October 2019 Meeting

Speaker: Leslie Hicks, University of North Carolina at Chapel Hill

Topic: Investigating plant-derived antimicrobial peptides using PepSAVI-MS

Date: Monday, October 21st, 2019

Time: 6:15 pm Dinner, 7:15 pm Presentation

Location: Shimadzu Scientific Instruments, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Meghan Burke (meghan.burke@nist.gov) by Friday, October 18th if you will be attending the dinner.

Abstract: As current methods for antibiotic drug discovery are being outpaced by the rise of antimicrobial resistance, new methods and innovative technologies are crucial to replenish our dwindling arsenal of antimicrobial therapeutics. While natural products are a well-studied source of biologically active small molecules, peptidyl factors contributing to their medicinal properties remain largely unexplored. To this end, we have developed the PepSAVI-MS to identify bioactive peptide targets from complex biological samples. The developed platform is highly versatile as it is adaptable to any natural product source of peptides and can test against diverse physiological targets, including bacteria, fungi, and cancer cells for which there is a developed bioassay. As such, we demonstrated extension of this pipeline to fungal and bacterially-sourced AMPs and are beginning to probe the vast array of botanical natural product sources to prioritize highly active species for downstream analysis.

Burnaby Munson Memorial at U. Delaware

Celebration of Dr. Munson’s life set Oct. 4 in Mitchell Hall

(from the UDaily)

The life of Burnaby Munson, the C. Eugene Bennett Chair Emeritus of Chemistry and former director of the University of Delaware Honors Program, will be celebrated at a special event at 4 p.m., Friday, Oct. 4, in Mitchell Hall.

Dr. Munson died on June 23. He was 86.

All members of the UD community are invited to join in remembering Dr. Munson and sharing memories and moments from his legacy.

The event will be live streamed at https://sites.udel.edu/udlive.

Afterward, a reception will be held at the Honors Program, 186 South College Ave., Newark DE.

September 2019 Meeting

Speaker: Joseph Zaia, Boston University School of Medicine

Topic: Proteomics, glycomics, and glycoproteomics of matrisome molecules

Date: Monday, September 16th, 2019

Time: 6:15 pm Dinner, 7:15 pm Presentation

Location: Shimadzu Scientific Instruments, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Meghan Burke (meghan.burke@nist.gov) by Friday, September 16th if you will be attending the dinner.

Abstract: The most straightforward applications of proteomics database searching involve intracellular proteins. While intracellular gene products number in the thousands, their well-defined post-translational modifications (PTMs) makes database searching practical. By contrast, cell surface and extracellular matrisome proteins pass through the secretory pathway where many become glycosylated, modulating their physicochemical properties, adhesive interactions, and diversifying their functions. While matrisome proteins number only a few hundred, their high degree of complex glycosylation multiplies the number of theoretical proteoforms by orders of magnitude. Given that extracellular networks that mediate cell-cell and cell-pathogen interactions in physiology depend on glycosylation, it is important to characterize the proteomes, glycomes and glycoproteomes of matrisome molecules that exist in a given biological context. In this presentation, I will summarize proteomics approaches for characterizing matrisome molecules, with an emphasis on applications to brain diseases.

Fall 2019-Spring 2020 Meeting Schedule

The schedule for Fall 2019-Spring 2020 is here!

Sept. 16, 2019 – Joseph Zaia (Boston University), Vendor Show featuring WBMSDG sponsors
Oct. 21, 2019 – Leslie Hicks (UNC-Chapel Hill, ASMS Travel Award)
Nov. 18, 2019 – Will Brinckerhoff (NASA)
Dec. 16, 2019 – Asher Newsome (Smithsonian Institution)
Jan. 13, 2020 – Allison Scott (University of Maryland-Baltimore)
Feb. 10, 2020 – Joe Cannon (Merck)
Mar. 16, 2020 – Carlos Larriba-Andaluz (Purdue, ASMS Travel Award)
Apr. 20, 2020 – Ben Neely (NIST)
May 18, 2020 – Ira Lurie (George Washington University)
June 15, 2020 – Post-ASMS Poster Night, Travel Award Presentations

June 2019 Meeting

Topic: Post-ASMS Poster Night and ASMS Travel Award Presentations

Date: Monday, June 17th, 2019

Time: 6:15 pm Dinner, 7:30 pm: Presentations

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Yan Wang (yan.wang2@nih.gov) by Friday, June 14th if you will attend dinner and/or if you will participate in the poster session.

ASMS Travel Award Recipients:

  • Shao-Yung Chen, Johns Hopkins University
  • : “High Throughput Intact Glycopeptide Enrichment for Site-specific N-linked Glycosylation Analysis Utilizing Automated Liquid Handling Systems”

  • Laith Samarah, George Washington University
  • : “A Single-Cell Look at Biological Nitrogen Fixation: Rapid Determination of Metabolite Formulas fromIsotopic Fine Structures in Heterogeneous Cell Populations”