December 15, 2008 WBMSDG Meeting

Speaker: Dr. Justin Hettick; CDC NIOSH in Morgantown

Topic: Discrimination of microorganisms by MALDI-TOF MS

Abstract: Unambiguous identification of microorganisms such as bacteria or fungi is essential for effective surveillance and treatment of disease.  Unfortunately, diagnosis by classical microbiological methods often requires lengthy culture procedures or subjective micro-and macroscopic evaluations.  To stem the spread of disease, rapid procedures for the accurate identification of microorganisms are necessary.  To that end, we have been developing mass spectrometry-based tools for the analysis of bacteria and fungi.

Matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry (TOF-MS) can be used to generate highly reproducible, characteristic “fingerprint” mass spectra.  These “fingerprint” mass spectra may be reduced to a subset of significant mass-to-charge values through statistical tools and compared against a reference library.  Using this technique, microorganisms can be easily identified at the species and strain level with error rates approaching zero.

Time: 7:30 pm

: Shimadzu Scientific Instruments, Inc. Training Center, 7100 Riverwood Drive, Columbia, MD 21046

: Shimadzu Scientific Instruments

2016 – 2017 Officers



Dr. Katherine (Katie) Fiedler
US FDA/Center for Food Safety and Applied Nutrition (CFSAN)
5100 Paint Branch Parkway
College Park, MD 20740
Phone: (240) 402-5055

Dr. Stefani Thomas
Johns Hopkins University School of Medicine
Department of Pathology, Division of Clinical Chemistry
Center for Biomarker Discovery and Translation
1550 Orleans St., CRBII Room 3M03
Baltimore, MD 21231
Phone: 410-955-7138

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Dr. G. Asher Newsome
ERP International, LLC
contractor to Department of Research Programs, Walter Reed National Military Medical Center
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Bethesda, Maryland 20889-5638
Phone: 301-295-8293


Dr. Berk Oktem


Dr. Alexei Gapeev
Millis Scientific, Inc
6400 Baltimore National Pike #201
Baltimore MD 21228
Phone: 877-844-2635

About the WBMSDG

The Greater Washington-Baltimore Mass Spectrometry Discussion Group meets monthly from September through June to discuss various aspects of mass spectrometry.