

Posted: December 4, 2020
Location: Rockville, MD

The National Center for Advancing Translational Sciences (NCATS), a major research component of the National Institutes of Health, seeks applications from qualified candidates to fill a postdoctoral mass spectrometry position in the Analytical Chemistry Core Facility within NCATS’ Division of Preclinical Innovation in Rockville Maryland. The selected candidate must have expertise in mass spectrometry, high-performance liquid chromatography (HPLC) and proteomics fields. Applicants with additional expertise in protein biochemistry, automation systems and high-throughput screening will receive preferential consideration.

The Analytical Chemistry Core Facility maintains a state-of-the-art laboratory, the mission of which is to support chemistry research throughout the Center. The laboratory has a variety of instrumentation utilizing various analytical techniques, including liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, high-resolution mass spectrometry and nuclear magnetic resonance to facilitate early-stage chemical development. Initially focused on small-molecule purification and analysis, the laboratory’s capabilities have expanded to other therapeutic modalities, such as peptides, proteins, antibody-drug conjugates and lipids. The laboratory manages several cutting-edge mass spectrometers with the capability to perform high-throughput sample analysis, peptide and protein analysis (top-down and bottom-up), post-translational modification analysis, multiple reaction monitoring (MRM), proteomics, metabolomics, and ultra-high-resolution analysis of small molecules. NCATS’ goal is to increase the productivity, efficiency and integrity of chemistry efforts by optimizing workflows and integrating automated processes.

Core Responsibilities
The postdoctoral fellow will work as part of a multidisciplinary team of innovative scientists using the available resources to develop novel methods and assays for high-throughput proteomics analysis and mass spectrometry-based compound screening. The postdoctoral fellow will be expected to work independently as a well-trained problem solver in the areas of mass spectrometry and HPLC. He or she will manage, troubleshoot and regularly maintain the instrumentation. The fellow will be expected to prepare samples of various modalities prior to analysis. The fellow also will be required to keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. He or she will draft technical reports, manuscripts and patent applications, as well as present work at internal and external meetings.

Qualifications
The successful applicant must possess a Ph.D. in analytical chemistry, biochemistry or a related discipline, with a focus in mass spectrometry and have relevant research experience. Candidates should possess extensive proteomics experience, including sample preparation, post-translational modification analysis and data analysis, using Proteome Discoverer, MaxQuant, Mascot and/or Skyline. Direct experience with ultra-HPLC/nano-HPLC instrumentation is a must. Familiarity with the RapidFire high-throughput sampling system and protein biochemistry is necessary. Training in the areas of metabolomics, lipids analysis, MRM, intact protein and protein top-down analysis is desirable. The ideal candidate should be self-motivated, possess a strong work ethic, have a keen attention to detail, and be able to work on multiple projects simultaneously. Excellent analytical, organizational and time-management skills are required. The candidate must possess strong oral and written communication skills with a proven publication record in peer-reviewed journals. Applicants must be eligible to work in the United States for any employer.

How to Apply
Please submit a cover letter describing your interest in the position, including a research summary (1–2 pages); a current curriculum vitae and complete bibliography; and the names and contact information for at least three references to Dr. Christopher LeClair at ncats_info@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled.
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USDA: Postdoctoral Associate

Posted: October 20, 2020
Location: Beltsville, MD

The Method Application and Food Composition Laboratory (MAFCL) of USDA Agricultural Research Service, Beltsville Human Nutrition Center is seeking a post-doc associate in Analytical Chemistry or a closely related field. The successful candidate will work with an experienced research team to conduct metabolomic studies using UHPLC HRAM MS/MS in herbs, dietary supplements, and foods, as well as identify/quantify key bioactive compounds.

HPLC and MS experience are required. Experiences in high-resolution MS and small molecule characterization and quantification are preferred. Chemometric experience is a plus. The laboratory’s research crosses the boundaries between analytical chemistry, natural product/botanical, and human nutrition. Please visit us at for more information.

The position is located in Beltsville, Maryland, USA . For more information regarding the lab, please go to https://www.ars.usda.gov/northeast-area/beltsville-md-bhnrc/beltsville-human-nutrition-research-center/methods-and-application-of-food-composition-laboratory/

To be considered for this position, please email your Curriculum vitae to: pei.chen@usda.gov.
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FDA CBER: Postdoctoral Fellow

Posted: October 21, 2020
Location: Silver Spring, MD

A research opportunity is currently available in the Office of Vaccines Research and Review (OVRR), at the Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA) in Silver Spring, Maryland. This research opportunity will be within the Laboratory of Bacterial Polysaccharides with the goal of using recombinant technologies, metabolic engineering and/ synthetic biology as tools to improve the understanding of glycoconjugate vaccine synthesis and immunology. The selected participant will receive mentoring on fulfilling the project, which will also include collaboration with investigators within and external to the FDA. The participant will be studying Glycoengineered Outer Membrane Vesicles (geOMV) as an alternative platform to generate glycoconjugate vaccines that target encapsulated pathogens. The participant will generate a prototype expression system to reconstitute bacterial polysaccharides (e.g. capsule, O-antigen) in Escherichia coli, and test and evaluate the immune response of the purified geOMV.

Qualifications
The qualified candidate should have received a Doctoral degree in biochemistry, molecular biology or related field. Degree must have been received within five years of the appointment start date. Applicants must have resided in the USA for 3 of the last 5 years.

