Saturday, November 17th, 2018

November 2018 Meeting

November 6, 2018 by  
Filed under Meetings, WBMSDG Meetings

Speaker: Daniele Fabris, University at Albany

Topic: MS-based approaches for the elucidation of nucleic acid higher-order structure and dynamics

Date: Monday, November 19, 2018

Time: 6:15 pm Dinner and Vendor Night, 7:15 pm Presentation

Location: Shimadzu Scientific Instruments, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Yan Wang (yanwang@umd.edu) by Friday, November 16th if you will be attending the dinner.

Abstract: The discovery of ribozymes and riboswitches has keenly reasserted the critical role played by higher-order structure in determining the function of nucleic acid sequences that do not code for actual proteins. Mass spectrometry-based approaches can provide valuable information about base-pairing and longrange interactions, which define the secondary, tertiary, and quaternary structure of nucleic acids. We have been developing strategies based on high-resolution and ion mobility spectrometry (IMS) mass spectrometry to investigate the structure-function relationships in noncoding viral RNA. We have demonstrated that the concerted application of footprinting and crosslinking methods can provide valid spatial constraints for modeling operations, leading to the solution of actual 3D structures. Top-down strategies can provide direct information on the position and strength of base-pairing interactions that stabilize higher-order structure. Putative structures are corroborated by IMS determinations that reveal the global topology of target RNA. These approaches constitute a valuable alternative for the investigation of systems that, owing to their large size and flexibility, are not directly amenable to classic high-resolution techniques employed in structural biology. Their implementation has been providing new insights into the processes of genome recognition, dimerization, and packaging of HIV-1 and other retroviruses, which have the potential of leading to the development of novel therapeutic strategies.…

Agilent Symposium

October 11, 2018 by  
Filed under Meetings

October 2018 Meeting

October 4, 2018 by  
Filed under Meetings, WBMSDG Meetings

Speaker: Carsten Prasse, Johns Hopkins University

Topic: Using mass spectrometry to unravel the occurrence, fate and effects of organic contaminants in the environment

Date: Monday, October 15, 2018

Time: 6:15 pm Dinner and Vendor Night, 7:15 pm Presentation

Location: Shimadzu Scientific Instruments, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Yan Wang (yanwang@umd.edu) by Friday, October 12th if you will be attending the dinner.

Abstract: More than 80,000 chemicals are used in commercial products today and many of them eventually find their way into our environment. While modern analytical tools, such as liquid-chromatography mass spectrometry, are able to detect an increasing number of chemicals in environmental samples, little is known about the fate of these compounds in the natural and built environment. In addition, limited information is available about potential toxic effects of most chemicals.
New approaches are needed that link exposures and effects and that ultimately allow for a prioritization of chemicals that are of highest concern. The presentation will discuss how mass spectrometry-based approaches can be used for i) the detection of previously unknown chemicals, ii) the identification of the transformation products that are formed in the natural and built environment and iii) the determination of toxic effects on a molecular level. …

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