Friday, September 22nd, 2017

Available Positions


Smithsonian Institution: Postdoctoral Fellow

FDA: Postdoctoral Fellow

Salubris: Scientist/Senior Scientist/Principal Scientist

Protea Biosciences: Senior Scientist in Mass Spectrometry Imaging

MacroGenics, Inc.: Scientist I/Associate Scientist II

USDA Food Composition and Method Development Laboratory: Post-doctoral Fellowship

Icahn School of Medicine at Mt. Sinai: Senior Associate Researcher

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Smithsonian Institution: Postdoctoral Fellow

Posted: August 14, 2017
Location: Suitland, MD

The Office of Fellowships and Internships is offering an Interdisciplinary Postdoctoral Fellowship in the area of biomolecular mass spectrometry. Research proposals must focus on mass spectrometry analysis from any type of museum or research sample including artwork, objects, animal, or plant tissues. Projects must integrate one or more analytical techniques into their specific research plan including proteomics and biomolecular mass spectrometry, gas chromatography mass spectrometry, liquid chromatography mass spectrometry, ambient mass spectrometry, stable isotope mass spectrometry, or inductively coupled plasma mass spectrometry. Data collection and analysis via mass spectrometry should be the primary basis for informing and answering research questions and should constitute a significant portion of the research. The successful applicant will conduct analyses in at least one of the Smithsonian’s mass spectrometry facilities (MCI Biomolecular and Proteomics Mass Spectrometry Laboratory in Suitland, MD; MCI Stable Isotope Mass Spectrometry Facility in Suitland, MD; STRI Stable Isotope Laboratory in Panama City, Panama; MCI ICP-MS Laboratory in Suitland, MD; FSG Department of Conservation and Scientific Research).

Applicants must have completed or be near completion of the Ph.D. Recipients who have not completed the Ph.D. at the time of application must provide proof of completion of the degree before the fellowship begins. Please go here for details on the SI fellowship program. Applications must be submitted by December 1, 2017.

Applicants must propose to conduct research in-residence for a period of 12 months. Applicants interested in this fellowship are strongly encouraged to contact potential advisors/hosts at any of the Smithsonian’s various Museums and Research Units prior to proposal preparation and submission. The fellow can work exclusively with any of the mass spectrometry facilities listed above or jointly with a co-advisor in a different unit if desired. Please consult the research staff listed in SORS.

Applications for the Biomolecular Mass Spectrometry Postdoctoral Fellowship apply in SOLAA to the Biomolecular Mass Spectrometry Postdoctoral Fellowship listed under the Office of Fellowships. The application is not listed under the museum, research facility or office in which the applicant proposes to conduct research. Please follow the guidelines for the postdoctoral fellowship application. Please go here for details on the SI fellowship program. Apply Through: SOLAA

No employee or contractor of the Smithsonian Institution may hold a Smithsonian fellowship during the time of his/her employment or contract.

A fellowship may not be awarded to any person who has been employed by or under contract to the Institution in the previous year without the prior approval of the Office of Fellowships and Internships.

For general information about this fellowship, or additional information on the Museum Conservation Institute (MCI) Biomolecular and Proteomics Mass Spectrometry Laboratory, OUSS/MCI Stable Isotope Mass Spectrometry Facility, or the MCI ICP-MS Laboratory in Suitland, MD please contact Christine France (francec@si.edu).

For additional information on the Smithsonian Tropical Research Institute (STRI) Stable Isotope Laboratory in Panama City, contact Ben Turner (turnerbl@si.edu).

For additional information on the Freer-Sackler Gallery (FSG) Department of Conservation and Scientific Research, contact Blythe McCarthy (mccarbl@si.edu).

Access to the online application system and information regarding the necessary materials can be found here. Applications for 2018 will open in September 2017.
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FDA: Postdoctoral Fellow

Posted: July 27, 2017
Location: College Park, MD

The Division of Analytical Chemistry, Office of Regulatory Science of the U.S. Food and Drug Administration’s Center for Food Safety and Applied Nutrition (CFSAN) seeks a postdoctoral fellow to participate in our food safety/food defense research program. The primary research goals are the development and use of mass spectrometric techniques and complementary methods for the analysis of foods, food additives and dietary supplements for potential contaminants and adulterants. The applications include development of methods for the identification and quantitation of chemical contaminants and adulterants in foods, including biotoxins (bacterial, fungal and algal), allergens, and pesticide/industrial chemicals. These research projects are components of agency-wide, on-going food safety and food defense programs, which support important FDA policy and regulatory decisions.

