ASMS 2020 Reboot

We hope all the WBMSDG members are having virtual fun at the ASMS 2020 Reboot! Remember, all content will be viewable until August 31. Use the hashtags #ASMS2020 and #WBMSDG on social media to highlight research from our community!

The organizers at ASMS are putting together a Zoom happy hour for the mass spec community and trainees are especially encouraged to participate and socialize! The happy hour caps at 100 participants.
Registration for US/night owls (Jun 8, 2020 05:30 PM to 09:30 PM EDT): https://us02web.zoom.us/meeting/register/tZYtcOyqqTspGtYb373cNsrtWaLHF3nUT_d_

June 2020 Meeting

Topic: Post-ASMS Virtual Poster Night and ASMS Travel Award Presentations

Date: Monday, June 22nd, 2020

Time: Poster listing online (see below); 1:00 pm Presentations (details to follow)

ASMS Travel Award Recipients:

    • Gessica Vasconcelos, George Washington University

: “Fiber-based laser ablation electrospray ionization mass spectrometry for molecular profiling and metabolite gradients in anatomical regions selected by fluorescence microscopy”

    • Kunyu Zheng, Georgetown University

: “Non-targeted detection of fluorinated compounds using dielectric barrier discharge nano-electrospray ionization”

    • Yulemni Morel, Univ. of Maryland School of Pharmacy

: “Integrating Qual/Quan Workflows for Combined Structure Characterization and Quantitation of Vinyl Ether Phosphatidylethanolamine”


WBMSDG attendees are invited to submit their posters for an online listing in lieu of an in-person poster night. Submit yours via the form below!

MP 031 Non-proximate Ambient Sampling for Solvent-free Analysis of Intact Objects; G. Asher Newsome1; Kathleen Martin2; Julia Campbell-Such3; 1Smithsonian Museum Conservation Institute, Suitland, MD; 2Smithsonian National Museum of the American Indian, Hillcrest Heights, MD; 3Smithsonian National Museum of African Art, Washington, DC

MP 206 Optimization of a targeted, multi-allergen LC-MS/MS method for the quantification of egg, milk, and peanut in food; Weili Xiong1; Christine H. Parker1; Katherine L. Fiedler1; 1U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD

MP 291 The Inelasticity of Ion-Molecule Collisions in Ion Mobility Spectrometry, Glenn Spangler, Technispan LLC

MP 355 Hepatic dyslipidemia in little brown bats (Myotis lucifugus) and big brown bats (Eptesicus fuscus) with white nose syndrome; Evan L. Pannkuk1; Nicole A. S.-Y. Dorville2; Yvoone A. Dzal2; Quinn E. Fletcher2; Kaleigh J. O. Norquay2; Craig K. R. Willis2; Albert J. Fornace Jr.1,3; Evagelia C. Laiakis1,3; 1Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC; 2Department of Biology, University of Winnipeg, Winnipeg, MB; 3Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC

TP 516 Measuring protein conformational change in living cells by quantitative, comprehensive, and ultra-sensitive protein footprinting. Jenna G. Caldwell1*, Bjorn-Erik Wulff1, Lichao Zhang2, Joshua E. Elias2, Pehr A.B. Harbury2. 1Department of Biochemistry, Stanford School of Medicine, Stanford, CA; 2Chan Zuckerberg Biohub, Stanford, CA

ThP 279 Trypsin – a Tired Workhorse? The Selectivity of Atypical Cleavages by Trypsin; Meghan Burke1; Yuxue Liang1; Stephen E. Stein1; 1National Institute of Standards and Technology, Gaithersburg, Maryland

Waters IMS webinars

Join Waters for a FREE webinar on:

The Revolutionary Cyclic IMS and an Exploration of its Capabilities

Advances in mass spectrometry (MS) made during the past century have helped empower scientists to research applications in the life, chemical and material sciences. It is the challenging problems that researchers face that underpin innovation in high performance
instrumentation.

Presentation I:
Introduction to Ion Mobility and the SELECT SERIES Cyclic IMS
Discover how revolutionary cyclic ion mobility separation is combined with modern, state‐of‐the‐art time‐of‐flight mass spectrometry to overcome traditional limitations and provide new approaches. The novel cyclic ion mobility device provides scalable, high‐resolution ion mobility separations and provides the ability to perform ion mobility/ion mobility and IMSn experiments.
presenter:
Kevin Giles
Scientific Fellow
Waters MS Research
Waters Corporation

Presentation II:
Cyclic IMS – Applications, Benefits and the Future…
Learn how the unique capabilities of Cyclic Ion Mobility Mass Spectrometry are enabling researchers to unlock new information in drug discovery, biomolecular characterization, biomarker research and many other application areas and how users are influencing further development of this system.
presenter:
Emma Marsden-Edwards
Principal Product Manager
Waters Advanced MS Technologies
Waters Corporation

Each presentation is 30 minutes, and at the end of the second presentation there will be a 30 minute Q&A session. Learn more or register

May 2020 Virtual Meeting

Speaker: Ira Lurie, George Washington University

Topic: Is GC-MS still the gold standard for the analysis of seized drugs?

Date: Thursday, May 21st, 2020

NEW TIME: 1:00 pm Presentation

Location: Webinar – see emails on May 12 and 19 for invite link. Join the mailing list

Abstract: Gas chromatography electron impact mass spectrometry (GC-EI MS) has been considered the gold standard for the analysis of seized drugs. This technique which combines a high resolution separation step with a highly selective detection technique is well established for commonly encountered illicit drugs such as cocaine and heroin. Most recently there has been an up surge of the so called designer drugs, structural or functional analogs of controlled substances that have been synthesized to mimic the pharmacological effects of the original drug, therefore avoiding classification as illegal and/or detection in standard drug tests. The analysis of these emerging drugs is complicated using GC-EI MS by the high number of analogues present in a given class, for which there exists structurally very similar compounds, such as positional isomers and stereoisomers. Problems encountered during analysis include co-elution, poor chromatographic performance, lack of molecular or diagnostic ions, indistinguishable mass spectra, and solute thermal instability. In this seminar alternative liquid phase techniques will be presented including ultra high performance liquid chromatography (UHPLC) with time of flight (TOF) MS detection, high performance supercritical fluid chromatography (UHPSFC) with MS and UV detection, and multi-dimensional UHPLC with UV and MS detection. In regard to gas phase analysis, the use of cold EI-MS and vacuum ultraviolet (VUV) detection will be explored including the use of a tandem GC-VUV-MS instrument. Emerging drug classes investigated include synthetic cannabinoids, synthetic cathinones, fentanyl analogues and phenethylamine analogues.

Waters Webinars

Waters, a Sponsor of WBMSDG, is offering a comprehensive list of free LIVE Webinars and Ask the Expert sessions.

Topics include Empower, HPLC/UPLC, Mass Spectrometry, MassLynx, UNIFI, and due to the current circumstances of Covid 19, long term shutdown procedures for Waters LC and MS Systems. Registration for these sessions can be completed using the following link at Waters Customer Education (The Promo Code for these classes is 2020WEB and this should be entered in the purchase order field). Waters will be adding additional courses throughout the April and May so check back often!

Waters also has a number of other free online resources available including webinars, fundamentals of LC/MS, how-to-videos, information on managing data, and more. Please use the following link to learn more. Starting April 8th, please join Waters for STEM Live: The Science of What’s Possible for Kids, a new weekly series, where Waters will bring fun experiments for all ages into your home laboratories.