September 2019 Meeting

Speaker: Joseph Zaia, Boston University School of Medicine

Topic: Proteomics, glycomics, and glycoproteomics of matrisome molecules

Date: Monday, September 16th, 2019

Time: 6:15 pm Dinner, 7:15 pm Presentation

Location: Shimadzu Scientific Instruments, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Meghan Burke (meghan.burke@nist.gov) by Friday, September 16th if you will be attending the dinner.

Abstract: The most straightforward applications of proteomics database searching involve intracellular proteins. While intracellular gene products number in the thousands, their well-defined post-translational modifications (PTMs) makes database searching practical. By contrast, cell surface and extracellular matrisome proteins pass through the secretory pathway where many become glycosylated, modulating their physicochemical properties, adhesive interactions, and diversifying their functions. While matrisome proteins number only a few hundred, their high degree of complex glycosylation multiplies the number of theoretical proteoforms by orders of magnitude. Given that extracellular networks that mediate cell-cell and cell-pathogen interactions in physiology depend on glycosylation, it is important to characterize the proteomes, glycomes and glycoproteomes of matrisome molecules that exist in a given biological context. In this presentation, I will summarize proteomics approaches for characterizing matrisome molecules, with an emphasis on applications to brain diseases.

Fall 2019-Spring 2020 Meeting Schedule

The schedule for Fall 2019-Spring 2020 is here!

Sept. 16, 2019 – Joseph Zaia (Boston University), Vendor Show featuring WBMSDG sponsors
Oct. 21, 2019 – Leslie Hicks (UNC-Chapel Hill, ASMS Travel Award)
Nov. 18, 2019 – Will Brinckerhoff (NASA)
Dec. 16, 2019 – Asher Newsome (Smithsonian Institution)
Jan. 13, 2020 – Allison Scott (University of Maryland-Baltimore)
Feb. 10, 2020 – Joe Cannon (Merck)
Mar. 16, 2020 – Carlos Larriba-Andaluz (Purdue, ASMS Travel Award)
Apr. 20, 2020 – Ben Neely (NIST)
May 18, 2020 – Ira Lurie (George Washington University)
June 15, 2020 – Post-ASMS Poster Night, Travel Award Presentations

June 2019 Meeting

Topic: Post-ASMS Poster Night and ASMS Travel Award Presentations

Date: Monday, June 17th, 2019

Time: 6:15 pm Dinner, 7:30 pm: Presentations

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Yan Wang (yan.wang2@nih.gov) by Friday, June 14th if you will attend dinner and/or if you will participate in the poster session.

ASMS Travel Award Recipients:

  • Shao-Yung Chen, Johns Hopkins University
  • : “High Throughput Intact Glycopeptide Enrichment for Site-specific N-linked Glycosylation Analysis Utilizing Automated Liquid Handling Systems”

  • Laith Samarah, George Washington University
  • : “A Single-Cell Look at Biological Nitrogen Fixation: Rapid Determination of Metabolite Formulas fromIsotopic Fine Structures in Heterogeneous Cell Populations”

May 2019 Meeting

Speaker: Benjamin Orsburn, Think20 Labs

Topic: Removing the Limiters – New Data Processing Methods to Realize the True Potential of Today’s LCMS Technology

Date: Monday, May 20, 2019

Time: 6:15 pm Dinner, 7:15 pm Presentation

Location: Shimadzu Scientific Instruments, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Yan Wang (yan.wang2@nih.gov) by Friday, May 17th if you will be attending the dinner.

Abstract: Classical approaches to proteomic data processing have many shortcomings in terms of the identifications of mutations, individual genetic variants and post-translational modifications. Nearly all shotgun proteomic data processing is performed by matching MS/MS spectra against small, curated canonical databases that do not reflect the individual variation of the organism or tissue being studied. Incorporation of “next generations” sequencing technology outputs and improved software and hardware solutions can allow us to now see a bigger picture of the true proteomes of our tissues than ever before. In this talk I will describe recent methods and technologies that allow us to look outside of our old boxes and see the data that we’ve been missing.

April 2019 Meeting

Speaker: Catherine Fenselau, Distinguished University Professor Emerita, University of Maryland

Topic: Biological Mass Spectrometry: Observations on its Evolution

Date: Monday, April 15, 2019

Time: 6:15 pm Dinner, 7:15 pm Presentation

Location: Shimadzu Scientific Instruments, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Yan Wang (yan.wang2@nih.gov) by Friday, April 12th if you will be attending the dinner.

Abstract: Aspirations, advances in instrumentation, successful applications and Nobel prizes will be reviewed as part of the evolution of biological mass spectrometry, with illustrations from the speaker’s laboratory.