Candidates should have a Ph.D. degree in Analytical Chemistry, Biochemistry or a related field, and a strong background and interest in learning and gaining experience with the latest liquid chromatographic and mass spectrometric techniques such as those for protein/peptide analysis. Training or experience in food science and food analysis method development is desirable. U.S. citizenship, permanent resident status or a valid J1 Visa is required (F1 with OPT is acceptable until a J1 is obtained). Please email your CV to: Dr. Tim Croley, US FDA/Center for Food Safety and Applied Nutrition, HFS-707, College Park, MD 20740. Timothy.Croley@fda.hhs.gov
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Salubris: Scientist/Senior Scientist/Principal Scientist

Posted: July 27, 2017
Location: Gaithursburg, MD

Salubris Biotherapeutics, Inc. (hereafter referred to as SalubrisBio) is a science-driven biotechnology company dedicated to discover and develop novel antibody therapeutics for the treatment of cancer and cardiovascular diseases. Our mission is to use innovative concept and technology to make a meaningful and impactful improvement in the health and lives of the patients. SalubrisBio is seeking highly motivated full-time scientists with exceptional ability to lead analytical development for product testing and characterization for antibody drug product development. The candidates shall have strong ability in multi-tasking and are expected to work in a fast paced, dynamic and changing start-up environment with high degree of self-motivation.

The company offers competitive benefits including medical, dental, vision and life insurance, as well as 401(k) match and paid time leave. SalubrisBio is an equal opportunity employer. To apply for this job, please contact Jinhua Feng (Jenny) at jinhua.feng@salubrisbio.com

Job Responsibilities:
• Act as the key expert in the characterization of protein, glycan, monoclonal antibody (mAb), antibody drug conjugate (ADC) using LC-MS, or other techniques. Provide scientific input into study design and execution
• Carry out physiochemical tests including, not limited to peptide mapping and intact mass using LC-MS, glycan, HPLC (SEC, Protein A, IEC, and HIC), CE-SDS, cIEF, etc
• Compile analytical data, perform data analysis and interpretation, prepare technical report, present data to project teams, give oral presentation at internal or external meetings
• Develop, qualify, and transfer physiochemical assays, prepare SOPs and assay development reports, and provide expertise guidance to troubleshooting
• Identify and define critical quality attributes (CQA) in early analytical development stage
• Effectively work with other functional teams: purification, cell culture, formulation, and QA
• Responsible for maintaining and ensuring adherence to cGMP compliance
• Support regulatory filing
• Order and maintain laboratory reagents and supplies, perform tasks as assigned

Qualifications:
• Education: MS or Ph.D. in Analytical Chemistry, Biochemistry, Biological Science
• MS with 7+ years or Ph.D. with 3+ years industry experience with primary focus on characterization and assay development for protein, glycan, mAb, or ADC
• Extensive hands-on experience in one or more area of peptide mapping, intact mass LC-MS, disulfide bond mapping, HPLC (Protein A, SEC, RP, IEC, HIC), electrophoresis
• Experience in post-translational modification characterization of proteins, glycan analysis, IND filing, report authoring, SOP authoring, assay development
• Able to introduce new technologies to improve the performance and efficiency of assays or to accelerate product characterization
• Strong technical competency in analytical development and troubleshooting for instrument failure, assay failure, or any testing failure
• Familiar with quality systems (cGMP) and quality operation philosophy
• Strong verbal and written communication skills, ability to manage multiple tasks simultaneously and to pay attention to details
• Self-motivated, well organized, and highly effective in team oriented environment
• Able to timely adjust to project priority change

To apply, email Jinhua Feng at jinhua.feng@salubrisbio.com
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Protea Biosciences: Senior Scientist in Mass Spectrometry Imaging

Posted: April 7, 2017
Location: Morgantown, West Virginia

Protea Biosciences provides innovative mass spectrometry imaging technologies, LAESI and MALDI MSI, proteomics, protein characterization and small molecule analysis. Our interdisciplinary team offers the expertise to support researchers’ projects and help accelerate drug discovery and characterization. Protea delivers the highest quality data from state-of-the-art approaches providing customers with confidence and confidentiality.

Summary:
Protea is seeking a dynamic individual to fill the role of Senior Scientist in Mass Spectrometry Imaging. The scientist is responsible for mass spectrometry imaging projects, which would include method development, sample preparation, operation of analytical instrumentation, and reporting of data.

