Notices
1. June 24, 2013 MSDG Meeting at Shimadzu Training Center in Columbia
Post-ASMS Poster Session and Dinner with Presentations by Travel Award Recipients
2. 2013 MSDG Young Investigator Award Recipients
June MSDG Meeting
Topic: Post-ASMS Poster Session and Dinner with Presentations by Travel Award Recipients
Date: Monday, June 24, 2013
Time: 6:00 pm Dinner and Poster viewing; 7:30 pm: Presentations by Award Recipients
Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)
Dinner and Poster: Please RSVP to Peter Nemes (Peter.Nemes@fda.hhs.gov) by June 19 if you will be attending the dinner or presenting your ASMS poster.
2013 WBMSDG Young Investigator Travel Award Recipients
Lissa C. Anderson, University of Virginia:
Advisor: Professor Donald F. Hunt. Abstract title: Covalent Labeling Strategies for the Improvement of Whole Protein and Large Peptide Sequence Determination by Electron Transfer Dissociation.
Waeowalee Choksawangkarn, University of Maryland:
Advisor: Professor Catherine Fenselau. Abstract title: Use of Iron Oxide Nanoparticle Pellicles for Enrichment of Plasma Membrane Proteins from Suspended Cells.
Hang Li, George Washington University:
Advisor: Professor Akos Vertes. Abstract title: Ambient Molecular Imaging and Quantitative Analysis by Laser Ablation Electrospray Ionization Mass Spectrometry with Ion Mobility Separation.
May Meeting
Speaker: Tom Phillips, Ph.D., Maryland Department of Agriculture, Annapolis, MD
Date: Monday, May 20, 2013
Time: 7:30 pm
Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)
Dinner: Please join the speaker and the co-chairs for dinner at the Ram’s Head Tavern at Savage Mill, 8600 Foundry Street, Savage, MD 20763 at 5:30 pm. Contact Peter Nemes (Peter.Nemes@fda.hhs.gov) to let him know you will be there for dinner.
Abstract: Since the acquisition of our first hyphenated instrument in 2004, we have had several problematic matrices. These matrices have made quantitation of known compounds and identity confirmation very difficult. Matrix-dependent signal suppression or enhancement, or matrix effects (ME), represents a major problematic area in hyphenated techniques and are dependent upon the ionization technique used. Whether electrospray ionization (ESI), atmospheric pressure ionization (API) or a combination of the two, ESCI, matrix effects occur and are difficult to resolve. ME can heavily affect the reproducibility, linearity and accuracy of a quantitative method and lead to incorrect quantitation. The exact mechanism for ME is still unknown, it is commonly assumed that the co-eluted matrix can influence signal intensity in a possible competition for available charges and for access to the droplet surface for gas-phase emission. Several case studies will be presented that show both enhancement and suppression, and what was done to reduce and in some cases alleviate the ME.
