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October Meeting

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Speaker: Gabriella Weiss, NASA

Topic: Measuring intramolecular carbon isotope distributions in amino acids using Fourier transform mass spectrometry

Date: October 14, 2024

Time: 6:15 pm Dinner, 7:15 pm Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Dingyin Tao (owendtao@gmail.com) by Friday, October 11 if you will be attending the dinner.

Abstract: Molecules form via the addition of single atoms or subunits of atoms and measuring the isotopic composition of different parts of a molecule can provide information about its synthesis as well as alteration by biological and abiotic processes. Molecule fragmentation using mass spectrometry is a common form of compound identification and recently, this has been leveraged to investigate the isotopic composition of specific compound moieties. Historically, intramolecular isotope measurements (i.e., position-specific isotope analysis, PSIA) were laborious, requiring large amounts of analyte and specialized instrumentation. Here, we discuss the use of Fourier transform mass spectrometry (FT-MS) for making molecular average and position-specific isotope measurements. FT-MS (i.e., Orbitrap mass spectrometry) permits the measurement of isotope ratios of intact molecules and their fragments without requiring conversion to simple gases like CO 2 . We focus on the analysis of amino acids and how PSIA of amino acids can be used to distinguish biological and abiotic processes.

Shimadzu Pharma Summit

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Date
Tuesday, October 15, 2024
Time
9:00 AM to 5:00 PM
Location
Boston Marriott Cambridge
50 Broadway, Cambridge, MA 02142

Agenda
Enabling the Future of Pharma Through Analytics
Kevin Bateman, Ph.D.

AI-driven Process and Analytical Development
Eric Fang, Ph.D., Snapdragon Chemistry

Identification of a Novel Kinase Inhibitors using AI-led Drug Discovery and Physics-based Simulations
Sangamesh Badiger, Ph.D., Aurigene Pharmaceutical Services

Shimadzu Living Laboratory
Lakshmi Narayana, Ph.D., Daicel Chiral Technologies India Pvt

Identification and Quantification of Co-eluting Impurities in Pharmaceutical Analysis by i-PDeA
Dawen Kou, Ph.D., Genentech

Laser Desorption in Biological Analysis
Koichi Tanaka, Nobel Laureate, Shimadzu

Pharma Summit Invitation_Oct 15 2024
Register at https://ssi-shimadzu-8076067.hs-sites.com/2024pharmasummit

September 2024 Meeting and Vendor Night

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Speaker: Neil L. Kelleher, Northwestern University

Topic: Digitizing Proteoform Biology with Single Molecule & Single Cell Mass Spectrometry

Date: Monday, September 16, 2024

Time: 6:00 pm Dinner and Vendor Night, 7:15 pm Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions) This will be an in-person meeting.

Dinner: Please RSVP to Dingyin Tao (owendtao@gmail.com) by Friday, September 13 if you will be attending the dinner.

Abstract: Since the completion of the Human Genome Project, much has been made of the need to bridge the gap from genes and traits. As a key nexus for the many interacting ‘-omes’ (genome, transcriptome, proteome, metabolome, etc.), the proteome should offer a tight link between genotype and phenotype. Proteoforms, or all of the precise molecular forms of a protein, capture all sources of variability in protein composition (i.e., SNPs, isoforms, post-translational modifications), and thus provide crucial insights into regulation and function. Now, “single ion” mass spectrometry is poised to convert genes to proteoform signatures at a far faster rate. Recently we developed proteoform imaging mass spectrometry (PiMS), with individual ion mass spectrometry. This platform has been extended now to single-cell Proteoform imaging Mass Spectrometry (scPiMS), boosting cell processing rates by >20-fold in the field while detecting proteoforms from single cells.

FeMS+ “Out of the Shadows” Leadership Development Program

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Females in Mass Spectrometry (FeMS+) is hosting a one-day leadership event in Rockville, MD for women scientists.

FeMS+ is a community-led initiative to create a worldwide network of support for women in mass spectrometry. “Out of the Shadows” is our premiere Leadership Development program for women in mid- to senior-level positions aiming to advance their career. Since 2023, we have held four “Out of the Shadows” events, in San Jose, US; Munich and Hamburg, Germany; and Singapore.

The “Out of the Shadows” event will be held on Tuesday September 10, 2024 in Rockville, MD, co-sponsored by CASSS and SCIEX. Registration is free. Application is now open and will close on July 30, 2024. To apply, please visit https://femalesinms.com/out-of-the-shadows-leadership-development-program/ The September leadership event focuses on powering up executive presence. There will be interactive professional coaching, practical exercises, and group discussion.

FeMS-OTS-Cohort-6-Flyer-1

Chemical Tags for Quantitative Omics Workshop

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August 2, 2024
University of Wisconsin – Madison on Zoom

This interactive workshop will cover the fundamentals of chemical tagging for quantifying -omics on a mass spectrometer.
This is a beginner level workshop, open to anyone who has at least six months of mass spec experience. This workshop will be a mix of lectures, demos, and discussion, topics include:
· Fundamentals and overview of chemical labeling approaches to quantitative proteomics
· Data Analysis Lecture
· Research Lecture on High-throughput quantitative top-down proteomics using intact protein-level tandem mass tag (TMT) labeling
· Applications of DiLeu tags for quantitative PTM analysis and biomarker discovery
· Development and application of isobaric tags for quantitative glycomics and lipidomics
· Research Lecture on Unlocking the secrets of complex proteotypes with sample multiplexing-based quantitative proteomics

Registration can be found at https://www.ncqbcs.com/resources/training/tagging-training/

There is no cost to attend due to generous support from the National Institutes of Health and the National Center for Quantitative Biology of Complex Systems (P41 GM108538).
Omics_Workshop_Schedule