October Meeting

Posted on by

Speaker: Gabriella Weiss, NASA

Topic: Measuring intramolecular carbon isotope distributions in amino acids using Fourier transform mass spectrometry

Date: October 14, 2024

Time: 6:15 pm Dinner, 7:15 pm Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Dingyin Tao (owendtao@gmail.com) by Friday, October 11 if you will be attending the dinner.

Abstract: Molecules form via the addition of single atoms or subunits of atoms and measuring the isotopic composition of different parts of a molecule can provide information about its synthesis as well as alteration by biological and abiotic processes. Molecule fragmentation using mass spectrometry is a common form of compound identification and recently, this has been leveraged to investigate the isotopic composition of specific compound moieties. Historically, intramolecular isotope measurements (i.e., position-specific isotope analysis, PSIA) were laborious, requiring large amounts of analyte and specialized instrumentation. Here, we discuss the use of Fourier transform mass spectrometry (FT-MS) for making molecular average and position-specific isotope measurements. FT-MS (i.e., Orbitrap mass spectrometry) permits the measurement of isotope ratios of intact molecules and their fragments without requiring conversion to simple gases like CO 2 . We focus on the analysis of amino acids and how PSIA of amino acids can be used to distinguish biological and abiotic processes.

Shimadzu Pharma Summit

Posted on by

Date
Tuesday, October 15, 2024
Time
9:00 AM to 5:00 PM
Location
Boston Marriott Cambridge
50 Broadway, Cambridge, MA 02142

Agenda
Enabling the Future of Pharma Through Analytics
Kevin Bateman, Ph.D.

AI-driven Process and Analytical Development
Eric Fang, Ph.D., Snapdragon Chemistry

Identification of a Novel Kinase Inhibitors using AI-led Drug Discovery and Physics-based Simulations
Sangamesh Badiger, Ph.D., Aurigene Pharmaceutical Services

Shimadzu Living Laboratory
Lakshmi Narayana, Ph.D., Daicel Chiral Technologies India Pvt

Identification and Quantification of Co-eluting Impurities in Pharmaceutical Analysis by i-PDeA
Dawen Kou, Ph.D., Genentech

Laser Desorption in Biological Analysis
Koichi Tanaka, Nobel Laureate, Shimadzu

Pharma Summit Invitation_Oct 15 2024
Register at https://ssi-shimadzu-8076067.hs-sites.com/2024pharmasummit

September 2024 Meeting and Vendor Night

Posted on by

Speaker: Neil L. Kelleher, Northwestern University

Topic: Digitizing Proteoform Biology with Single Molecule & Single Cell Mass Spectrometry

Date: Monday, September 16, 2024

Time: 6:00 pm Dinner and Vendor Night, 7:15 pm Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions) This will be an in-person meeting.

Dinner: Please RSVP to Dingyin Tao (owendtao@gmail.com) by Friday, September 13 if you will be attending the dinner.

Abstract: Since the completion of the Human Genome Project, much has been made of the need to bridge the gap from genes and traits. As a key nexus for the many interacting ‘-omes’ (genome, transcriptome, proteome, metabolome, etc.), the proteome should offer a tight link between genotype and phenotype. Proteoforms, or all of the precise molecular forms of a protein, capture all sources of variability in protein composition (i.e., SNPs, isoforms, post-translational modifications), and thus provide crucial insights into regulation and function. Now, “single ion” mass spectrometry is poised to convert genes to proteoform signatures at a far faster rate. Recently we developed proteoform imaging mass spectrometry (PiMS), with individual ion mass spectrometry. This platform has been extended now to single-cell Proteoform imaging Mass Spectrometry (scPiMS), boosting cell processing rates by >20-fold in the field while detecting proteoforms from single cells.

FeMS+ “Out of the Shadows” Leadership Development Program

Posted on by

Females in Mass Spectrometry (FeMS+) is hosting a one-day leadership event in Rockville, MD for women scientists.

FeMS+ is a community-led initiative to create a worldwide network of support for women in mass spectrometry. “Out of the Shadows” is our premiere Leadership Development program for women in mid- to senior-level positions aiming to advance their career. Since 2023, we have held four “Out of the Shadows” events, in San Jose, US; Munich and Hamburg, Germany; and Singapore.

The “Out of the Shadows” event will be held on Tuesday September 10, 2024 in Rockville, MD, co-sponsored by CASSS and SCIEX. Registration is free. Application is now open and will close on July 30, 2024. To apply, please visit https://femalesinms.com/out-of-the-shadows-leadership-development-program/ The September leadership event focuses on powering up executive presence. There will be interactive professional coaching, practical exercises, and group discussion.

FeMS-OTS-Cohort-6-Flyer-1

Chemical Tags for Quantitative Omics Workshop

Posted on by

August 2, 2024
University of Wisconsin – Madison on Zoom

This interactive workshop will cover the fundamentals of chemical tagging for quantifying -omics on a mass spectrometer.
This is a beginner level workshop, open to anyone who has at least six months of mass spec experience. This workshop will be a mix of lectures, demos, and discussion, topics include:
· Fundamentals and overview of chemical labeling approaches to quantitative proteomics
· Data Analysis Lecture
· Research Lecture on High-throughput quantitative top-down proteomics using intact protein-level tandem mass tag (TMT) labeling
· Applications of DiLeu tags for quantitative PTM analysis and biomarker discovery
· Development and application of isobaric tags for quantitative glycomics and lipidomics
· Research Lecture on Unlocking the secrets of complex proteotypes with sample multiplexing-based quantitative proteomics

Registration can be found at https://www.ncqbcs.com/resources/training/tagging-training/

There is no cost to attend due to generous support from the National Institutes of Health and the National Center for Quantitative Biology of Complex Systems (P41 GM108538).
Omics_Workshop_Schedule