December 2018 Meeting

Speaker: Amina Woods, The National Institute on Drug Abuse Intramural Research Program

Topic: Tracking the Progression of Traumatic Brain Injury and the Therapeutic Response to a Peptide Drug Using Innovative Imaging MS

Date: Monday, December 17, 2018

Time: 6:15 pm Dinner, 7:15 pm Presentation

Location: Shimadzu Scientific Instruments, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Yan Wang ( by Friday, December 14th if you will be attending the dinner.

Abstract: Traumatic brain injury (TBI) is a serious public health problem and a leading cause of death in children and young adults. It also contributes to a substantial number of cases of permanent disability. As lipids make up over 50% of the brain mass and play a key role in both membrane structure and cell signaling, their profile is of interest. In this study, we show that advanced mass spectrometry imaging (MSI) has sufficient technical accuracy and reproducibility to study the progression of TBI as well as a therapeutic response. The anatomical distribution of 50 μm diameter microdomains demonstrate changes in brain lipid levels in a rat model of controlled cortical impact (CCI) 3 days post injury with and without treatment.