Monday, April 23rd, 2018

University of Maryland Multi-Omics Seminar

April 14, 2018 by  
Filed under Meetings

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April 2018 Meeting

April 2, 2018 by  
Filed under Meetings, WBMSDG Meetings

Speaker: Melanie Downs, University of Nebraska-Lincoln

Topic: MS Analysis of Food Allergens: Just Another Proteomics Application or a Whole New Kettle of Fish?

Date: Monday, April 16, 2018

Time: 6:15 pm Dinner, 7:15 pm Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Stefani Thomas (sthoma92@jhmi.edu) before Friday, April 13th if you will be attending the dinner.

Abstract: Undeclared food allergens in packaged foods represent a significant health risk for food-allergic individuals and are the leading cause of food recalls. Food manufacturers are required to label ingredients derived from food allergens and to have controls in place to prevent allergen cross-contact. Allergen control validations and risk assessments for effective allergen management plans often require supporting analytical data. As food allergens are proteins, mass spectrometry seems like an obvious analytical tool to use for detection and quantification. The capabilities of MS instruments, combined with the established track record of protein detection and quantification in clinical systems, make quantifying proteins in foods using proteomics techniques seem like a natural fit. However, the unique challenges that come along with the analysis food proteins make the path towards validated analytical methods far from smooth. In comparison to clinical samples, food proteins are exposed to a wide array of harsh conditions during various stages of processing, which leads to a number of analytical hurdles. If these challenges can be overcome, however, MS methods have the potential to fill critical gaps in our ability to analyze food allergens and ultimately protect food-allergic consumers.…

Mass Spectrometry Seminar at DTRA

March 27, 2018 by  
Filed under Meetings

April 4, 2018 at 2 pm in CR, Fort Belvoir, VA: J. M. Wells and R. G. Cooks

Options to Join
Teleconference: 703-767-5977 @ID:5905672
In Person: please contact akbar.s.khan.civ@mail.mil for instructions and directions.

“Logical Operations in Mass Spectrometry for CW and BW Defense”
J. M. Wells, Dalton T Snyder, Lucas J Szalwinski, R. G. Cooks
FLIR Detection, Inc. and Purdue University

We show entirely new modes of operating mass spectrometers that efficiently collect information on sets of compounds characterized by particular functional groups. The capability is illustrated with examples from mixtures containing opioids and CW and BW simulants. The new modes of operation provide more information than standard MS or MS/MS scans, allowing for presumptive ID and/or field confirmation of high consequence targets, even if the exact chemical structure has been modified to defeat existing detector libraries. Furthermore, the new scans are readily implemented on small, field-portable mass spectrometers based on ion traps.

Introduction: Current trends in MS continue to move towards more complex and larger systems, emphasizing prior chromatographic separation and high mass resolution. An alternative approach is to use ambient ionization, with miniature instruments, and to quickly perform unit resolution experiments that instead rely on MS/MS for chemical specificity. Ion traps are particularly appropriate for this due to their relatively compact size. Their applicability to identifying and confirming chemical targets in the field is further enhanced by operating in new MS/MS modes based on secular frequency scanning. These modes use low amplitude swept frequencies in the orthogonal x, y plane of the ion trap, rather than high voltage RF ramps. This approach greatly simplifies ion trap electronics while being more chemically informative than standard modes of operation.…

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