Essential Functions:
Responsible for designing experiments to address customer questions, marketing requests and new applications in mass spectrometry imaging
Learn and apply techniques in mass spectrometry imaging including MALDI and LAESI or other analytical techniques as required
Complete projects successfully within the realm of service projects, application notes, proof-of-concepts, new method development, and collaboration projects
Data analysis, project reports, and discussion of data with clients

Qualifications:
PhD in analytical chemistry or related field
Three years or greater in field of mass spectrometry
Knowledge, understanding, and experience with mass spectrometry imaging is preferred but not required.
Experience with sample preparation (i.e. tissue sectioning) is preferred but not required.
Excellent organizational, analytical, and communication skills required.
Willingness to learn, assist others, and thrive in an enthusiastic team environment.
Must be goal oriented and have high attention to detail to all responsibilities assigned.
Technical writing and troubleshooting capabilities are required.
Excellent written and verbal communication skills are required
Ability to manage multiple tasks and prioritize workload is required.

Interested applicants should send their resumes to callee.walsh@proteabio.com.
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MacroGenics, Inc.: Scientist I/Associate Scientist II

Posted: March 9, 2017
Location: Rockville, Maryland

This position is responsible for characterizing biologic drug candidates by mass spectrometry and investigating the physiochemical properties, including early formulation and stability assessments. He/she will need to collaborate with biologists and process scientists to ensure the delivery of therapeutic molecules with the desired biological and biophysical properties and be responsible for purifying recombinant proteins and antibody reagents for biologics discovery programs.

Responsibilities and Job Duties:
* Perform characterization of primary structure by mass spectrometry including post translational modifications, disulfides, glycosylation, oxidation, deamidation, asp isomerization, and protolytic cleavage sites
* Ensure that the correct laboratory chemicals and consumables necessary to use the mass spectrometer are always available and for contacting the appropriate service engineers to provide regular maintenance and/or repair the equipment in a timely manner
* Conduct protein formulation and stability testing to determine appropriate storage conditions
Provide biophysical scientific guidance to the protein purification group for troubleshooting problems
* Assist with the interface between research and development for technology transfer of lead drug candidates
* Present ongoing updates to research and development project teams to ensure open and timely communications between the teams resulting in better understanding and a smooth transition
* Maintain accurate and timely laboratory notebooks and other data records to provide crucial information regarding discovery of inventions and to best understand the experimental process

Requirements
Education & Experience – Scientist I
PhD in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or related field
Prior experience characterizing proteins using mass spectrometry

Education & Experience – Associate Scientist II
Bachelors/Masters in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or related field
Minimum of 8 years of related experience with a Bachelors
Minimum of 5 years of related experience with a Masters degree
Relevant experience in biotech or pharmaceutical companies
Prior experience characterizing proteins using mass spectrometry

Knowledge, Skills and Abilities
Ability to provide a critical interpretation of results
Trouble shooting skills
Ability to multitask and handle multiple priorities in a fast-paced environment
Excellent written and verbal communications skills
Strong interpersonal skills for interfacing with upstream and downstream functions, including Development
Problem-solving skills and independent research experience demonstrated by strong publication records
Ability to work in cross-functional teams
Preferred Qualifications:
Relevant experience in biotech or pharmaceutical companies
Experience conducting biophysical characterization of proteins with MALS, DSC, HPLC, CIEF, and DLS

Supervisory Responsibilities:
None

Salary:
$65,000-$95,000

Required Education:
Masters Degree

http://www.biospace.com/jobs/job-listing/?job_id=364260
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USDA Food Composition and Method Development Laboratory: Post-doctoral Fellowship

Posted: March 6, 2017
Location: Beltsville, Maryland

A postdoctoral fellowship position is available to qualitatively and quantitatively analyze bioactive ingredients in foods and dietary supplements using LC/MS.

Qualifications:
Experience in analytical chemistry and LC/MS. Experience in metobolomic research and HRAM MS is desired, but not required. The research group is Food Composition and Method Development Laboratory, USDA, ARS, Beltsville, MD 20705. Additional information and references may be found on https://www.ars.usda.gov/northeast-area/beltsville-md/beltsville-human-nutrition-research-center/food-composition-and-methods-development-laboratory/

To Apply:
Please send a curriculum vitae, bibliography, cover letter with a brief description of candidate’s interest in the position, research experience and long term career goals, and the names of 3 references (with phone numbers) via e-mail to pei.chen@ars.usda.gov.
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Icahn School of Medicine at Mt. Sinai: Senior Associate Researcher

Posted: February 23, 2017
Location: New York, NY