Preferred skills:
• Biochemistry and molecular biology, such as designing and cloning plasmid constructs, bacterial and tissue cultural techniques, recombinant protein expression and purification, PAGE/Western blot protein analysis and performing respective functional / binding assays
• Knowledge of glycobiology and mass spectrometry

The following papers provide examples of the research project:
1. Haurat MF et al. Biol Chem. 2015. doi: 10.1515/hsz-2014-0183
2. Elhenawy, W. et al. MBio. 2016. 10.1128/mBio.00940-16
3. Price, N. L. et al. Sci Rep. 2016. doi: 10.1038/srep24931

How to apply:
Interested applicants should send their curriculum vitae, statement of research interests, along with contact information for three references to:
Dr. M. Florencia Haurat
maria.haurat@fda.hhs.gov
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USDA: Postdoctoral Associate

Posted: October 20, 2020
Location: Beltsville, MD

The Method Application and Food Composition Laboratory (MAFCL) of USDA Agricultural Research Service, Beltsville Human Nutrition Center is seeking a post-doc associate in Analytical Chemistry or a closely related field. The successful candidate will work with an experienced research team to conduct metabolomic studies using UHPLC HRAM MS/MS in herbs, dietary supplements, and foods, as well as identify/quantify key bioactive compounds.

HPLC and MS experience are required. Experiences in high-resolution MS and small molecule characterization and quantification are preferred. Chemometric experience is a plus. The laboratory’s research crosses the boundaries between analytical chemistry, natural product/botanical, and human nutrition. Please visit us at for more information.

The position is located in Beltsville, Maryland, USA . For more information regarding the lab, please go to https://www.ars.usda.gov/northeast-area/beltsville-md-bhnrc/beltsville-human-nutrition-research-center/methods-and-application-of-food-composition-laboratory/

To be considered for this position, please email your Curriculum vitae to: pei.chen@usda.gov.
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Bruker: Field Sales Representative

Posted: October 6, 2020
Location: Washington, DC – Baltimore, MD

Bruker Daltonics Inc. is seeking a Field Sales Representative for the Mid-Atlantic Territory – VA, DC, MD, DE, PA for Life Science Research Mass Spectrometry.

Primary Responsibilities:
• Meets or exceeds assigned territory sales target by maintaining & growing sales in current accounts, and identifying & closing business in new accounts.
• Accurately forecasts prospects through sales cycle. Maintains balance & list of prospects that reflects sales targets and tracks this in CRM. Interprets customer needs & identify BDAL solutions. Builds & articulates BDAL value proposition. Understands customer decision making process, and key decision makers and influencers.
• Cultivates key accounts / key opinion leaders.
• Provides sales territory information, forecasts, reports and other business data through the BDAL management structure.
• Completes a business plan for the assigned territory detailing specific strategies and activities required to achieve goals.
• Identifies & works with internal resources to enhance customer interaction through sales process.
Secondary Responsibilities:
• Maintains & enhances sales skills through technical & sales training.
• Develops & maintains territory opportunities in the SalCRMCRM database.
• Maintains & enhances technical knowledge on BDAL products, company literature & information, and competition.
• Maintains knowledge to discuss commercial contract terms.
• Education and/or Experience:
• Minimum of a Bachelor’s degree in chemistry/biochemistry, or equivalent scientific degree or equivalent work experience required.
• Minimum of five years’ sales experience in related industry, with demonstrated success, required.

Computer Skills:
• Essential to have experience with contact management database software (eg Microsoft Dynamics CRM or SFDC), and MS Office. Must be able to learn new software packages; e.g. Adobe Acrobat.

Certificates, Licenses, Registrations:
• Must have & be able to maintain valid travel documentation and driving license.

Other Skills and Abilities:
• Excellent communications skills needed to work with a wide variety of knowledge levels with customers of differing backgrounds, and within BDAL (e.g. management, service applications).
• Excellent presentation, interpersonal, and organization skills.
• Ability to decide priorities in a rapidly changing commercial environment.

Other Qualifications:
• Must be able to maintain home office with telephone lines and computer connectivity. Must have flexibility, ability to prioritize and manage differing time constraints: time management is essential. In depth industry knowledge.
• Self-motivation is essential as is a willingness to work with others toward a shared goal.
• Willingness and ability to travel, as extensive travel within the territory is required. (~70%)

Apply online through LinkedIn
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Medical Science & Computing: Proteomics Scientist

Posted: September 18, 2020
Location: Bethesda, MD

MSC is searching for a Proteomics Scientist to provide support to the National Institutes of Health (NIH). This opportunity is a full-time position with MSC and it is on-site in Bethesda, Maryland.
Operate and maintain nanoflow liquid chromatography and mass spectrometer (orbitrap fusion Lumos).
Prepare samples for mass spectrometry
Establish proteomics methods
Obtain and analyze mass spectrometry data
Maintain laboratory equipment
Order and maintain supplies

Requirements
Ph.D. in Biochemistry, Chemistry, Proteomics or related field.
Three (3) or more years of experience in proteomics research.
Experience with proteomics pipeline (sample preparation, LC and MS operation, and data analysis).
Experience with MS data analysis software.
Must be able to work independently and as part of a team and be self-motivated.
Strong organizational and communicational skills.
Experience with orbitrap fusion Lumos is advantageous.

Apply online at https://careers-mscweb.icims.com/jobs/4168/proteomics-scientist/job
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