May 2020 Virtual Meeting

Speaker: Ira Lurie, George Washington University

Topic: Is GC-MS still the gold standard for the analysis of seized drugs?

Date: Thursday, May 21st, 2020

NEW TIME: 1:00 pm Presentation

Location: Webinar – see emails on May 12 and 19 for invite link. Join the mailing list

Abstract: Gas chromatography electron impact mass spectrometry (GC-EI MS) has been considered the gold standard for the analysis of seized drugs. This technique which combines a high resolution separation step with a highly selective detection technique is well established for commonly encountered illicit drugs such as cocaine and heroin. Most recently there has been an up surge of the so called designer drugs, structural or functional analogs of controlled substances that have been synthesized to mimic the pharmacological effects of the original drug, therefore avoiding classification as illegal and/or detection in standard drug tests. The analysis of these emerging drugs is complicated using GC-EI MS by the high number of analogues present in a given class, for which there exists structurally very similar compounds, such as positional isomers and stereoisomers. Problems encountered during analysis include co-elution, poor chromatographic performance, lack of molecular or diagnostic ions, indistinguishable mass spectra, and solute thermal instability. In this seminar alternative liquid phase techniques will be presented including ultra high performance liquid chromatography (UHPLC) with time of flight (TOF) MS detection, high performance supercritical fluid chromatography (UHPSFC) with MS and UV detection, and multi-dimensional UHPLC with UV and MS detection. In regard to gas phase analysis, the use of cold EI-MS and vacuum ultraviolet (VUV) detection will be explored including the use of a tandem GC-VUV-MS instrument. Emerging drug classes investigated include synthetic cannabinoids, synthetic cathinones, fentanyl analogues and phenethylamine analogues.

Waters Webinars

Waters, a Sponsor of WBMSDG, is offering a comprehensive list of free LIVE Webinars and Ask the Expert sessions.

Topics include Empower, HPLC/UPLC, Mass Spectrometry, MassLynx, UNIFI, and due to the current circumstances of Covid 19, long term shutdown procedures for Waters LC and MS Systems. Registration for these sessions can be completed using the following link at Waters Customer Education (The Promo Code for these classes is 2020WEB and this should be entered in the purchase order field). Waters will be adding additional courses throughout the April and May so check back often!

Waters also has a number of other free online resources available including webinars, fundamentals of LC/MS, how-to-videos, information on managing data, and more. Please use the following link to learn more. Starting April 8th, please join Waters for STEM Live: The Science of What’s Possible for Kids, a new weekly series, where Waters will bring fun experiments for all ages into your home laboratories.

April 2020 Virtual Meeting

Speaker: Ben Neely, NIST

Topic: Sea lions and bats and humans, oh my! How to explore mammalian serum proteomes

Date: Monday, April 20th, 2020

NEW TIME: 1:00 pm Presentation

Location: Webinar – see email on April 16 for invite link. Join the mailing list

Abstract: Comparative biology and biomimicry are broadly focused on understanding the underlying molecular basis of phenotypes relevant to chronic human ailments. Notably, research in hibernating mammals is improving our understanding of neurodegeneration, studies of diving mammals is identifying novel mechanisms of ischemia/reperfusion injury resistance, while studying organisms that follow Peto’s paradox is advancing longevity and cancer research. In addition to biomimetics, recent events are highlighting certain mammal’s ability to serve as reservoirs of infectious disease. Systematically characterizing the diversity of all mammalian proteomes will enable unexpected discoveries, but this presents numerous technological hurdles. In this seminar I will present results, recommendations and solutions to the issues of working in species without genomes or annotations, acquiring proteomic data in a standardized fashion, comparing proteomes between species and identifying molecular trends across clades with relevant phenotypes. Using the Atlantic bottlenose dolphin and California sea lion as examples, I will demonstrate improvements in proteomic analysis using genomic sequencing and gene annotation techniques, as well as emerging proteomic techniques such as data-independent acquisition applied to undepleted human and bat serum.

CANCELLED: March 2020 Meeting

Speaker: Carlos Larriba-Andaluz, Purdue School of Engineering & Technology

Topic: Understanding Ion Mobility Separation in High-Resolution Instruments. Caveats of and deviations from the Mason-Schamp Equation for small molecules.

Look for this talk to be re-scheduled in the future!

3rd Annual North American Mass Spectrometry Summer School

June 15 – 18, Madison, WI

Join us for our third annual mass spectrometry summer school. We are proud to have assembled over a dozen world leading experts in mass spectrometry for this four-day course. Our goal is to provide our students, both from academia and industry, an engaging and inspiring program covering the latest in the application of mass spectrometry to omic analyses. Tutorial lectures range from mass analyzers to the basics of data analysis. Also planned are several hands-on workshops – aimed at both scientific and professional development. This program is made possible by generous funding from the National Science Foundation (Integrated Organismal Systems, Plant Genome Research Program, Grant No. 1546742) and the National Institutes of Health National Center for Quantitative Biology of Complex Systems (P41 GM108538). As such, there is no cost to participate.

Registration open through March 1, 2020: https://www.ncqbcs.com/resources/training/summer-school.

Tutorial Lectures:
Mass analyzers
Ionization
Tandem MS
Data acquisition
Quantification
Experimental design
Separations
PTMs
Metabolomics
Top-down/Native MS
Lipidomics

Hands-on Workshops:
Mass analyzers
Spectral interpretation
Publishing and reviewing
Science writing
Science illustrations

To view this discussion on the web visit https://groups.google.com/d/msgid/mass-spec-summer-school/af93b8ab-3103-4d5e-ac46-7751925ebaf6%40googlegroups.com.