Speaker: Benjamin Orsburn, Think20 Labs

Topic: Removing the Limiters – New Data Processing Methods to Realize the True Potential of Today’s LCMS Technology

Date: Monday, May 20, 2019

Time: 6:15 pm Dinner, 7:15 pm Presentation

Location: Shimadzu Scientific Instruments, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Yan Wang (yan.wang2@nih.gov) by Friday, May 17th if you will be attending the dinner.

Abstract: Classical approaches to proteomic data processing have many shortcomings in terms of the identifications of mutations, individual genetic variants and post-translational modifications. Nearly all shotgun proteomic data processing is performed by matching MS/MS spectra against small, curated canonical databases that do not reflect the individual variation of the organism or tissue being studied. Incorporation of “next generations” sequencing technology outputs and improved software and hardware solutions can allow us to now see a bigger picture of the true proteomes of our tissues than ever before. In this talk I will describe recent methods and technologies that allow us to look outside of our old boxes and see the data that we’ve been missing.